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2017 (8)
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Article (15)

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English (15)
  • 15 documents, page 1 of 2

    APPLICATIONS OF SOME NEW TRANSMUTED CUMULATIVE DISTRIBUTION FUNCTIONS IN POPULATION DYNAMICS

    Vesselin Kyurkchiev; Anton Iliev Iliev; Nikolay Kyurkchiev (2017)
    Motivation: In literature, several transformations exists to obtain a new cumulative distribution function (cdf) using other(s) well-known cdf(s). Results: In this note we find applications of some new cumulative distribution function transformations to construct a family of sigmoidal functions based on the Verhulst logistic function. We prove estimates for the Hausdorff approximation of the shifted Heaviside step function by means of this family. Numerical examples, illustrating ou...

    BIOINFORMATICS MODEL OF THE CARAPACE SCUTE PATTERN OF THE RED-EARED SLIDER TRACHEMYS SCRIPTA ELEGANS (WIED-NEUWIED, 1839)

    Andrey Kiladze (2017)
    The scutes located on the carapace of the red-eared slider Trachemys scripta elegans (Wied-Neuwied, 1839) have been modeled. Bioinformatics modeling of carapace’s scutes were carried out by utilizing the Voronoi decomposition and Delaunay triangulation method. These two geometric techniques allow the patterns of vertebral and costal scutes to be recreated. The proposed model may have a certain value for taxonomy as well as for estimating the symmetry of the morphological structures, which is ...

    DISTANT JOINING: A SEQUENCE SAMPLING METHOD FOR COMPLEX EVOLUTIONARY HISTORIES

    Alexey Anatolievich Morozov; Yuri Pavlovich Galachyants, Dr (2017)
    Motivation: Massive parallel phylogenetic analyses allow to reconstruct phylogenetic trees for every gene in genome, typically using the set of potential homologues detected via BLAST or analogue. However, if the amount of hits is too high, the dataset should be reduced to tractable size, preferably without human intervention. Currently available methods are error-prone on at least some datasets and some of them also depend on additional data which may not be available. Results: We propos...

    TAXONDC: CALCULATING THE SIMILARITY VALUE OF THE 16S RRNA GENE SEQUENCES OF PROKARYOTES OR ITS REGIONS OF FUNGI

    Sergey Vladimirovich Tarlachkov; Irina Pavlovna Starodumova (2017)
    Summary: The TaxonDC program (Taxon Distance Calculator) performs pairwise sequence alignment followed by determining the similarity value between two or more sequences of interest. Unlike widely used programs, TaxonDC makes only pairwise alignment of input sequences that allows avoiding different similarity values depending on the sequences included in the analysis. The similarity values calculated with TaxonDC are the same compared to those calculated using popular identification oriented w...

    COMPARATIVE CONSERVATION OF MEIOTIC PROTEINS IN DIFFERENT PHYLOGENETIC LINES OF EUKARYOTES

    Grishaeva, T.M. (2018)
    Motivation: Meiosis — a two-stage process of sex cell division — is served by several hundreds of proteins. A part of them went to eukaryotes from prokaryotes, others appeared in first eukaryotes, and some proteins appeared de novo in multicellular eukaryotes. We compared the conservation of proteins involved in various processes occurring in meiosis. Results: The conservations of five meiotic enzymes (MLH1, MRE11, MSH4, BRCA1, BRCA2) and three silencing markers (histone H2AX, SUMO1, ATR) ...

    A NOVEL ROLLING BASED DNA CRYPTOGRAPHY

    Rejwana Haque; Roni Saha (2017)
    DNA Cryptography can be defined as a hiding data in terms of DNA Sequence. In this paper we propose a new DNA Encryption Technique where three different types of ordering is use to make binary data into cipher text. The main stages of this encryption technique are: Key Analysis, Data and Key Arrangement, Roll in encoding, Secondary Arrangement and Shifting. Decryption process has six main steps to obtain the original binary data from the encrypted data and key. Decryption steps are: Key Analy...

    MOLECULAR TAXONOMY AND THE EVOLUTION THEORY IN LIGHT OF EMERGING BIOINFORMATIC AND COSMOLOGICAL DATA

    Sergei Y. Shchyogolev (2016)
    A brief review is given of recent advances in the taxonomic study of organisms and current views on biological evolution and the origin of life. A discussion is presented on how the treelike and net components contribute to the topology of phylogenetic constructs, with account taken of the prevailing role of horizontal gene transfer in prokaryote evolution and life. Approaches are described to the rational selection and practical use of phylogenetic markers (including 16S rRNA gene DNA sequen...

    AN IN-SILICO PERSPECTIVE TOWARDS TARGET ABILITY OF AVAILABLE DRUGS IN INFECTIOUS DISEASE TREATMENT: A POSSIBLE STRATEGY

    Ram Rup Sarkar (2017)
    Motivation: In early stage of therapeutics, several structure and ligand-based in-silico approaches have aided the modern drug discovery and design. However, such techniques are limited by availability of resolved 3D structures of targets and ligands. At the same time the growing concern of drug resistivity not only demands for new drugs but also the judicious use of presently available drugs. In such a scenario, the utilization of the already available drugs of a target molecule over the dif...

    A TWO-STAGE APPROACH FOR COMBINING GENE EXPRESSION AND MUTATION WITH CLINICAL DATA IMPROVES SURVIVAL PREDICTION IN MYELODYSPLASTIC SYNDROMES AND OVARIAN CANCER

    Yan Li; Xinyan Zhang; Tomi Akinyemiju; Akinyemi I. Ojesina; Jeff M. Szychowski; Nianjun Liu; Bo Xu; Nengjun Yi (2016)
    Motivation: Many traditional clinical prognostic factors have been known for cancer for years, but usually provide poor survival prediction. Genomic information is more easily available now which offers opportunities to build more accurate prognostic models. The challenge is how to integrate them to improve survival prediction. The common approach of jointly analyzing all type of covariates directly in one single model may not improve the prediction due to increased model complexity and canno...

    CELNETANALYZER: HIGH-PERFORMANCE JAVA PACKAGE FOR THE TOPOLOGICAL ANALYSIS OF CELLULAR NETWORKS

    Vasily Grinev; Dmitry Kushal; Vitaly Charapovich (2017)
    Summary: A simple-to-use Java-based software package CelNetAnalyzer was developed. CelNetAnalyzer is managed through a graphical user interface and it returns a comprehensive list of the topological indices including compositional complexity, degree and neighbourhood, clustering, distance, centrality and heterogeneity indices as well as simple cycles and Shannon information entropy of undirected networks. Comparative studies have shown that due to parallelization and use of enhanced and newly...