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1635 research data, page 1 of 164

Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens

Retroviral insertional mutagenesis screens, which identify genes involved in tumor development in mice, have yielded a substantial number of retroviral integration sites, and this number is expected to grow substantially due to the introduction of high-throughput screening techniques. The data of various retroviral insertional mutagenesis screens are compiled in the publicly available Retroviral Tagged Cancer Gene Database (RTCGD). Integrally analyzing these screens for the presence of common...

Syntheses and X-ray Crystal Structures of Zirconium(IV) and Hafnium(IV) Complexes Containing Monovacant Wells−Dawson and Keggin Polyoxotungstates

The syntheses and crystal structures of a series of zirconium(IV) and hafnium(IV) complexes with Dawson monovacant phosphotungstate [α2-P2W17O61]10- and in situ-generated Keggin monovacant phosphotungstate [α-PW11O39]7-, which was obtained by a reaction of [α-PW12O40]3- with Na2CO3, are described. K15H[Zr(α2-P2W17O61)2]·25H2O (K-1), K16[Hf(α2-P2W17O61)2]·19H2O (K-2), (Et2NH2)10[Zr(α-PW11O39)2]·7H2O (Et2NH2-3), and (Et2NH2)10[Hf(α-PW11O39)2]·2H2O (Et2NH2-4), being afforded by reaction...

Moving Forward Moving Backward: Directional Sorting of Chemotactic Cells due to Size and Adhesion Differences

Differential movement of individual cells within tissues is an important yet poorly understood process in biological development. Here we present a computational study of cell sorting caused by a combination of cell adhesion and chemotaxis, where we assume that all cells respond equally to the chemotactic signal. To capture in our model mesoscopic properties of biological cells, such as their size and deformability, we use the Cellular Potts Model, a multiscale, cell-based Monte Carlo model. ...

Analysis of Ribosomal Protein Gene Structures: Implications for Intron Evolution

Many spliceosomal introns exist in the eukaryotic nuclear genome. Despite much research, the evolution of spliceosomal introns remains poorly understood. In this paper, we tried to gain insights into intron evolution from a novel perspective by comparing the gene structures of cytoplasmic ribosomal proteins (CRPs) and mitochondrial ribosomal proteins (MRPs), which are held to be of archaeal and bacterial origin, respectively. We analyzed 25 homologous pairs of CRP and MRP genes that together ...

Imitating Manual Curation of Text-Mined Facts in Biomedicine

Text-mining algorithms make mistakes in extracting facts from natural-language texts. In biomedical applications, which rely on use of text-mined data, it is critical to assess the quality (the probability that the message is correctly extracted) of individual facts—to resolve data conflicts and inconsistencies. Using a large set of almost 100,000 manually produced evaluations (most facts were independently reviewed more than once, producing independent evaluations), we implemented and tested...

The Effect of Steric Hindrance on the Association of Telluradiazoles through Te−N Secondary Bonding Interactions

DFT calculations were used to compare the magnitude of steric repulsion to the strength of secondary bonding interactions (SBIs) in the (Te−N)2 supramolecular synthon to explain or predict the supramolecular structures assembled by two derivatives of the 1,2,5-telluradiazole ring:  benzo-2,1,3-telluradiazole (4c) and 3,6-dibromobenzo-2,1,3-telluradiazole (5). The crystallographically determined structures were consistent with the computational predictions. In sharp contrast with the ...

Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis

The first examples of catalytic asymmetric ring-closing metathesis (ARCM) reactions of enol ethers are reported. To identify the most effective catalysts, various chiral Mo- and Ru-based catalysts were screened. Although chiral Ru catalysts (those that do not bear a phosphine ligand) promote ARCM in some cases, such transformations proceed in 98%).

Chromogenic Oxazines for Cyanide Detection

We have designed two heterocyclic compounds for the colorimetric detection of cyanide. The skeleton of both molecules fuses a benzooxazine ring to an indoline fragment and can be assembled efficiently in three synthetic steps starting from commercial precursors. The two compounds differ in the nature of the substituent on the carbon atom at the junction of the fused heterocycles, which can be either a methyl or a phenyl group. In the presence of cyanide, both molecules are convert...

Similarity Selection and the Evolution of Sex: Revisiting the Red Queen

F. Agrawal, Aneil (2006)
Publisher: Figshare
For over 25 years, many evolutionary ecologists have believed that sexual reproduction occurs because it allows hosts to change genotypes each generation and thereby evade their coevolving parasites. However, recent influential theoretical analyses suggest that, though parasites can select for sex under some conditions, they often select against it. These models assume that encounters between hosts and parasites are completely random. Because of this assumption, the fitness of a host depends ...

The Uncoupling Protein 1 Gene (UCP1) Is Disrupted in the Pig Lineage: A Genetic Explanation for Poor Thermoregulation in Piglets

Berg, Frida; Gustafson, Ulla; Andersson, Leif (2006)
Publisher: Figshare
Piglets appear to lack brown adipose tissue, a specific type of fat that is essential for nonshivering thermogenesis in mammals, and they rely on shivering as the main mechanism for thermoregulation. Here we provide a genetic explanation for the poor thermoregulation in pigs as we demonstrate that the gene for uncoupling protein 1 (UCP1) was disrupted in the pig lineage. UCP1 is exclusively expressed in brown adipose tissue and plays a crucial role for thermogenesis by uncoupling oxidative ph...