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4879 research data, page 1 of 488

Efficient Removal of Heavy Metal Ions with Biopolymer Template Synthesized Mesoporous Titania Beads of Hundreds of Micrometers Size

Wu, Na; Wei, Huanhuan; Zhang, Lizhi (2012)
Publisher: Figshare
We demonstrated that mesoporous titania beads of uniform size (about 450 μm) and high surface area could be synthesized via an alginate biopolymer template method. These mesoporous titania beads could efficiently remove Cr­(VI), Cd­(II), Cr­(III), Cu­(II), and Co­(II) ions from simulated wastewater with a facile subsequent solid–liquid separation because of their large sizes. We chose Cr­(VI) removal as the case study and found that each gram of these titania beads could ...

Nanoscale Structure and Dynamics of ABOBEC3G Complexes with Single-Stranded DNA

Shlyakhtenko, Luda S.; Lushnikov, Alexander Y.; Miyagi, Atsushi; Li, Ming; Harris, Reuben S.; Lyubchenko, Yuri L. (2012)
Publisher: Figshare
The DNA cytosine deaminase APOBEC3G (A3G) is capable of blocking retrovirus replication by editing viral cDNA and impairing reverse transcription. However, the biophysical details of this host–pathogen interaction are unclear. We applied atomic force microscopy (AFM) and hybrid DNA substrates to investigate properties of A3G bound to single-stranded DNA (ssDNA). Hybrid DNA substrates included ssDNA with 5′ or 3′ ends attached to DNA duplexes (tail-DNA) and gap-DNA substra...

Measuring Uptake Dynamics of Multiple Identifiable Carbon Nanotube Species via High-Speed Confocal Raman Imaging of Live Cells

Kang, Jeon Woong; Nguyen, Freddy T.; Lue, Niyom; Dasari, Ramachandra R.; Heller, Daniel A. (2016)
Publisher: Figshare
Carbon nanotube uptake was measured via high-speed confocal Raman imaging in live cells. Spatial and temporal tracking of two cell-intrinsic and nine nanotube-derived Raman bands was conducted simultaneously in RAW 264.7 macrophages. Movies resolved single (n, m) species, defects, and aggregation states of nanotubes transiently as well as the cell position, denoted by lipid and protein signals. This work portends the real-time molecular imaging of live cells and tissues usin...

Visualizing Dynamics of Sub-Hepatic Distribution of Nanoparticles Using Intravital Multiphoton Fluorescence Microscopy

Cheng, Shih-Hsun; Li, Feng-Chieh; Souris, Jeffrey S.; Yang, Chung-Shi; Tseng, Fan-Gang; Lee, Hsuan-Shu; Chen, Chin-Tu; Dong, Chen-Yuan; Lo, Leu-Wei (2016)
Publisher: Figshare
Nanoparticles that do not undergo renal excretion or in vivo degradation into biocompatible debris often accumulate in the reticuloendothelial system, also know as the mononuclear phagocyte system, with undesired consequences that limit their clinical utility. In this work, we report the first application of intravital multiphoton fluorescence microscopy to dynamically track the hepatic metabolism of nanoparticles with subcellular resolution in real time. Using fluorescently labeled mesoporou...

Particle Shape Anisotropy in Pickering Emulsions: Cubes and Peanuts

W. J. de Folter, Julius; Hutter, Eline M.; I. R. Castillo, Sonja; Klop, Kira E.; Philipse, Albert P.; Kegel, Willem K. (2014)
Publisher: Figshare
We have investigated the effect of particle shape in Pickering emulsions by employing, for the first time, cubic and peanut-shaped particles. The interfacial packing and orientation of anisotropic microparticles are revealed at the single-particle level by direct microscopy observations. The uniform anisotropic hematite microparticles adsorb irreversibly at the oil–water interface in monolayers and form solid-stabilized o/w emulsions via the process of limited coalesce...

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

Howard, Brittany L.; Harvey, Katherine L.; Stewart, Rebecca J.; Azevedo, Mauro F.; Crabb, Brendan S.; Jennings, Ian G.; Sanders, Paul R.; Manallack, David T.; Thompson, Philip E.; Tonkin, Christopher J.; Gilson, Paul R. (2015)
Publisher: Figshare
Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, the causative agents of severe malaria and toxoplasmosis, respectively, undergo several critical developmental transitions during their lifecycle. Most important for human pathogenesis is the asexual cycle, in which parasites undergo rounds of host cell invasion, replication, and egress (exit), destroying host cell tissue in the process. Previous work has identified important roles for Protein ...

Spatially Controlled Surface Energy Traps on Superhydrophobic Surfaces

Milionis, Athanasios; Fragouli, Despina; Martiradonna, Luigi; Anyfantis, George C.; Cozzoli, P. Davide; Bayer, Ilker S.; Athanassiou, Athanassia (2014)
Publisher: Figshare
Water wetting and adhesion control on polymeric patterns are achieved by tuning the configuration of their surface’s structural characteristics from single to dual and triple length-scale. In particular, surfaces with combined micro-, submicrometer-,and nanoroughness are developed, using photolithographically structured SU-8 micro-pillars as substrates for the consecutive spray deposition of polytetrafluoroethylene (PTFE) submicrometer particles and hydrophobically capped...

Fluidic Timers for Time-Dependent, Point-of-Care Assays on Paper

Noh, Hyeran; Phillips, Scott T. (2010)
Publisher: Figshare
This article describes an integrated approach to tracking the end point of a time-based assay that is conducted on an analytical device made out of paper. The timing mechanism is built directly into a paper-based analytical device and does not require starting, stopping, reset buttons, batteries, or maintenance; the timer simply starts once the sample is added to the device. These “fluidic timers” are composed of paraffin wax and a signaling feature (e.g., a dye). The timing function is made ...

MARCKS-ED Peptide as a Curvature and Lipid Sensor

Morton, Leslie A.; Yang, Hengwen; Saludes, Jonel P.; Fiorini, Zeno; Beninson, Lida; Chapman, Edwin R.; Fleshner, Monika; Xue, Ding; Yin, Hang (2013)
Publisher: Figshare
Membrane curvature and lipid composition regulates important biological processes within a cell. Currently, several proteins have been reported to sense and/or induce membrane curvatures, e.g., Synaptotagmin-1 and Amphiphysin. However, the large protein scaffold of these curvature sensors limits their applications in complex biological systems. Our interest focuses on identifying and designing peptides that can sense membrane curvature based on established elements observ...

Analyzing the Molecular Basis of Enzyme Stability in Ethanol/Water Mixtures Using Molecular Dynamics Simulations

Lousa, Diana; Baptista, António M.; Soares, Cláudio M. (2016)
Publisher: Figshare
One of the drawbacks of nonaqueous enzymology is the fact that enzymes tend to be less stable in organic solvents than in water. There are, however, some enzymes that display very high stabilities in nonaqueous media. In order to take full advantage of the use of nonaqueous solvents in enzyme catalysis, it is essential to elucidate the molecular basis of enzyme stability in these media. Toward this end, we performed μs-long molecular dynamics simulations using two homo...