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17122 research data, page 1 of 1713

Increased primary production shifts the structure and composition of a terrestrial arthropod community

Numerous studies have examined relationships between primary production and biodiversity at higher trophic levels. However, altered production in plant communities is often tightly linked with concomitant shifts in diversity and composition, and most studies have not disentangled the direct effects of production on consumers. Furthermore, when studies do examine the effects of plant production on animals in terrestrial systems, they are primarily confined to a subset of taxonomic or functiona...

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states

Abstract Background Tissue infiltration by neutrophils during acute inflammatory states causes substantial tissue injury. While the magnitude of tissue neutrophil accumulation in innate immune responses is profoundly greater in males than females, fundamental aspects of the molecular mechanisms underlying these sex differences remain largely unknown. Methods We investigated sex differences in neutrophil stimulation and recruitment in ischemia/reperfusion (I/R; mesenteric or renal) or carragee...

Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus

Abstract Background Proton irradiation poses a potential hazard to astronauts during and following a mission, with post-mitotic cells at most risk because they cannot dilute resultant epigenetic changes via cell division. Persistent epigenetic changes that result from environmental exposures include gains or losses of DNA methylation of cytosine, which can impact gene expression. In the present study, we compared the long-term epigenetic effects of whole body proton irradiation in the mouse h...

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

Abstract Background The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers activation of inflammasomes, protein complexes responsible for IL-1β maturation in microglial cells. Downregulation of NALP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome has been shown to decrease amyloid load and rescue cognitive deficits in a mouse model of AD. Whereas activation of infl...

Primary and Supplementary Figures

A Murat Eren (2016)
Publisher: Figshare
Figures published in the study by Vineis et al, 2016.

Framing overdiagnosis in breast screening: a qualitative study with Australian experts

Lisa Parker; Lucie Rychetnik; Stacy Carter (2015)
Publisher: Figshare
Abstract Background The purpose of this study was to identify how the topic of overdiagnosis in breast cancer screening is framed by experts and to clarify differences and similarities within these frames in terms of problems, causes, values and solutions. Methods We used a qualitative methodology using interviews with breast screening experts across Australia and applying framing theory to map and analyse their views about overdiagnosis. We interviewed 33 breast screening experts who influen...

The Embodiment of Success and Failure as Forward versus Backward Movements

Fetterman, Adam K. (2015)
Publisher: Universitätsbibliothek Tübingen
Embargo end date: 2015/04/14

Synchrony of population dynamics of two vineyard arthropods occurs at multiple spatial and temporal scales

When populations are synchronized, they rise and fall together. Analysis of population synchrony and its relationship to distance has played a major role in population ecology but has been absent from most studies of managed populations, such as agricultural arthropods. The extent to which populations at different locations are synchronized reflects the relative roles of shared environmental impacts, such as weather, and localizing processes, such as dispersal. The strength and pattern of syn...