LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1

Search filters

Refine by

Access Mode

Type

Dataset (861)
Collection (691)
Audiovisual (111)
PhysicalObject (6)
Film (1)

Language

Undetermined (1366)
English (298)
German (6)
1670 research data, page 1 of 167

Food-Web Models Predict Species Abundances in Response to Habitat Change

J Gotelli, Nicholas; M Ellison, Aaron (2006)
Publisher: Figshare
Plant and animal population sizes inevitably change following habitat loss, but the mechanisms underlying these changes are poorly understood. We experimentally altered habitat volume and eliminated top trophic levels of the food web of invertebrates that inhabit rain-filled leaves of the carnivorous pitcher plant Sarracenia purpurea. Path models that incorporated food-web structure better predicted population sizes of food-web constituents than did simple keystone species models, models that...

Staphylococcus aureus Redirects Central Metabolism to Increase Iron Availability

B Friedman, David; L Stauff, Devin; Pishchany, Gleb; W Whitwell, Corbin; J Torres, Victor; P Skaar, Eric (2006)
Publisher: Figshare
Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host. However, the regulatory impact of host iron sources on S. aureus gene expression remains unknown. In this study, we combine multivariable difference gel electrophoresis and mass spectrometry with multivariate statistical analyses to systematically cluster cellular protein response across distinct iron-exposure conditions. Quadruplicate samples were simultaneously analyzed for alterations in protein ...

Rapid Validation of Protein Identifications with the Borderline Statistical Confidence via De Novo Sequencing and MS BLAST Searches

Wielsch, Natalie; Thomas, Henrik; Surendranath, Vineeth; Waridel, Patrice; Frank, Ari; Pevzner, Pavel; Shevchenko, Andrej (2006)
Publisher: Figshare
Protein identifications with the borderline statistical confidence are typically produced by matching a few marginal quality MS/MS spectra to database peptide sequences and represent a significant bottleneck in the reliable and reproducible characterization of proteomes. Here, we present a method for rapid validation of borderline hits that circumvents the need in, often biased, manual inspection of raw MS/MS spectra. The approach takes advantage of the independent interpretation ...

Schistosoma mansoni TGF-β Receptor II: Role in Host Ligand-Induced Regulation of a Schistosome Target Gene

Osman, Ahmed; G Niles, Edward; Verjovski-Almeida, Sergio; T LoVerde, Philip (2006)
Publisher: Figshare
Members of transforming growth factor-beta (TGF-β) superfamily play pivotal roles in development in multicellular organisms. We report the functional characterization of the Schistosoma mansoni type II receptor (SmTβRII). Mining of the S. mansoni expressed sequence tag (EST) database identified an EST clone that shows homology to the kinase domain of type II receptors from different species. The amplified EST sequence was used as a probe to isolate a cDNA clone spanning the entire coding regi...

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

J Lelliott, Christopher; Medina-Gomez, Gema; Petrovic, Natasa; Kis, Adrienn; M Feldmann, Helena; Bjursell, Mikael; Parker, Nadeene; Curtis, Keira; Campbell, Mark; Hu, Ping; Zhang, Dongfang; E Litwin, Sheldon; G Zaha, Vlad; T Fountain, Kimberly; Boudina, Sihem;... (2006)
Publisher: Figshare
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) has been implicated in important metabolic processes. A mouse lacking PGC-1β (PGC1βKO) was generated and phenotyped using physiological, molecular, and bioinformatic approaches. PGC1βKO mice are generally viable and metabolically healthy. Using systems biology, we identified a general defect in the expression of genes involved in mitochondrial function and, specifically, the electron trans...

An Ethnographic Study of the Social Context of Migrant Health in the United States

M Holmes, Seth (2006)
Publisher: Figshare
BackgroundMigrant workers in the United States have extremely poor health. This paper aims to identify ways in which the social context of migrant farm workers affects their health and health care. Methods and FindingsThis qualitative study employs participant observation and interviews on farms and in clinics throughout 15 months of migration with a group of indigenous Triqui Mexicans in the western US and Mexico. Study participants include more than 130 farm workers and 30 clinicians. Data ...

Sequence-Specific Recognition and Cooperative Dimerization of N-Terminal Aromatic Peptides in Aqueous Solution by a Synthetic Host

Heitmann, Lisa M.; Taylor, Alexander B.; Hart, P. John; Urbach, Adam R. (2006)
Publisher: Figshare
This article describes the selective recognition and noncovalent dimerization of N-terminal aromatic peptides in aqueous solution by the synthetic host compound, cucurbit[8]uril (Q8). Q8 is known to bind two aromatic guests simultaneously and, in the presence of methyl viologen, to recognize N-terminal tryptophan over internal and C-terminal sequence isomers. Here, the binding of Q8 to aromatic peptides in the absence of methyl viologen was studied by isothermal titration calorime...

Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

Lehrmann, Elin; Colantuoni, Carlo; Deep-Soboslay, Amy; Becker, Kevin G.; Lowe, Ross; Huestis, Marilyn A.; M. Hyde, Thomas; E. Kleinman, Joel; J. Freed, William (2006)
Publisher: Figshare
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine if different drugs of abuse effect changes in gene expression that converge in common molecular pathways. Microarray analysis was employed to assay brain gene expression in postmortem anterior prefrontal cortex (aPFC) from 42 human cocaine, can...

Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method

Meier-Schellersheim, Martin; Xu, Xuehua; Angermann, Bastian; J Kunkel, Eric; Jin, Tian; N Germain, Ronald (2006)
Publisher: Figshare
The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential activation/deactivation of membrane-bound and cytosolic components. As such, it provides particularly interesting challenges for a combined computational and experimental analysis. We developed a novel detailed molecular signaling model that, when used to simulate the response to the attractant cyclic adenos...

Rational Design and Synthesis of Porous Organic−Inorganic Hybrid Frameworks Constructed by 1,3,5-Benzenetriphosphonic Acid and Pyridine Synthons

Kong, Deyuan; Zoñ, Jerzy; McBee, Jennifer; Clearfield, Abraham (2006)
Publisher: Figshare
1,3,5-Benzenetriphosphonic acid, H6BTP, 1,3,5-[(HO)2OP]3C6H3, was reacted hydrothermally with copper salts in the absence and presence of 4,4‘-bipyridine (bpy) and 4,4‘-trimethlyenedipyridine (tbpy) in a 1:1 molar ratio leading to three new organic−inorganic hybrid frameworks. Compound 1, {Cu6[C6H3(PO3)3]2(H2O)8}·5.5H2O, has three different copper ions that are interconnected by the highly charged [1,3,5-(PO3)3C6H3]6- anionic moieties. These moieties self-assemble through tetra-co...