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149922 research data, page 1 of 14993

FANTOM5 CAGE profiles of human and mouse samples

Hans Clevers; Albert Edge; Marc van de Wetering; Michael Detmar; Haruhiko Koseki; Matthias Edinger; Karl Ekwall; David A Hume; Richard A Axton; Mitsuko Hara; Toshio Kitamura; Yuki Hasegawa; Naoko Takahashi; Piero Carninci; Ernst Jurgen Wolvetang;... (2017)
Publisher: Figshare
In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analys...

Requirement for CRIF1 in RNA interference and Dicer-2 stability

Su Jun Lim; Anthony Scott; Xiao-Peng Xiong; Shabnam Vahidpour; Willis X. Li; John Karijolich; Dongdong Guo; Shanshan Pei; Yi-Tao Yu; Rui Zhou; Willis X Li (2015)
Publisher: Figshare

Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta

Wen Du; Ying Chi; Zhou Yang; Zong Li; Jun Cui; Bao Song; Xue Li; Shao Yang; Zhi Han; Zhong Han (2016)
Publisher: Figshare
Abstract Background Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular diseases. Because of the invasive method, limited resources, and aging problems of adult tissue-derived MSCs, more perinatal tissue-derived MSCs have been isolated and studied as promising substitutable MSCs for cell transplantation. However, fewer studies have comparatively studied the angiogenic efficacy of MSCs derived from ...

Prevalence and determinants of use of complementary and alternative medicine by hypertensive patients attending primary health care facilities in Kinshasa, Democratic Republic of the Congo: a cross-sectional study

Aimée Lulebo; Mala Mapatano; Paulin Mutombo; Eric Mafuta; Gédéon Samba; Yves Coppieters (2017)
Publisher: Figshare
Abstract Background In the Democratic Republic of the Congo the control of hypertension is poor, characterized by an increasing number of reported cases of hypertension related complications. Poor control of hypertension is associated with non-adherence to antihypertensive medication. It is well established that the use of complementary and alternative medicine is one of the main factors of non-adherence to antihypertensive medication. The aim of this study is to determine the prevalence and ...

Spatial variability of biotic and abiotic tree establishment constraints across a treeline ecotone in the Alaska Range

Kirk M. Stueve; Rachel E. Isaacs; Lucy E. Tyrrell; Roseann V. Densmore (2016)
Publisher: Figshare
Throughout interior Alaska (USA), a gradual warming trend in mean monthly temperatures occurred over the last few decades (∼2–4°C). The accompanying increases in woody vegetation at many alpine treeline (hereafter treeline) locations provided an opportunity to examine how biotic and abiotic local site conditions interact to control tree establishment patterns during warming. We devised a landscape ecological approach to investigate these relationships at an undisturbed treeline in the Alaska ...

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection

Steven Kho; Jutta Marfurt; Irene Handayuni; Zuleima Pava; Rintis Noviyanti; Andreas Kusuma; Kim Piera; Faustina Burdam; Enny Kenangalem; Daniel Lampah; Christian Engwerda; Jeanne Poespoprodjo; Ric Price; Nicholas Anstey; Gabriela Minigo;... (2016)
Publisher: Figshare
Abstract Background Plasmodium falciparum and Plasmodium vivax infections compromise dendritic cell (DC) function and expand regulatory T (Treg) cells in both clinical disease (malaria) and experimental human sub-microscopic infection. Conversely, in asymptomatic microscopy-positive (patent) P. falciparum or P. vivax infection in endemic areas, blood DC increase or retain HLA-DR expression and Treg cells exhibit reduced activation, suggesting that DC and Treg cells contribute to the control o...

BioWardrobe: an integrated platform for analysis of epigenomics and transcriptomics data

Andrey Kartashov; Artem Barski (2015)
Publisher: Figshare
Abstract High-throughput sequencing has revolutionized biology by enhancing our ability to perform genome-wide studies. However, due to lack of bioinformatics expertise, modern technologies are still beyond the capabilities of many laboratories. Herein, we present the BioWardrobe platform, which allows users to store, visualize and analyze epigenomics and transcriptomics data using a biologist-friendly web interface, without the need for programming expertise. Predefined pipelines allow users...

Mode transformation using graded photonic crystals with axial asymmetry

M. Turduev; B. B. Oner; I. H. Giden; H. Kurt (2013)
Publisher: Figshare
We propose a mode conversion method that enables transformation of the propagating mode from fundamental to higher-order modes by utilizing asymmetric graded index (A-GRIN) structures. Refractive index variations of two different asymmetric gradient profiles, i.e., exponential and Luneburg lens profiles, have been approximated by two-dimensional photonic crystals (PCs). The basic structure is composed of constant radii with different lattice sizes. The designed GRIN mode converters provide re...

Lung cancer risk among workers in the construction industry: results from two case–control studies in Montreal

Aude Lacourt; Javier Pintos; Jérôme Lavoué; Lesley Richardson; Jack Siemiatycki (2015)
Publisher: Figshare
Abstract Background Given the large number of workers in the construction industry, it is important to derive accurate and valid estimates of cancer risk, and in particular lung cancer risk. In most previous studies, risks among construction workers were compared with general populations including blue and white collar workers. The main objectives of this study were to assess whether construction workers experience excess lung cancer risk, and whether exposure to selected construction industr...

Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling

Eline Korenromp; Guy Mahiané; Matthew Hamilton; Carel Pretorius; Richard Cibulskis; Jeremy Lauer; Thomas Smith; Olivier Briët (2016)
Publisher: Figshare
Abstract Background Scale-up of malaria prevention and treatment needs to continue to further important gains made in the past decade, but national strategies and budget allocations are not always evidence-based. Statistical models were developed summarizing dynamically simulated relations between increases in coverage and intervention impact, to inform a malaria module in the Spectrum health programme planning tool. Methods The dynamic Plasmodium falciparum transmission model OpenMalaria was...