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4355 research data, page 1 of 436

Integral p-adic Hodge theory

Bhatt, Bhargav (2015)
Publisher: Institut des Hautes Études Scientifiques (IHÉS)
I will describe joint work with M. Morrow and P. Scholze on the construction of a new integral cohomology theory for smooth projective schemes over the ring of integers of a p-adic field. The new theory realizes de Rham cohomology as a specialization of etale cohomology (integrally), and thus yields consequences about torsion by semicontinuity.

Supplementary_Movie_5_17_30_55_lr.mp4

Otto Lappi; Paavo Rinkkala; Jami Pekkanen (2017)
Publisher: Figshare
Annotated data of the gaze behavior of one highly experienced driver (a driving school instructor).

Enhanced Real-Time Monitoring of Adeno-Associated Virus Trafficking by Virus–Quantum Dot Conjugates

The unique spectral properties of semiconductor quantum dots (QDs) enable long-term live-cell imaging and ultrasensitive detection of viral particles, which in turn can potentially provide a practical means for detailed analysis of the underlying molecular mechanisms of virus entry. In this study, we report a general method of labeling adeno-associated virus serotype 2 (AAV2) with QDs for enhanced visualization of the intracellular behavior of viruses in living target cells. It was found that...

Use of Folate-Conjugated Imaging Agents To Target Alternatively Activated Macrophages in a Murine Model of Asthma

Pro-inflammatory macrophages play a prominent role in such autoimmune diseases as rheumatoid arthritis, Crohn’s disease, psoriasis, sarcoidosis, and atherosclerosis. Because pro-inflammatory macrophages have also been shown to overexpress a receptor for the vitamin folic acid (i.e., folate receptor beta; FR-β), folate-linked drugs have been explored for use in imaging and treatment of these same diseases. To determine whether allergic inflammatory disorders might be si...

Self-Assessing Photoluminescent Polyurethanes

Crenshaw, Brent R.; WEDER, Christoph (2006)
Publisher: Figshare
Due to excimer formation upon self-assembly, the photoluminescence (PL) spectra of isolated and aggregated cyano-substituted oligo(p-phenylene vinylene) (cyano-OPV) molecules can be very different. With the objective to create self-assessing elastomers, which reversibly change their PL color as a function of applied strain, cyano-OPVs were used here as built-in deformation sensors in thermoplastic polyurethanes (TPUs). Binary blends of a commercial TPU and 0.05−0.4% w/w of various...

Graphene Growth on Pt(111) by Ethylene Chemical Vapor Deposition at Surface Temperatures near 1000 K

The nucleation and growth of graphene islands on a Pt(111) surface were examined at temperatures near 1000 K. Graphene was grown by chemical vapor deposition of ethylene, and a low-energy electron microscope (LEEM) was used to image the growing graphene islands with resolution of 10 nm and to perform spatially localized electron diffraction. It is shown that graphene grows bidirectionally over the step edges of Pt, and its formation can induce substantial changes in the p...

Remote Control of Lipophilic Nucleic Acids Domain Partitioning by DNA Hybridization and Enzymatic Cleavage

Lateral partitioning of lipid-modified molecules between liquid-disordered (ld) and liquid-ordered (lo) domains depends on the type of lipid modification, presence of a spacer, membrane composition, and temperature. Here, we show that the lo domain partitioning of the palmitoylated peptide nucleic acid (PNA) can be influenced by formation of a four-component complex with the ld domain partitioning tocopherol-modified DNA: the PNA–DNA complex partitioned into the ld domain...

Visualization of Long Human Telomere Mimics by Single-Molecule Fluorescence Imaging

Study of long single-stranded telomeric DNA is important for a variety of basic science and biotechnological applications, yet few methods exist for synthesis and visualization of single copies of this DNA in solution at biologically relevant length scales necessary for assessment of heterogeneity in its structure and behavior. We have synthesized kilobase-long single-stranded human telomere mimics in situ by rolling circle replication (RCR) on a microscope coverslip surface and visualized in...

Versatile Wedge-Based System for the Construction of Unidirectional Collagen Scaffolds by Directional Freezing: Practical and Theoretical Considerations

Aligned unidirectional collagen scaffolds may aid regeneration of those tissues where alignment of cells and extracellular matrix is essential, as for instance in cartilage, nerve bundles, and skeletal muscle. Pores can be introduced by ice crystal formation followed by freeze-drying, the pore architecture reflecting the ice crystal morphology. In this study we developed a wedge-based system allowing the production of a wide range of collagen scaffolds with unidirectional...

Direct Observation of Nucleation and Growth in Amyloid Self-Assembly

Liang, Yan; Lynn, David G.; Berland, Keith M. (2010)
Publisher: Figshare
Direct Observation of Nucleation and Growth in Amyloid Self-Assembly