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16823 research data, page 1 of 1683

Germline Variation Controls the Architecture of Somatic Alterations in Tumors

M. Dworkin, Amy; Ridd, Katie; Bautista, Dianne; C. Allain, Dawn; Hans Iwenofu, O.; Roy, Ritu; C. Bastian, Boris; Ewart Toland, Amanda (2010)
Publisher: Figshare
Studies have suggested that somatic events in tumors can depend on an individual's constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and across individuals. Specifically, we performed array comparative genomic hybridization on 104 tumors from 25 unrelated individuals who each had three or more independently arisen SCCs and compared the pro...

Characteristics of DCM cases and controls used for initial screening.

Stark, Klaus; B. Esslinger, Ulrike; Reinhard, Wibke; Petrov, George; Winkler, Thomas; Komajda, Michel; Isnard, Richard; Charron, Philippe; Villard, Eric; Cambien, François; Tiret, Laurence; Aumont, Marie-Claude; Dubourg, Olivier; Trochu, Jean-Noël; Fauchier, Laurent;... (2010)
Publisher: Figshare
Values denote means ± standard deviations (range) unless indicated otherwise. n. a., not available; LVEF, left ventricular ejection fraction; BMI, body mass index.aDefined as blood pressure ≥140/90 mmHg or ongoing antihypertensive therapy.bDefined as LDL cholesterol ≥160 mg/dL or intake of lipid lowering medication.cDefined as self-reported history of diabetes mellitus or intake of antidiabetic medication.dFormer or current smoking habit including current occasionally smokers.

Reactive Oxygen Species (ROS) neutralization in H2O2 stressed HaCaT cells.

Simmler, Charlotte; Antheaume, Cyril; Lobstein, Annelise (2010)
Publisher: Figshare
Intracellular antioxidant property of stilbenoids 1–3 was evaluated on H2O2 stressed HaCaT by measuring ROS neutralization with DCFH-DA probe. Results are expressed as IC50 (mean ± sd) determined for global ROS neutralization on HaCaT. IC50 concentration causing half-maximal neutralization of intracellular ROS. Quercetin was used as a standard reference.

A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses

W. Hill, Emmeline; Gu, Jingjing; S. Eivers, Suzanne; G. Fonseca, Rita; A. McGivney, Beatrice; Govindarajan, Preethi; Orr, Nick; M. Katz, Lisa; MacHugh, David (2010)
Publisher: Figshare
Variants of the MSTN gene encoding myostatin are associated with muscle hypertrophy phenotypes in a range of mammalian species, most notably cattle, dogs, mice, and humans. Using a sample of registered Thoroughbred horses (n = 148), we have identified a novel MSTN sequence polymorphism that is strongly associated (g.66493737C>T, P = 4.85×10−8) with best race distance among elite racehorses (n = 79). This observation was independently validated (P = 1.91×10−6) in a resampled group of Thoroughb...

Interaction and Modulation of Two Antagonistic Cell Wall Enzymes of Mycobacteria

Hett, Erik C.; C. Chao, Michael; J. Rubin, Eric (2010)
Publisher: Figshare
Bacterial cell growth and division require coordinated cell wall hydrolysis and synthesis, allowing for the removal and expansion of cell wall material. Without proper coordination, unchecked hydrolysis can result in cell lysis. How these opposing activities are simultaneously regulated is poorly understood. In Mycobacterium tuberculosis, the resuscitation-promoting factor B (RpfB), a lytic transglycosylase, interacts and synergizes with Rpf-interacting protein A (RipA), an endopeptidase, to ...

HIV Promoter Integration Site Primarily Modulates Transcriptional Burst Size Rather Than Frequency

Skupsky, Ron; Burnett, John C.; E. Foley, Jonathan; Schaffer, David V.; Arkin, Adam P. (2010)
Publisher: Figshare
Mammalian gene expression patterns, and their variability across populations of cells, are regulated by factors specific to each gene in concert with its surrounding cellular and genomic environment. Lentiviruses such as HIV integrate their genomes into semi-random genomic locations in the cells they infect, and the resulting viral gene expression provides a natural system to dissect the contributions of genomic environment to transcriptional regulation. Previously, we showed that expression ...

Combining ChIP-chip and Expression Profiling to Model the MoCRZ1 Mediated Circuit for Ca2+/Calcineurin Signaling in the Rice Blast Fungus

Kim, Soonok; Hu, Jinnan; Oh, Yeonyee; Park, Jongsun; Choi, Jinhee; Lee, Yong-Hwan; Dean, Ralph A.; K. Mitchell, Thomas (2010)
Publisher: Figshare
Significant progress has been made in defining the central signaling networks in many organisms, but collectively we know little about the downstream targets of these networks and the genes they regulate. To reconstruct the regulatory circuit of calcineurin signal transduction via MoCRZ1, a Magnaporthe oryzae C2H2 transcription factor activated by calcineurin dephosphorylation, we used a combined approach of chromatin immunoprecipitation - chip (ChIP-chip), coupled with microarray expression ...

Association p-values of TLR1 tSNPs with severe sepsis complications.

Pino-Yanes, María; Corrales, Almudena; Casula, Milena; Blanco, Jesus; Muriel, Arturo; Espinosa, Elena; García-Bello, Miguel; Torres, Antoni; Ferrer, Miguel; Zavala, Elizabeth; Villar, Jesús; Flores, Carlos (2010)
Publisher: Figshare
In parenthesis, p-value for a recessive model; nominal significances in bold.

ANK, a Host Cytoplasmic Receptor for the Tobacco mosaic virus Cell-to-Cell Movement Protein, Facilitates Intercellular Transport through Plasmodesmata

Ueki, Shoko; Spektor, Roman; M. Natale, Danielle; Citovsky, Vitaly (2010)
Publisher: Figshare
Plasmodesma (PD) is a channel structure that spans the cell wall and provides symplastic connection between adjacent cells. Various macromolecules are known to be transported through PD in a highly regulated manner, and plant viruses utilize their movement proteins (MPs) to gate the PD to spread cell-to-cell. The mechanism by which MP modifies PD to enable intercelluar traffic remains obscure, due to the lack of knowledge about the host factors that mediate the process. Here, we describe the ...

Crystallographic Data and Refinement Statistics.

A. Cooper, Colin; Zhang, Kun; Andres, Sara N.; Fang, Yuan; A. Kaniuk, Natalia; Hannemann, Mandy; H. Brumell, John; Foster, Leonard J.; Junop, Murray S.; Coombes, Brian K. (2010)
Publisher: Figshare
aData for the highest resolution shell are shown in parentheses.