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27710 research data, page 1 of 2771

Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension

Using a spectral domain OCT system, equipped with a broadband Ti:sapphire laser, we imaged the human retina with 5 µm x 1.3 µm transverse and axial resolution at acquisition rate of 100 kHz. Such imaging speed significantly reduces motion artifacts. Combined with the ultra-high resolution, this allows observing microscopic retinal details with high axial definition without the help of adaptive optics. In this work we apply our system to image the parafoveal capillary network. We demonstrate h...

Serum levels of total bile acids (A) and relative abundance of taurine- (B) and glycine- (C) conjugated species in non-cholestatic donors and patients with biliary obstruction before and after biliary stenting.

Bile acids were quantified as indicated in the “Experimental Procedures” section. Concentrations (A) and relative abundance of tauro- (B) and glyco-bile acids (C) in biliary stenosis patients (17 donors) before and after stenting were compared to those from a non-cholestatic group (40 volunteers). A: Total bile acids: sum of all 17 species. B: Percentage of taurine conjugates: sum of taurine-conjugated acids divided by the sum of all bile acids. C: Percentage of glycine conjugates: sum of gly...

Assay of TIC frequencies for Lrp5+ and Lrp cell subpopulations from Wnt-induced tumors.

Lrp5+ and Lrp5− (Lin−) cell fractions were purified by flow cytometry, assayed by isograft to mammary fat pads at limiting dilutions, and results were reported as for Table 1. Pairwise comparison of the Lrp+ and Lrp− cells shows that the TIC frequency is significantly different (* p = 2.34×10−5).

Brownian Dynamics Simulation of Nucleocytoplasmic Transport: A Coarse-Grained Model for the Functional State of the Nuclear Pore Complex

The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to the transport process is the hydrophobic interactions between karyopherins (kaps) and Phe-Gly (FG) repeat domains. Taking into account the polymeric nature of FG-repeats grafted on the elastic structure of the NPC, and the kap-FG hydrophobic ...

Killing of Targets by CD8+ T Cells in the Mouse Spleen Follows the Law of Mass Action

It has been difficult to correlate the quality of CD8 T cell responses with protection against viral infections. To investigate the relationship between efficacy and magnitude of T cell responses, we quantify the rate at which individual CD8 effector and memory T cells kill target cells in the mouse spleen. Using mathematical modeling, we analyze recent data on the loss of target cells pulsed with three different peptides from the mouse lymphocytic choriomeningitis virus (LCMV) in mouse splee...

Number of protein kinase genes with non-synonymous variants in each cell-line.

*at least 3 reads show the variation, and allele frequency for the variant > = 40%.

Honey Bee PTEN – Description, Developmental Knockdown, and Tissue-Specific Expression of Splice-Variants Correlated with Alternative Social Phenotypes

BackgroundPhosphatase and TENsin (PTEN) homolog is a negative regulator that takes part in IIS (insulin/insulin-like signaling) and Egfr (epidermal growth factor receptor) activation in Drosophila melanogaster. IIS and Egfr signaling events are also involved in the developmental process of queen and worker differentiation in honey bees (Apis mellifera). Here, we characterized the bee PTEN gene homologue for the first time and begin to explore its potential function during bee development and ...

Filaggrin Genotype Determines Functional and Molecular Alterations in Skin of Patients with Atopic Dermatitis and Ichthyosis Vulgaris

BackgroundSeveral common genetic and environmental disease mechanisms are important for the pathophysiology behind atopic dermatitis (AD). Filaggrin (FLG) loss-of-function is of great significance for barrier impairment in AD and ichthyosis vulgaris (IV), which is commonly associated with AD. The molecular background is, however, complex and various clusters of genes are altered, including inflammatory and epidermal-differentiation genes. ObjectiveThe objective was to study whether the functi...

Fetal pathology, clinical management and neonatal outcomes, N = 1076.

aRelative risk (95% Confidence Interval).bA baby with an adjusted birth weight below 2.5th percentile, or one ultrasound measurement