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10967 research data, page 1 of 1097

Biological validation of identified genes.

Wild-type (N2) and mutant C. elegans strains were grown on the four bacterial isolates and absolute fitness (λ) and time to death for 50% of the individuals in a population (TD50 in days) was measured. P-values are shown for contrasts between environments within strain for λ and TD50. Standard error (s.e.m.) is given in parenthesis. + indicates a significant (P

A Fast Photochromic Molecule That Colors Only under UV Light

Kishimoto, Yuta; Abe, Jiro (2009)
Publisher: Figshare
A Fast Photochromic Molecule That Colors Only under UV Light

Number of studies presenting numerical data.

†99% (267/271) of the included studies presented numerical data. The study was scored “Yes” if numerical data were presented graphically, in tabular form or in the text, either for each animal or by treatment group.

Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer

Hsp90 is a molecular chaperone essential for protein folding and activation in normal homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational changes required for client activation. Hsp90 plays an important role in disease states, particularly in cancer, where chaperoning of the mutated and overexpressed oncoproteins is important for function. Recent studies have illuminated mechanisms related to the chaperone function. However, an atomic resolution view of...

Functional redundancy between sufA, iscA and erpA.

1All strains were grown overnight aerobically in LB medium supplemented with arabinose (0.2%), thiamine (50 µg/ml), nicotinic acid (12.5 µg/ml) and mevalonate (Mev, 1 mM) then plated on the same medium with or without mevalonate. The plates were incubated at 37°C aerobically (+O2) or in limiting oxygen (−O2) for 3 days before counting. Plating efficiency was calculated as the ratio: number of colonies formed in tested conditions/number of colonies formed aerobically on LB plates containing me...

Use of Bacterially Expressed dsRNA to Downregulate Entamoeba histolytica Gene Expression

BackgroundModern RNA interference (RNAi) methodologies using small interfering RNA (siRNA) oligonucleotide duplexes or episomally synthesized hairpin RNA are valuable tools for the analysis of gene function in the protozoan parasite Entamoeba histolytica. However, these approaches still require time-consuming procedures including transfection and drug selection, or costly synthetic molecules.Principal FindingsHere we report an efficient and handy alternative for E. histolytica gene down-regul...

Heterochronic Shift in Hox-Mediated Activation of Sonic hedgehog Leads to Morphological Changes during Fin Development

We explored the molecular mechanisms of morphological transformations of vertebrate paired fin/limb evolution by comparative gene expression profiling and functional analyses. In this study, we focused on the temporal differences of the onset of Sonic hedgehog (Shh) expression in paired appendages among different vertebrates. In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, concomitant with Hoxd10 expression. In dogfish (Scyliorhinus canicu...

Interference with Hemozoin Formation Represents an Important Mechanism of Schistosomicidal Action of Antimalarial Quinoline Methanols

BackgroundThe parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel remains the main drug used for schistosomiasis treatment, and reliance on the single therapy has been prompting the search for new therapeutic compounds against this disease. Our group has demonstrated that heme crystallization into hemozoin (Hz) within the S. mansoni gut is a major heme detoxification route with lipid d...

Summary of population genetic data collected for the genes encoding twelve P. falciparum vaccine antigens.

*Source: PlasmoDB, www.plasmodb.org.†gaps were deleted.‡analysis was done only with 5 amino acid polymorphisms, n = number of sequences; dN = number of nonsynonymous polymorphisms; number of synonymous polymorphisms; n.d. = not done.