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3463 research data, page 1 of 347

Association between the ACCN1 Gene and Multiple Sclerosis in Central East Sardinia

Multiple genome screens have been performed to identify regions in linkage or association with Multiple Sclerosis (MS, OMIM 126200), but little overlap has been found among them. This may be, in part, due to a low statistical power to detect small genetic effects and to genetic heterogeneity within and among the studied populations. Motivated by these considerations, we studied a very special population, namely that of Nuoro, Sardinia, Italy. This is an isolated, old, and genetically homogene...

Bub1 Is a Fission Yeast Kinetochore Scaffold Protein, and Is Sufficient to Recruit other Spindle Checkpoint Proteins to Ectopic Sites on Chromosomes

The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors. Checkpoint models propose that Mad1 and Bub1 act as stable kinetochore-bound scaffolds, to enhance recruitment of Mad2 and Mad3/BubR1, but this remains untested for Bub1. Here, fission yeast FRAP experiments confirm that Bub1 stably binds kinetochores, and by tet...

Taxonomy of the catfish genus Pseudoplatystoma Bleeker (Siluriformes: Pimelodidae) with recognition of eight species.

crawler.gbif.org (2007)
Publisher: GBIF Secretariat
This dataset contains the digitized treatments in Plazi based on the original journal article Uriel Angel Buitrago-Suárez, Brooks M. Burr (2007): Taxonomy of the catfish genus Pseudoplatystoma Bleeker (Siluriformes: Pimelodidae) with recognition of eight species. Zootaxa 1512: 1-38, URL: http://www.zoobank.org/urn:lsid:zoobank.org:pub:A7987452-69A5-4C79-B0F2-29B889EA3E1B

Neuroarchitecture of Peptidergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster

Recent studies on Drosophila melanogaster and other insects have revealed important insights into the functions and evolution of neuropeptide signaling. In contrast, in- and output connections of insect peptidergic circuits are largely unexplored. Existing morphological descriptions typically do not determine the exact spatial location of peptidergic axonal pathways and arborizations within the neuropil, and do not identify peptidergic in- and output compartments. Such information is however ...

Identification of a CCR5-Expressing T Cell Subset That Is Resistant to R5-Tropic HIV Infection

Infection with HIV-1 perturbs homeostasis of human T cell subsets, leading to accelerated immunologic deterioration. While studying changes in CD4+ memory and naïve T cells during HIV-1 infection, we found that a subset of CD4+ effector memory T cells that are CCR7−CD45RO−CD45RA+ (referred to as TEMRA cells), was significantly increased in some HIV-infected individuals. This T cell subset displayed a differentiated phenotype and skewed Th1-type cytokine production. Despite expressing high lev...

A Randomized Trial Evaluating Prosaptide™ for HIV-Associated Sensory Neuropathies: Use of an Electronic Diary to Record Neuropathic Pain

ObjectivesTo examine the efficacy and safety of Prosaptide™ (PRO) for the treatment of painful HIV-associated sensory neuropathies (HIV-SN).DesignA randomized, double-blind, placebo-controlled, multicenter study in participants with sensory neuropathy. Pain modulating therapy was discontinued prior to baseline. Participants were stratified by sural sensory nerve action potential (SNAP) amplitude. Participants were trained to use an electronic diary (ED) to record pain.SettingPeripheral neurop...

Definitions of the parameters and symbols used in the model.

Note that on the island individuals with genotype T2 have a (1+s)-times higher probability to survive than T1 individuals. Furher, females of genotype P2 mate a2 times more often with T2 males than with T1 males. In our simulations P1 females show no mating discrimination (a1 = 1).

Large-Scale Evaluation of Candidate Genes Identifies Associations between VEGF Polymorphisms and Bladder Cancer Risk

Common genetic variation could alter the risk for developing bladder cancer. We conducted a large-scale evaluation of single nucleotide polymorphisms (SNPs) in candidate genes for cancer to identify common variants that influence bladder cancer risk. An Illumina GoldenGate assay was used to genotype 1,433 SNPs within or near 386 genes in 1,086 cases and 1,033 controls in Spain. The most significant finding was in the 5′ UTR of VEGF (rs25648, p for likelihood ratio test, 2 degrees of freedom =...

In-line short cavity Fabry-Perot strain sensor for quasi distributed measurement utilizing standard OTDR

Edvard Cibula; Denis Donlagic (2007)
Publisher: Figshare
This paper presents an in-line, short cavity Fabry-Perot fiber optic strain sensor. A short air cavity inside a single-mode fiber is created by the fusion splicing of appropriately micro machined fiber tips. A precise tuning of the cavity length is introduced and used for the setting of the sensor static characteristics within the quasi-linear range around a quadrature point, which significantly simplifies signal processing. Sensor insertion losses achieved by short cavity design and optimize...

Magnetostratigraphy of ODP Site 177-1092 (Table 1), supplement to: Evans, Helen F; Westerhold, Thomas; Paulsen, Harald; Channell, James E T (2007): Astronomical ages for Miocene polarity chrons C4Ar-C5r (9.3-11.2 Ma), and for three excursion chrons within C5n.2n. Earth and Planetary Science Letters, 256(3-4), 455-465

Evans, Helen F.; Westerhold, Thomas; Paulsen, Harald; Channell, James E.T. (2007)
Publisher: PANGAEA - Data Publisher for Earth & Environmental Science
Ocean Drilling Program (ODP) Site 1092 from the sub-Antarctic South Atlantic produced a clear magnetic stratigraphy for the Late Miocene [Evans et al., 2003, doi:10.1046/j.1365-246X.2003.01916.x]. Three short intervals of reverse polarity were identified within the long (~1 Myr) normal polarity subchron C5n.2n. These excursion chrons were tentatively correlated to the three "cryptochrons" identified within subchron C5n.2n from NE Pacific marine magnetic anomaly data. New oxygen isotope data f...