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141329 research data, page 1 of 14133

Hope for Restoration of Dead Valuable Bulls through Cloning Using Donor Somatic Cells Isolated from Cryopreserved Semen

L. Selokar, Naresh; Saini, Monika; Palta, Prabhat; S. Chauhan, Manmohan; Manik, Radheysham; K. Singla, Suresh (2014)
Publisher: Figshare
Somatic cells were isolated from cryopreserved semen of 4 buffalo bulls, 3 of which had died over 10 years earlier, and were established in culture. The cells expressed cytokeratin-18, keratin and vimentin indicating that they were of epithelial origin. The cells were used as nuclear donors for hand-made cloning for producing buffalo embryos. The blastocyst rate and quality, as indicated by apoptotic index, were comparable among embryos produced using cells obtained from fresh or frozen-thawe...

Hospital Stay as a Proxy Indicator for Severe Injury in Earthquakes: A Retrospective Analysis

Zhao, Lu-Ping; Gerdin, Martin; Westman, Lina; Manuel Rodriguez-Llanes, Jose; Wu, Qi; van den Oever, Barbara; Pan, Liang; Albela, Manuel; Chen, Gao; Zhang, De-Sheng; Guha-Sapir, Debarati; von Schreeb, Johan (2013)
Publisher: Figshare
IntroductionEarthquakes are the most violent type of natural disasters and injuries are the dominant medical problem in the early phases after earthquakes. However, likely because of poor data availability, high-quality research on injuries after earthquakes is lacking. Length of hospital stay (LOS) has been validated as a proxy indicator for injury severity in high-income settings and could potentially be used in retrospective research of injuries after earthquakes. In this study, we assesse...

IL-13-mediates attenuation of LPS-induced BPIFA1 expression.

Tsou, Yung-An; Lin, Chia-Der; Chen, Hui-Chen; Hsu, Hui-Ying; Wu, Lii-Tzu; Chiang-Ni, Chuan; Chen, Chih-Jung; Wu, Tsu-Fang; Kao, Min-Chuan; Chen, Yu-An; Peng, Ming-Te; Tsai, Ming-Hsui; Chen, Chuan-Mu; Lai, Chih-Ho (2015)
Publisher: Figshare
RPMI-2650 cells, either treated or untreated with IL-13 (10 ng/ml) for 48 h, were incubated with or without LPS (10 μg/ml) for further 2 h. Cell lysates were prepared to analyze the protein expression levels by using western blot. β-actin was used as the loading control. The western blots were carried out independently in triplicate and results were representative of one of three independent experiments. The expression level of each protein was quantified by signal intensity and was indicated...

Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes

Pires, Vanessa Borges; Simões, Ricardo; Mamchaoui, Kamel; Carvalho, Célia; Carmo-Fonseca, Maria (2017)
Publisher: Figshare
Splice-switching antisense oligonucleotides (SSOs) offer great potential for RNA-targeting therapies, and two SSO drugs have been recently approved for treating Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA). Despite promising results, new developments are still needed for more efficient chemistries and delivery systems. Locked nucleic acid (LNA) is a chemically modified nucleic acid that presents several attractive properties, such as high melting temperature when bound ...

Role of Type I Interferon Receptor Signaling on NK Cell Development and Functions

Guan, Jean; M. Shahjahan Miah, S.; S. Wilson, Zachary; K. Erick, Timothy; Banh, Cindy; Brossay, Laurent (2014)
Publisher: Figshare
Type I interferons (IFN) are unique cytokines transcribed from intronless genes. They have been extensively studied because of their anti-viral functions. The anti-viral effects of type I IFN are mediated in part by natural killer (NK) cells. However, the exact contribution of type I IFN on NK cell development, maturation and activation has been somewhat difficult to assess. In this study, we used a variety of approaches to define the consequences of the lack of type I interferon receptor (IF...

