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571651 research data, page 1 of 57166

Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry

Abstract Background There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a large cohort of children with juvenile uveitis. Methods This is a cross-sectional cohort study of patients with uveitis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRAnet) registry. Clinical information including, demographic information,...

Reduced pollinator service and elevated pollen limitation at the geographic range limit of an annual plant

Mutualisms are well known to influence individual fitness and the population dynamics of partner species, but little is known about whether they influence species distributions and the location of geographic range limits. Here, we examine the contribution of plant–pollinator interactions to the geographic range limit of the California endemic plant Clarkia xantiana ssp. xantiana. We show that pollinator availability declined from the center to the margin of the geographic range consistently a...

CONSTRAINTS ON PRIMARY PRODUCER N:P STOICHIOMETRY ALONG N:P SUPPLY RATIO GRADIENTS

A current principle of ecological stoichiometry states that the nitrogen to phosphorus ratio (N:P) of primary producers should closely match that from environmental nutrient supplies. This hypothesis was tested using data from ponds in Michigan, USA, a freshwater mesocosm experiment, a synthesis of studies from diverse systems (cultures, lakes, streams, and marine and terrestrial environments), and simple dynamic models of producer growth and nutrient content. Unlike prior laboratory studies,...

A molecular genetic toolbox for Yarrowia lipolytica

Abstract Background Yarrowia lipolytica is an ascomycete yeast used in biotechnological research for its abilities to secrete high concentrations of proteins and accumulate lipids. Genetic tools have been made in a variety of backgrounds with varying similarity to a comprehensively sequenced strain. Results We have developed a set of genetic and molecular tools in order to expand capabilities of Y. lipolytica for both biological research and industrial bioengineering applications. In this wor...

November 21, 2012

http://orcid.org/0000-0001-6684-3527 (2016)
Publisher: Arctic Data Center

Three-Dimensional Arrangement Of Human Bone Marrow Microvessels Revealed By Immunohistology In Undecalcified Sections - Final Data

Lobachev, Oleg (2016)
Publisher: Zenodo
These are the meshes used to render the videos in 10.5281/zenodo.57834 and 10.5281/zenodo.57754 The file names are: R[n]_[kind].ply where n is the ROI number, 1-4 kind is the diameter mesh or the overview mesh. The diameter meshes have additionally removed inner components and also other small non-connected components, as described in the paper.

Analysis Of Neighborhood Dynamics Of Forest Ecosystems Using Likelihood Methods And Modeling

Canham, Charles D; María Uriarte (2016)
Publisher: Figshare
Advances in computing power in the past 20 years have led to a proliferation of spatially explicit, individual-based models of population and ecosystem dynamics. In forest ecosystems, the individual-based models encapsulate an emerging theory of “neighborhood” dynamics, in which fine-scale spatial interactions regulate the demography of component tree species. The spatial distribution of component species, in turn, regulates spatial variation in a whole host of community and ecosystem propert...

Horizontal, but not vertical, biotic interactions affect fine-scale plant distribution patterns in a low-energy system

Studies of species range determinants have traditionally focused on abiotic variables (typically climatic conditions), and therefore the recent explicit consideration of biotic interactions represents an important advance in the field. While these studies clearly support the role of biotic interactions in shaping species distributions, most examine only the influence of a single species and/or a single interaction, failing to account for species being subject to multiple concurrent interactio...

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

Abstract Background DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. Results We use whole genome bisulfite sequencing, and find that differentiation of mouse colonic intestinal stem cells to intestinal epithelium is not associated with major changes in DNA methylation. However, we detect extensive dynamic epigenetic changes in intestinal stem cells and their p...