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3494 research data, page 1 of 350

Model comparisons and parameter estimates under models of constant (H0) or variable ω rate ratios across branches (Br), clades (H1 to H3) or both clades and sites (A and B) for the ε subunit.

Martyniuk, Christopher J.; Aris-Brosou, Stéphane; Drouin, Guy; Cahn, Joel; Trudeau, Vance L. (2007)
Publisher: Figshare
Notes–ℓ: log-likelihood value; HA: alternative hypothesis to the current model; ω0: background rate; ω1–5: branch/clade specific rates as indicated in Figure 4; p0–2: proportions of sites in each rate category. The hat notation indicates parameters that are free to vary. Positively selected sites were identified with BEB and NEB between brackets for model A and NEB only for model B; a 95% cut-off level of posterior probability was used. Sites putatively under positive selection are numbered a...

Effect of a Simple Information Booklet on Pain Persistence after an Acute Episode of Low Back Pain: A Non-Randomized Trial in a Primary Care Setting

Coudeyre, Emmanuel; Tubach, Florence; Rannou, François; Baron, Gabriel; Coriat, Fernand; Brin, Sylvie; Revel, Michel; Poiraudeau, Serge (2007)
Publisher: Figshare
ObjectiveMass-media campaigns have been known to modify the outcome of low back pain (LBP). We assessed the impact on outcome of standardized written information on LBP given to patients with acute LBP.MethodsDesign: A 3-month pragmatic, multicenter controlled trial with geographic stratification. Setting: Primary care practice in France. Participants: 2752 patients with acute LBP. Intervention: An advice book on LBP (the “back book”). Main outcome measures: The main outcome measure was persi...

Significant differences resulting from the interaction contrasts Intensity (Painful>Non-painful)>Unpleasantness (Painful>Non-painful) and vice versa.

Lamm, Claus; C. Nusbaum, Howard; N. Meltzoff, Andrew; Decety, Jean (2007)
Publisher: Figshare
Notes: Voxel threshold P = 0.001 (uncorrected), cluster size threshold k = 5. * P = 0.005, k = 5; stereotactic coordinates and t-values are provided for the local voxel maximum of the respective cluster. x = sub-peaks of a cluster, L = left hemisphere, R = right hemisphere, M = medial activation, k = number of activated voxels in cluster; areas (in brackets, e.g. OP4) determined based upon cytoarchitectonic maps provided in the Anatomy Toolbox.

ADAM33, a New Candidate for Psoriasis Susceptibility

Lesueur, Fabienne; Oudot, Tiphaine; Heath, Simon; Foglio, Mario; Lathrop, Mark; Prud'homme, Jean-François; Fischer, Judith (2007)
Publisher: Figshare
Psoriasis is a chronic skin disorder with multifactorial etiology. In a recent study, we reported results of a genome-wide scan on 46 French extended families presenting with plaque psoriasis. In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13. To follow up this novel psoriasis susceptibility locus we used a family-based association test (FBAT) for an association scan over the 17 M...

Quantitative Characteristics of Gene Regulation by Small RNA

Levine, Erel; Zhang, Zhongge; Kuhlman, Thomas; Hwa, Terence (2007)
Publisher: Figshare
An increasing number of small RNAs (sRNAs) have been shown to regulate critical pathways in prokaryotes and eukaryotes. In bacteria, regulation by trans-encoded sRNAs is predominantly found in the coordination of intricate stress responses. The mechanisms by which sRNAs modulate expression of its targets are diverse. In common to most is the possibility that interference with the translation of mRNA targets may also alter the abundance of functional sRNAs. Aiming to understand the unique role...

Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk

J. Welch, Timothy; Florian Fricke, W.; F. McDermott, Patrick; G. White, David; Rosso, Marie-Laure; A. Rasko, David; K. Mammel, Mark; Eppinger, Mark; Rosovitz, M.J.; Wagner, David; Rahalison, Lila; Eugene LeClerc, J.; M. Hinshaw, Jeffrey; E. Lindler, Luther; A. Cebula, Thomas;... (2007)
Publisher: Figshare
Antimicrobial resistance in Yersinia pestis is rare, yet constitutes a significant international public health and biodefense threat. In 1995, the first multidrug resistant (MDR) isolate of Y. pestis (strain IP275) was identified, and was shown to contain a self-transmissible plasmid (pIP1202) that conferred resistance to many of the antimicrobials recommended for plague treatment and prophylaxis. Comparative analysis of the DNA sequence of Y. pestis plasmid pIP1202 revealed a near identical ...

Development gene fold-changes in expression profiles.

S.D. Kothapalli, Kumar; C. Anthony, Joshua; Pan, Bruce S.; T. Hsieh, Andrea; W. Nathanielsz, Peter; Brenna, J. Thomas (2007)
Publisher: Figshare
Development gene fold-changes in expression profiles.

Percentage of caged females that mated for each cross in the 2003 Brood IX and 2004 Brood X experiments.*

M. Fontaine, Kathryn; R. Cooley, John; Simon, Chris (2007)
Publisher: Figshare
*An (-) indicates that that cross was not performed. Better weather may account for the increased mating frequency in Brood X when compared to Brood IX.

Homology nomenclature and expression of Hox/ParaHox-like genes in Cnidaria.

Jakob, Wolfgang; Schierwater, Bernd (2007)
Publisher: Figshare
Putative homology assignment of Cnox genes according to Gauchat et al. (2000) [43], Finnerty et al. (2003) [21] and Kuhn et al. (1996) [18].

Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern

Selman, Moisés; Carrillo, Guillermo; Estrada, Andrea; Mejia, Mayra; Becerril, Carina; Cisneros, José; Gaxiola, Miguel; Pérez-Padilla, Rogelio; Navarro, Carmen; Richards, Thomas; Dauber, James; E. King Jr, Talmadge; Pardo, Annie; Kaminski, Naftali (2007)
Publisher: Figshare
BackgroundIdiopathic pulmonary fibrosis (IPF) is characterized by the insidious onset of dyspnea or cough. However, a subset of patients has a short duration of symptoms with rapid progression to end-stage disease. In this study, we evaluated clinical and molecular features of “rapid” and “slow” progressors with IPF.Methods and Findings26 patients with 24 months of symptoms [slow progressors] were studied. Survival was analyzed by the Kaplan-Meyer method and proportional hazard's model. Lung ...