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3431 research data, page 1 of 344

Impact of HIV on Cell Survival and Antiviral Activity of Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDCs) are important mediators of innate immunity that act mainly through secretion of interferon (IFN)-α. Previous studies have found that these cells can suppress HIV in vitro; additionally, pDCs have been shown to be severely reduced in the peripheral blood of HIV-infected individuals. In the present study, we sought to determine the ability of pDCs to directly suppress viral replication ex vivo and to delineate the potential mechanisms whereby pDCs are deplete...

Percentage of caged females that mated for each cross in the 2003 Brood IX and 2004 Brood X experiments.*

*An (-) indicates that that cross was not performed. Better weather may account for the increased mating frequency in Brood X when compared to Brood IX.

Evolution of Antiretroviral Drug Costs in Brazil in the Context of Free and Universal Access to AIDS Treatment

BackgroundLittle is known about the long-term drug costs associated with treating AIDS in developing countries. Brazil's AIDS treatment program has been cited widely as the developing world's largest and most successful AIDS treatment program. The program guarantees free access to highly active antiretroviral therapy (HAART) for all people living with HIV/AIDS in need of treatment. Brazil produces non-patented generic antiretroviral drugs (ARVs), procures many patented ARVs with negotiated pr...

Cation−Anion Interactions and Polar Structures in the Solid State

Complicated structures where oxygen and fluorine are found together in one framework, where deviations from Pauling's second crystal rule (PSCR) are expected, often result in structures with important physical properties. The [NbOF5]2- anion and therefore all the individual Nb−O and Nb−F bonds are ordered in noncentrosymmetric KNaNbOF5 and centrosymmetric CsNaNbOF5. The Na/K− and Na/Cs−O/F interactions in these phases, in particular the expected deviations from PSCR and the bond v...

Range of the variation for the estimated parameters in the 1000 parameter sets

Zi, Zhike; Klipp, Edda (2007)
Publisher: Figshare
The values of the 1000 parameter sets obtained by each method are available in Table S1 and Table S2

Horizon at station Tamanrasset

Mimouni, Mohamed (2007)
Publisher: PANGAEA - Data Publisher for Earth & Environmental Science

Experimental Comparison and Evaluation of the Affymetrix Exon and U133Plus2 GeneChip Arrays

BackgroundAffymetrix exon arrays offer scientists the only solution for exon-level expression profiling at the whole-genome scale on a single array. These arrays feature a new chip design with no mismatch probes and a radically new random primed protocol to generate sense DNA targets along the entire length of the transcript. In addition to these changes, a limited number of validating experiments and virtually no experimental data to rigorously address the comparability of all-exon arrays wi...

Predicting Gene Expression from Sequence: A Reexamination

YUAN, YUAN; Guo, Lei; Shen, Lei; S. Liu, Jun (2007)
Publisher: Figshare
Although much of the information regarding genes' expressions is encoded in the genome, deciphering such information has been very challenging. We reexamined Beer and Tavazoie's (BT) approach to predict mRNA expression patterns of 2,587 genes in Saccharomyces cerevisiae from the information in their respective promoter sequences. Instead of fitting complex Bayesian network models, we trained naïve Bayes classifiers using only the sequence-motif matching scores provided by BT. Our simple model...

Pseudogene verification among diverse bovine-associated SA isolates

P = pseudogene conserved as in ET3-1D = divergent sequence, possibly pseudogene but different than ET3-1C = conserved sequence, not pseudogene, matches human SA isolates