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600799 research data, page 1 of 60080

A novel system for tracking social preference dynamics in mice reveals sex- and strain-specific characteristics

Shai Netser; Shani Haskal; Hen Magalnik; Shlomo Wagner (2017)
Publisher: Figshare
Abstract Background Deciphering the biological mechanisms underlying social behavior in animal models requires standard behavioral paradigms that can be unbiasedly employed in an observer- and laboratory-independent manner. During the past decade, the three-chamber test has become such a standard paradigm used to evaluate social preference (sociability) and social novelty preference in mice. This test suffers from several caveats, including its reliance on spatial navigation skills and neglig...

Top-down control inhibits spatial self-organization of a patterned landscape

Regular, self-organized spatial patterns in primary producers have been described in a wide range of ecosystems and are predicted to affect community production and resilience. Although consumers are abundant in most systems, the effect of trophic interactions on pattern formation in primary producers remains unstudied. We studied the effects of top-down control by herbivores on a self-organized landscape of regularly spaced, diatom-covered hummocks alternating with water-filled hollows on an...

Assessment of genome annotation using gene function similarity within the gene neighborhood

Abstract Background Functional annotation of bacterial genomes is an obligatory and crucially important step of information processing from the genome sequences into cellular mechanisms. However, there is a lack of computational methods to evaluate the quality of functional assignments. Results We developed a genome-scale model that assigns Bayesian probability to each gene utilizing a known property of functional similarity between neighboring genes in bacteria. Conclusions Our model clearly...

Genetic Copy Number Variation and General Cognitive Ability

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested th...

Sampling Locations for MSAR Pathogen Source Evaluation Study.

Sampling Locations for MSAR Pathogen Source Evaluation Study.

Multiple regression analysis between interocular difference (IOD) in macular layers as dependent variable and IOD in axial length (AL) and best-corrected visual acuity (BCVA).

Adjusted R square, which indicates the strength of the model, standardised regression coefficients (beta) and p values.GCL+IPL: ganglion cell layer and inner plexiform layer complex; GCC: ganglion cell complex; INL: inner nuclear layer, OPL: outer plexiform layer; ONL: outer nuclear layer; RPE: retinal pigment epithelium.

Definition of symbols.

Definition of symbols.

Multiple regression analysis with FEV1 as dependent variable and age, sex, BMI, smoking status, TBARS, PSH and ADMA/arginine ratio as independent variables, in controls and COPD patients.

Multiple regression analysis with FEV1 as dependent variable and age, sex, BMI, smoking status, TBARS, PSH and ADMA/arginine ratio as independent variables, in controls and COPD patients.