LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1

Refine by

Publication Year

2013 (125104)
2014 (97529)
2015 (95593)
2016 (84732)
2012 (43385)
View more
Publication Year

2013 (125104)
2014 (97529)
2015 (95593)
2016 (84732)
2012 (43385)
2011 (27569)
2010 (16326)
2009 (10775)
2008 (7057)
2017 (4579)
2007 (3376)
2006 (1576)
2005 (825)
2004 (791)
2003 (433)
2002 (346)
1996 (244)
2001 (242)
2000 (214)
1999 (172)
1998 (161)
1984 (127)
1995 (113)
1997 (106)
1989 (83)
1993 (77)
1991 (74)
1988 (73)
1992 (55)
1994 (55)
1990 (54)
1985 (38)
1986 (36)
1987 (30)
1983 (25)
1981 (24)
1979 (23)
1978 (22)
1977 (20)
1982 (19)
1974 (17)
1976 (17)
1975 (15)
1963 (10)
1973 (10)
1980 (10)
1956 (7)
1965 (7)
1972 (7)
1 (6)
1947 (6)
1968 (6)
1971 (6)
2018 (6)
1966 (5)
1962 (4)
1967 (4)
1970 (4)
1894 (3)
1909 (3)
1953 (3)
1955 (3)
1960 (3)
1961 (3)
1969 (3)
1841 (2)
1851 (2)
1859 (2)
1887 (2)
1895 (2)
1897 (2)
1920 (2)
1930 (2)
1945 (2)
1948 (2)
1949 (2)
1959 (2)
16 (1)
1845 (1)
1846 (1)
1849 (1)
1855 (1)
1857 (1)
1861 (1)
1862 (1)
1863 (1)
1869 (1)
1884 (1)
1891 (1)
1892 (1)
1893 (1)
1902 (1)
1907 (1)
1908 (1)
1911 (1)
1913 (1)
1918 (1)
1922 (1)
1924 (1)
1925 (1)

Access Mode

not available (495216)
Open Access (26873)
Closed Access (373)
Restricted (264)
Embargo (52)

Type

Dataset (398618)
Collection (119543)
Audiovisual (3794)
Software (746)
PhysicalObject (64)
View more
Type

Dataset (398618)
Collection (119543)
Audiovisual (3794)
Software (746)
PhysicalObject (64)
Film (8)
Sound (5)

Language

Undetermined (509814)
English (12192)
German (146)
Dutch; Flemish (54)
Spanish; Castilian (36)
View more
Language

Undetermined (509814)
English (12192)
German (146)
Dutch; Flemish (54)
Spanish; Castilian (36)
Italian (31)
French (28)
Portuguese (2)
Spanish (2)
Catalan; Valencian (1)

522778 research data, page 1 of 52278

A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1

Abstract Background Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets for therapeutic drug design. Methods We transfected the parental HuH6 hepatoblastoma cell line with a doxycycline-inducible shRNA against CTNNB1 (gene coding for β-catenin) to obtain an iso...

Extended source pyramid wave-front sensor for the human eye

We describe a new wave-front sensor based on the previously proposed pyramid sensor. This new sensor uses an extended source instead of a point-like source avoiding in this manner the oscillation of the pyramid. After an introductory background the sensor functioning is described. Among other possible optical testing uses, we apply the sensor to measure the wave-front aberration of the human eye. An experimental system built to test this specific application is described. Results obtained bot...

Large-image-format computed tomography imaging spectrometer for fluorescence microscopy

Multispectral imaging has significantly enhanced the analysis of fixed specimens in pathology and cytogenetics. However, application of this technology to in vivo studies has been limited. This is due in part to the increased temporal resolution required to analyze changes in cellular function. Here we present a non-scanning instrument that simultaneously acquires full spectral information (460 nm to 740 nm) from every pixel within its 2-D field of view (200 µm×200 µm) during a single integra...

Integrating transcriptomics and metabolomics to characterise the response of Astragalus membranaceus Bge. var. mongolicus (Bge.) to progressive drought stress

Abstract Background Astragalus membranaceus Bge. var. mongolicus (Bge.) Hsiao (A. mongolicus) is an important traditional Chinese herb that is cultivated on a large scale in northwestern China. Understanding plant responses to drought has important effects on ecological environment recovery and local economic development. Here, we combined transcriptomics (Illumina Hiseq 2000) and metabolomics (1H-NMR) to investigate how the roots of two-year-old A. mongolicus responded to 14 days of progres...

A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase

Chu, Ya-Yun; Götz, Friedrich (2015)
Publisher: Universitätsbibliothek Tübingen
Embargo end date: 2015/09/18

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

Abstract Background There is lack of evidence about systemic treatment of pseudomyxoma peritonei (PMP) relapsing after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. There is also lack of biomarkers able to predict outcomes beyond known clinical and pathological prognostic features. Methods Fifteen patients with relapsed PMP and progressive disease within the last 6 months were included and received metronomic capecitabine (625 mg/mq/day b.i.d.) and bevacizumab (7.5 mg/K...

cnvScan: a CNV screening and annotation tool to improve the clinical utility of computational CNV prediction from exome sequencing data

Abstract Background With advances in next generation sequencing technology and analysis methods, single nucleotide variants (SNVs) and indels can be detected with high sensitivity and specificity in exome sequencing data. Recent studies have demonstrated the ability to detect disease-causing copy number variants (CNVs) in exome sequencing data. However, exonic CNV prediction programs have shown high false positive CNV counts, which is the major limiting factor for the applicability of these p...

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana

Abstract Background Human rotaviruses are the main cause of severe gastroenteritis in children and are responsible for over 500 000 deaths annually. There are two live rotavirus vaccines currently available, one based on human rotavirus serotype G1P[8], and the other a G1-G4 P[8] pentavalent vaccine. However, the recent emergence of the G9 and other novel rotavirus serotypes in Africa and Asia has prompted fears that current vaccines might not be fully effective against these new varieties. R...