Implementation and Evaluation of a Fully Automated Multiplex Real-Time PCR Assay on the BD Max Platform to Detect and Differentiate Herpesviridae from Cerebrospinal Fluids

Köller, Thomas; Kurze, Daniel; Lange, Mirjam; Scherdin, Martin; Podbielski, Andreas; Warnke, Philipp (2016)
Publisher: Figshare
A fully automated multiplex real-time PCR assay—including a sample process control and a plasmid based positive control—for the detection and differentiation of herpes simplex virus 1 (HSV1), herpes simplex virus 2 (HSV2) and varicella-zoster virus (VZV) from cerebrospinal fluids (CSF) was developed on the BD Max platform. Performance was compared to an established accredited multiplex real time PCR protocol utilizing the easyMAG and the LightCycler 480/II, both very common devices in viral m...

Integron Gene Cassettes: A Repository of Novel Protein Folds with Distinct Interaction Sites

Sureshan, Visaahini; N. Deshpande, Chandrika; Boucher, Yan; E. Koenig, Jeremy; W. Stokes, H.; J. Harrop, Stephen; M. G. Curmi, Paul; Mabbutt, Bridget C. (2013)
Publisher: Figshare
Mobile gene cassettes captured within integron arrays encompass a vast and diverse pool of genetic novelty. In most cases, functional annotation of gene cassettes directly recovered by cassette-PCR is obscured by their characteristically high sequence novelty. This inhibits identification of those specific functions or biological features that might constitute preferential factors for lateral gene transfer via the integron system. A structural genomics approach incorporating x-ray crystallogr...

Cynoglossus semilaevis ISG15: A Secreted Cytokine-Like Protein That Stimulates Antiviral Immune Response in a LRGG Motif-Dependent Manner

Wang, Wei; Zhang, Min; Xiao, Zhi-zhong; Sun, Li (2012)
Publisher: Figshare
ISG15 is an ubiquitin-like protein that is induced rapidly by interferon stimulation. Like ubiquitin, ISG15 forms covalent conjugates with its target proteins in a process called ISGylation, which in mammals is known to play a role in antiviral immunity. In contrast to mammalian ISG15, the function of teleost ISG15 is unclear. In this study, we identified and analyzed the function of an ISG15 homologue, CsISG15, from tongue sole (Cynoglossus semilaevis). CsISG15 is composed of 162 residues an...

Transmission Electron Micrograph of transfected HL-1 cells labeled for TMEM43 with immunogold.

Siragam, Vinayakumar; Cui, Xuezhi; Masse, Stephane; Ackerley, Cameron; Aafaqi, Shabana; Strandberg, Linn; Tropak, Michael; D. Fridman, Michael; Nanthakumar, Kumaraswamy; Liu, Jun; Sun, Yu; Su, Bin; Wang, Caroline; Liu, Xiaoru; Yan, Yuqing;... (2014)
Publisher: Figshare
A and B. Single immunogold labeling experiments used 15 nm gold particles to label GFP. A. Immunogold-labeled TMEM43-WT cells. The label (large dot) is associated with the endoplasmic reticulum (arrows), nuclear envelope, and the nucleus (N). B. Immunogold-labeled TMEM43-S358L cells. Immunogold particles (large dot) are confined to bundles of cytoplasmic microfilaments (arrows) and what vacuolated endosomal structures (asterisk). The endoplasmic reticulum or nuclear envelope did not show TMEM...

A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses

W. Hill, Emmeline; Gu, Jingjing; S. Eivers, Suzanne; G. Fonseca, Rita; A. McGivney, Beatrice; Govindarajan, Preethi; Orr, Nick; M. Katz, Lisa; MacHugh, David (2010)
Publisher: Figshare
Variants of the MSTN gene encoding myostatin are associated with muscle hypertrophy phenotypes in a range of mammalian species, most notably cattle, dogs, mice, and humans. Using a sample of registered Thoroughbred horses (n = 148), we have identified a novel MSTN sequence polymorphism that is strongly associated (g.66493737C>T, P = 4.85×10−8) with best race distance among elite racehorses (n = 79). This observation was independently validated (P = 1.91×10−6) in a resampled group of Thoroughb...