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20863 research data, page 1 of 2087

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states

Abstract Background Tissue infiltration by neutrophils during acute inflammatory states causes substantial tissue injury. While the magnitude of tissue neutrophil accumulation in innate immune responses is profoundly greater in males than females, fundamental aspects of the molecular mechanisms underlying these sex differences remain largely unknown. Methods We investigated sex differences in neutrophil stimulation and recruitment in ischemia/reperfusion (I/R; mesenteric or renal) or carragee...

Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus

Abstract Background Proton irradiation poses a potential hazard to astronauts during and following a mission, with post-mitotic cells at most risk because they cannot dilute resultant epigenetic changes via cell division. Persistent epigenetic changes that result from environmental exposures include gains or losses of DNA methylation of cytosine, which can impact gene expression. In the present study, we compared the long-term epigenetic effects of whole body proton irradiation in the mouse h...

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

Abstract Background The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers activation of inflammasomes, protein complexes responsible for IL-1β maturation in microglial cells. Downregulation of NALP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome has been shown to decrease amyloid load and rescue cognitive deficits in a mouse model of AD. Whereas activation of infl...

Primary and Supplementary Figures

A Murat Eren (2016)
Publisher: Figshare
Figures published in the study by Vineis et al, 2016.

Homicides in Chicago, 1965-1995

Block, Carolyn Rebecca; Block, Richard L.; Illinois Criminal Justice Information Authority (1995)
Publisher: ICPSR - Interuniversity Consortium for Political and Social Research
These datasets contain information on every homicide in the murder analysis files of the Chicago Police Department for the years 1965-1995. For the victim-level file, Part 1, data are provided on the relationship of victim to offender, whether the victim or offender had previously committed a violent or nonviolent offense, time of occurrence and place of homicide, type of weapon used, cause and motivation for the incident, whether the incident involved drugs, alcohol, gangs, child abuse, or a...

Framing overdiagnosis in breast screening: a qualitative study with Australian experts

Lisa Parker; Lucie Rychetnik; Stacy Carter (2015)
Publisher: Figshare
Abstract Background The purpose of this study was to identify how the topic of overdiagnosis in breast cancer screening is framed by experts and to clarify differences and similarities within these frames in terms of problems, causes, values and solutions. Methods We used a qualitative methodology using interviews with breast screening experts across Australia and applying framing theory to map and analyse their views about overdiagnosis. We interviewed 33 breast screening experts who influen...

The Embodiment of Success and Failure as Forward versus Backward Movements

Fetterman, Adam K. (2015)
Publisher: Universitätsbibliothek Tübingen
Embargo end date: 2015/04/14