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7176 research data, page 1 of 718

The Impact of Monitoring HIV Patients Prior to Treatment in Resource-Poor Settings: Insights from Mathematical Modelling

BackgroundThe roll-out of antiretroviral treatment (ART) in developing countries concentrates on finding patients currently in need, but over time many HIV-infected individuals will be identified who will require treatment in the future. We investigated the potential influence of alternative patient management and ART initiation strategies on the impact of ART programmes in sub-Saharan Africa. Methods and FindingsWe developed a stochastic mathematical model representing disease progression, d...

Systems Analysis Unfolds the Relationship between the Phosphoketolase Pathway and Growth in Aspergillus nidulans

BackgroundAspergillus nidulans is an important model organism for studies on fundamental eukaryotic cell biology and on industrial processes due to its close relation to A. niger and A. oryzae. Here we identified the gene coding for a novel metabolic pathway in A. nidulans, namely the phosphoketolase pathway, and investigated the role of an increased phosphoketolase activity.Methodology/Principal FindingsOver-expression of the phosphoketolase gene (phk) improved the specific growth rate on xy...

Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans

A. Evans, Eric; Kawli, Trupti; Tan, Man-Wah (2008)
Publisher: Figshare
Some pathogens have evolved mechanisms to overcome host immune defenses by inhibiting host defense signaling pathways and suppressing the expression of host defense effectors. We present evidence that Pseudomonas aeruginosa is able to suppress the expression of a subset of immune defense genes in the animal host Caenorhabditis elegans by activating the DAF-2/DAF-16 insulin-like signaling pathway. The DAF-2/DAF-16 pathway is important for the regulation of many aspects of organismal physiology...

Allergen Uptake, Activation, and IL-23 Production by Pulmonary Myeloid DCs Drives Airway Hyperresponsiveness in Asthma-Susceptible Mice

Maladaptive, Th2-polarized inflammatory responses are integral to the pathogenesis of allergic asthma. As regulators of T cell activation, dendritic cells (DCs) are important mediators of allergic asthma, yet the precise signals which render endogenous DCs “pro-asthmatic”, and the extent to which these signals are regulated by the pulmonary environment and host genetics, remains unclear. Comparative phenotypic and functional analysis of pulmonary DC populations in mice susceptible (A/J), or r...

Genetic risk associated with the different HLA-DQ molecules

b) Combinations of the DQ molecules on the two chromosomes, the number of functional copies and the genetic risk associated to coeliac disease (calculated using the CD cohort and the blood bank control cohort).*This risk increases to 4.1 in the DQ2.5 negative group.

URE3 motif in promoters of genes modulated by a dominant positive URE3-BP

Identity (Pathema Locus number) and gene annotation of significantly modulated genes are shown in conjunction with the observed change between induced EF(2)mutURE3-BP and STOP- EF(2)mutURE3-BP strains. The distance between the URE3 motif and the presumed initiating ATG codon is shown as is the position of other potential URE3 motifs, the promoter consensus URE3 motif, and orientation.1If the motif is present in the promoter in a 5′ to 3′ direction this is indicated by (+) and on the reverse s...

Significantly correlated ratios of metabolite concentration with smoker phenotype

Two metabolites M1 and M2 are listed in the first two columns. Pearson's correlation coefficient r of metabolite ratios of M1/M2 and M2/M1 positively and negatively correlated with smoker phenotype are shown in columns 4 and 6, respectively. The corresponding p-values of n-cases of t-tests are indicated in columns 5 and 7, respectively.

Microneutralization (MNt) assay.

*Whole IgG1 was used for all antibodies in this assay.**Reciprocals of the highest dilutions of Abs that showed less than 50% cytopathic effects in 2 of the 3 wells tested.

Identification of G1-Regulated Genes in Normally Cycling Human Cells

BackgroundObtaining synchronous cell populations is essential for cell-cycle studies. Methods such as serum withdrawal or use of drugs which block cells at specific points in the cell cycle alter cellular events upon re-entry into the cell cycle. Regulatory events occurring in early G1 phase of a new cell cycle could have been overlooked.Methodology and FindingsWe used a robotic mitotic shake-off apparatus to select cells in late mitosis for genome-wide gene expression studies. Two separate m...