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1620 research data, page 1 of 162

Ptychopteridae — a family of flies (Diptera) new to the Neotropical Region and description of a new species

Graham E Rotheray (2006)
Publisher: Plazi.org taxonomic treatments database
This dataset contains the digitized treatments in Plazi based on the original journal article Hancock, E. Geoffrey, Marcos-Garcia, M-Angeles, Rotheray, Graham E. (2006): Ptychopteridae — a family of flies (Diptera) new to the Neotropical Region and description of a new species. Zootaxa 1351: 61-68, DOI: 10.5281/zenodo.174523

Screening for New Antidepressant Leads of Multiple Activities by Support Vector Machines

Lepp, Zsolt; Kinoshita, Takashi; Chuman, Hiroshi (2006)
Publisher: Figshare
Virtual screening was carried out against 21 biological targets related to depression by support vector machine classification using the same atom-type descriptors. The models were effective as 0.2−0.8 of theoretical enrichments of the external test data sets could be achieved, depending on the target. The set of predicted active molecules had large diversity and contained examples with high dissimilarity to the compounds of training sets. Filtering the database of known antidepre...

A description of a new species of Diasemopsis (Diptera, Diopsidae) from the Comoro Islands with morphological, molecular and allometric data

Marion Kotrba (2006)
Publisher: Plazi.org taxonomic treatments database
This dataset contains the digitized treatments in Plazi based on the original journal article Carr, Martin, Cotton, Samuel, Földvári, Mihály, Kotrba, Marion (2006): A description of a new species of Diasemopsis (Diptera, Diopsidae) from the Comoro Islands with morphological, molecular and allometric data. Zootaxa 1211: 1-19, DOI: 10.5281/zenodo.172483

Packaging Health Services When Resources Are Limited: The Example of a Cervical Cancer Screening Visit

BackgroundIncreasing evidence supporting the value of screening women for cervical cancer once in their lifetime, coupled with mounting interest in scaling up successful screening demonstration projects, present challenges to public health decision makers seeking to take full advantage of the single-visit opportunity to provide additional services. We present an analytic framework for packaging multiple interventions during a single point of contact, explicitly taking into account a budget an...

Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method

The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential activation/deactivation of membrane-bound and cytosolic components. As such, it provides particularly interesting challenges for a combined computational and experimental analysis. We developed a novel detailed molecular signaling model that, when used to simulate the response to the attractant cyclic adenos...

Ring-Opening Polymerization of Lactides Initiated by Zinc Alkoxides Derived from NNO-Tridentate Ligands

Chen, Hsuan-Ying; Tang, Hui-Yi; Lin, Chu-Chieh (2006)
Publisher: Figshare
A new series of dinuclear zinc complexes of the types [LZnEt]2 and [LZn(μ-OBn)]2 (where L = NNO-tridentate Schiff base ligand) have been prepared. The activities of zinc alkoxides, [LZn(μ-OBn)]2, toward the ring-opening polymerization of l-lactide have been investigated. Experimental results indicate that the reactivity of [LZn(μ-OBn)]2 was dramatically affected by both the electronic and steric effect of the substituents on the Schiff base. The polymerization kinetics using [LZn(...

Computational Inference of Neural Information Flow Networks

Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow have been made using linear computational methods, but neural interactions are known to be nonlinear. Here, we demonstrate that a dynamic Bayesian network (DBN) inference algorithm we originally developed to infer nonlinear transcriptional regulatory networks from gene expres...

Initiation, Establishment, and Maintenance of Heritable MuDR Transposon Silencing in Maize Are Mediated by Distinct Factors

Paramutation and transposon silencing are two epigenetic phenomena that have intrigued and puzzled geneticists for decades. Each involves heritable changes in gene activity without changes in DNA sequence. Here we report the cloning of a gene whose activity is required for the maintenance of both silenced transposons and paramutated color genes in maize. We show that this gene, Mop1 (Mediator of paramutation1) codes for a putative RNA-dependent RNA polymerase, whose activity is required for t...

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages

BackgroundThe global spread of multidrug–resistant malaria parasites has led to an urgent need for new chemotherapeutic agents. Drug discovery is primarily directed to the asexual blood stages, and few drugs that are effective against the obligatory liver stages, from which the pathogenic blood infection is initiated, have become available since primaquine was deployed in the 1950s. Methods and FindingsUsing bioassay-guided fractionation based on the parasite's hepatic stage, we have isolated...

Seed Dispersal and Spatial Pattern in Tropical Trees

G Seidler, Tristram; B Plotkin, Joshua (2006)
Publisher: Figshare
Theories of tropical tree diversity emphasize dispersal limitation as a potential mechanism for separating species in space and reducing competitive exclusion. We compared the dispersal morphologies, fruit sizes, and spatial distributions of 561 tree species within a fully mapped, 50-hectare plot of primary tropical forest in peninsular Malaysia. We demonstrate here that the extent and scale of conspecific spatial aggregation is correlated with the mode of seed dispersal. This relationship ho...