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539578 research data, page 1 of 53958

Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry

Abstract Background There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a large cohort of children with juvenile uveitis. Methods This is a cross-sectional cohort study of patients with uveitis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRAnet) registry. Clinical information including, demographic information,...

A molecular genetic toolbox for Yarrowia lipolytica

Abstract Background Yarrowia lipolytica is an ascomycete yeast used in biotechnological research for its abilities to secrete high concentrations of proteins and accumulate lipids. Genetic tools have been made in a variety of backgrounds with varying similarity to a comprehensively sequenced strain. Results We have developed a set of genetic and molecular tools in order to expand capabilities of Y. lipolytica for both biological research and industrial bioengineering applications. In this wor...

November 21, 2012

http://orcid.org/0000-0001-6684-3527 (2016)
Publisher: Arctic Data Center

Three-Dimensional Arrangement Of Human Bone Marrow Microvessels Revealed By Immunohistology In Undecalcified Sections - Final Data

Lobachev, Oleg (2016)
Publisher: Zenodo
These are the meshes used to render the videos in 10.5281/zenodo.57834 and 10.5281/zenodo.57754 The file names are: R[n]_[kind].ply where n is the ROI number, 1-4 kind is the diameter mesh or the overview mesh. The diameter meshes have additionally removed inner components and also other small non-connected components, as described in the paper.

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

Abstract Background DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. Results We use whole genome bisulfite sequencing, and find that differentiation of mouse colonic intestinal stem cells to intestinal epithelium is not associated with major changes in DNA methylation. However, we detect extensive dynamic epigenetic changes in intestinal stem cells and their p...

Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues

Abstract Introduction Pathologists currently diagnose breast lesions through histologic assessment, which requires fixation and tissue preparation. The diagnostic criteria used to classify breast lesions are qualitative and subjective, and inter-observer discordance has been shown to be a significant challenge in the diagnosis of selected breast lesions, particularly for borderline proliferative lesions. Thus, there is an opportunity to develop tools to rapidly visualize and quantitatively in...

Strange baryon production in Z hadronic decays

CERN-LEP. Delphi Collaboration. Measurement of the production cross section for the strange baryons XI-, XI(1530)0, SIGMA(1385)+ and SIGMA+- in hadronic decays of the Z0.

Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension

Using a spectral domain OCT system, equipped with a broadband Ti:sapphire laser, we imaged the human retina with 5 µm x 1.3 µm transverse and axial resolution at acquisition rate of 100 kHz. Such imaging speed significantly reduces motion artifacts. Combined with the ultra-high resolution, this allows observing microscopic retinal details with high axial definition without the help of adaptive optics. In this work we apply our system to image the parafoveal capillary network. We demonstrate h...