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4608 research data, page 1 of 461

Quantum Dot Targeting with Lipoic Acid Ligase and HaloTag for Single-Molecule Imaging on Living Cells

We present a methodology for targeting quantum dots to specific proteins on living cells in two steps. In the first step, Escherichia coli lipoic acid ligase (LplA) site-specifically attaches 10-bromodecanoic acid onto a 13 amino acid recognition sequence that is genetically fused to a protein of interest. In the second step, quantum dots derivatized with HaloTag, a modified haloalkane dehalogenase, react with the ligated bromodecanoic acid to form a covalent adduct. We found this targeting m...

Directed Organization of DNA Filaments in a Soft Matter Template

We have developed a noninvasive, all-optical, holographic technique for permanently aligning liquid crystalline DNA filaments in a microperiodic template realized in soft-composite (polymeric) materials. By combining optical intensity holography with a selective microfluidic etching process, a channelled microstructure has been realized which enables self-assembly of DNA. The striking chemicophysical properties of the structure immobilize the DNA filaments within the micr...

Directed Self-Assembly of Surfactants in Carbon Nanotube Materials

Angelikopoulos, Panagiotis; Bock, Henry (2008)
Publisher: Figshare
The self-assembly of surfactant molecules on crossing carbon nanotubes has been investigated using a bead-spring model and implicit solvent dissipative particle dynamics simulations. Adsorption is directed to the nanotube crossing by its higher hydrophobic potential which is due to the presence of two surfaces. As a consequence of the tendency of surfactant molecules to self-assemble into micelles, the adsorbed molecules form a “central aggregate” at the crossing, thus, confining the molecule...

Human Metabolic, Mineral, and Microbiota Fluctuations Across Daily Nutritional Intake Visualized by a Data-Driven Approach

Misawa, Takuma; Date, Yasuhiro; Kikuchi, Jun (2015)
Publisher: Figshare
Daily intake information is important for an understanding of the metabolic fluctuation of humans exposed to environmental stimuli. However, little investigation has been performed on the variations in dietary intake as an input and the relationship with human fecal, urinary, and salivary metabolic fluctuations as output information triggered by daily dietary intake. In the present study, we describe a data-driven approach for visualizing the daily intake information o...

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Oligonucleotides are promising drug candidates due to the exceptionally high specificity they exhibit toward their target DNA and RNA sequences. However, their poor pharmacokinetic and pharmacodynamic properties, in conjunction with problems associated with their internalization by cells, necessitates their delivery through specialized carrier systems for efficient therapy. Here, we investigate the effects of carrier morphology on the cellular internalization mechanisms o...

Supplementary Movie 3 - 3D reconstruction of the dendritic segment displayed in Movie 1.

3D reconstruction of the dendritic segment displayed in Supplementary Movie 1. The dendritic shaft is shown in dark green, the dendritic spines in pale green and their synapses in red. -- This data is part of the peer reviewed publication: FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons. Front. Neuroanat. | doi: 10.3389/fnana2015.00060

FeP Nanoparticles Film Grown on Carbon Cloth: An Ultrahighly Active 3D Hydrogen Evolution Cathode in Both Acidic and Neutral Solutions

In this Letter, we demonstrate the direct growth of FeP nanoparticles film on carbon cloth (FeP/CC) through low-temperature phosphidation of its Fe3O4/CC precursor. Remarkably, when used as an integrated 3D hydrogen evolution cathode, this FeP/CC electrode exhibits ultrahigh catalytic activity comparable to commercial Pt/C and good stability in acidic media. This electrode also performs well in neutral solutions. This work offers us the most cost-effective and active 3D c...

Highly Efficient Temperature-Induced Visible Light Photocatalytic Hydrogen Production from Water

Han, Bing; Hu, Yun Hang (2015)
Publisher: Figshare
Intensive effort has led to numerous breakthroughs for photoprocesses. So far, however, energy conversion efficiency for the visible-light photocatalytic splitting of water is still very low. In this paper, we demonstrate (1) surface-diffuse-reflected-light can be 2 orders of magnitude more efficient than incident light for photocatalysis, (2) the inefficiency of absorbed visible light for the photocatalytic H2 production from water with a sacrificial agent is due to i...

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with advanced intermediates, two synthetic steps away from the final active pharmaceutical ingredient, and ended with finished tablets. The entire process was run on several occasions, with the data presented herein corresponding to a 240 h run at a nominal throughpu...

Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1

Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration. PTRF/cavin-1 is a cytoplasmic protein now established to be also necessary for caveola formation. Here we tested the effect of PTRF expression on cell migration. Using fluorescence imaging, quantitative proteomics, and cell migration assays we show that PTRF/cavin-1 modulates cellular polarization, and the subcellular lo...