The main institutions in the R&D system are the Research and Development Council, the Government Office for Science, Research and Innovations, the Ministry of Education, Youth and Sports, and other administrative authorities responsible for R&D in their jurisdictions, government departments with their own budgetary chapters.

The Ministry of Education, Youth and Sports is the central body of state administration, among other things, for science policy, research and development, including international cooperation in this field.

The Research, Development and Innovation Council is an expert and advisory body of the Government in the field of research, experimental development and innovation.

Czech ERA Portal is an initiative of the Ministry of Education, Youth and Sports and is operated in cooperation with the Technology Centre of the Academy of Sciences of the Czech Republic.

The Government Office for Science, Research and Innovations is responsible for the R&D Information System (Czech National CRIS – IS VaVaI 2.0).

The Czech Republic National Strategy of Open Access to Scientific Information for 2017–2020 was approved by the Government on June 14, 2017 as part of Czech Open Government Partnership activities.