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PARVA Promotes Metastasis by Modulating ILK Signalling Pathway in Lung Adenocarcinoma

α-parvin (PARVA) is known to be involved in the linkage of integrins, regulation of actin cytoskeleton dynamics and cell survival. However, the role that PARVA plays in cancer progression remains unclear. Here, using a lung cancer invasion cell line model and expression microarrays, we identify PARVA as a potential oncogene. The overexpression of PARVA increased cell invasion, colony-forming ability and endothelial cell tube formation. By contrast, knockdown of PARVA inhibited invasion and tu...

Chlamydia trachomatis infection load.

*The individual infection load is the geometric mean and 95% CI of the C. trachomatis infection load expressed in copies of ompA/swab, for all infected individuals in the study population.†The community load of infection is the Williams Mean for the study population (including uninfected individuals), expressed in copies of the ompA/swab.

SfswapTg/Tg, Jag1+/− mutants have enhanced phenotypes in the cochlea.

Measurements of cochlear lengths reveal that SfswapTg/Tg, Jag1+/− mutants are significantly shorter than SfswapTg/Tg or Jag1+/− mutants. Similarly, at the base and mid, SfswapTg/Tg, Jag1+/− mutants have significantly fewer outer hair cells (OHC) than SfswapTg/Tg or Jag1+/− mutants alone.

Baseline characteristics for each treatment group: (Mean +/− s.d. (% of missing observations) for continuous data or n (% of students who responded) for dichotomous data).

Baseline characteristics for each treatment group: (Mean +/− s.d. (% of missing observations) for continuous data or n (% of students who responded) for dichotomous data).

Study characteristics of atrial fibrillation patients not taking VKA.

@Some studies used more than one definition and all definitions are included.*12 studies didn't provided the number pts-year follow up.#some studies have more than one arm.

Factors Contributing to Maternal and Child Mortality Reductions in 146 Low- and Middle-Income Countries between 1990 and 2010

IntroductionFrom 1990–2010, worldwide child mortality declined by 43%, and maternal mortality declined by 40%. This paper compares two sources of progress: improvements in societal coverage of health determinants versus improvements in the impact of health determinants as a result of technical change.MethodsThis paper decomposes the progress made by 146 low- and middle-income countries (LMICs) in lowering childhood and maternal mortality into one component due to better health determinants li...