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28132 research data, page 1 of 2814

Date of isolation and resistance pattern of the different isolates of M. tuberculosis as tested in the BACTEC 460 system and antibiotic resistance mutations identified in isolates obtained from eight different time points.

H. Mariam, Solomon; Werngren, Jim; Aronsson, Joakim; Hoffner, Sven; I. Andersson, Dan (2011)
Publisher: Figshare
a: S = Susceptible, R = Resistant.wt = wild-type.b: Streptomycin-resistant isolates with wild-type rpsL were checked for mutation in rrs. The A513C mutation in rrs confers streptomycin resistance whereas the A1400G mutation confers amikacin resistance.

An Improved Transplantation Strategy for Mouse Mesenchymal Stem Cells in an Acute Myocardial Infarction Model

Jin, Jianliang; Zhao, Yingming; Tan, Xiao; Guo, Chun; Yang, Zhijian; Miao, Dengshun (2011)
Publisher: Figshare
To develop an effective therapeutic strategy for cardiac regeneration using bone marrow mesenchymal stem cells (BM-MSCs), the primary mouse BM-MSCs (1st BM-MSCs) and 5th passage BM-MSCs from β-galactosidase transgenic mice were respectively intramyocardially transplanted into the acute myocardial infarction (AMI) model of wild type mice. At the 6th week, animals/tissues from the 1st BM-MSCs group, the 5th passage BM-MSCs group, control group were examined. Our results revealed that, compared ...

Comparison of average AUC between BN classifiers trained on all available features vs. only TFBS-feature distances.

Wright, Hollis; Cohen, Aaron; Sönmez, Kemal; Yochum, Gregory; McWeeney, Shannon (2011)
Publisher: Figshare
Table 2 indicates the average AUC across 100 cross-validation classifiers constructed using all available predictors vs. the same classifiers when feature-feature data was excluded.

Symbols legend for Fig. 3.

Burioni, Raffaella; Scalco, Riccardo; Casartelli, Mario (2011)
Publisher: Figshare
Symbols legend for Fig. 3.

Mean ± SD of primary bleeding time relative to start of eupolytin1 or urokinase infusion.

Yang, Hailong; Wang, Yipeng; Xiao, Yao; Wang, Ying; Wu, Jing; Liu, Cunbao; Ye, Huahu; Li, Fengliang; Yu, Haining; Lai, Ren (2011)
Publisher: Figshare
Preatment times were −30, −10, and 0 minutes; treatment times, 10 and 30 minutes; and posttreatment times, 60, 90, 120 and 180 minutes.

Modelling of drug action.

Burghaus, Rolf; Coboeken, Katrin; Gaub, Thomas; Kuepfer, Lars; Sensse, Anke; Siegmund, Hans-Ulrich; Weiss, Wolfgang; Mueck, Wolfgang; Lippert, Joerg (2011)
Publisher: Figshare
Va, IIa, IXa, Xa and XIa denote activated coagulation factors. ATIII, antithrombin; BAY59-7939, rivaroxaban; fu, fraction unbound; Hep, heparin (here parameterized as enoxaparin); on, kon, association rate constant; mIIa, meizothrombin; Tm, thrombomodulin; Xim, ximelagatran active metabolite (mela...

mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction

Shiheido, Hirokazu; Takashima, Hideaki; Doi, Nobuhide; Yanagawa, Hiroshi (2011)
Publisher: Figshare
p53 is a tumor suppressor protein that prevents tumorigenesis through cell cycle arrest or apoptosis of cells in response to cellular stress such as DNA damage. Because the oncoprotein MDM2 interacts with p53 and inhibits its activity, MDM2-p53 interaction has been a major target for the development of anticancer drugs. While previous studies have used phage display to identify peptides (such as DI) that inhibit the MDM2-p53 interaction, these peptides were not sufficiently optimized because ...

Chemo- and Regioselectivity-Tunable Pd-Catalyzed Allylic Alkylation of Imines

Chen, Jian-Ping; Peng, Qian; Lei, Bai-Lin; Hou, Xue-Long; Wu, Yun-Dong (2011)
Publisher: Figshare
α-Carbanions of cyclic and acyclic imines have been successfully applied as nucleophiles in the Pd-catalyzed allylic alkylation reaction. Tuning of chemo- and regioselectivity has been realized by using t-BuOK/THF and LDA/toluene to give branched and linear products, respectively, with high regio- and diastereoselectivities. A plausible mechanism is proposed on the basis of the experimental results and DFT calculations.

Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs

Wan, Shuangyi; Wu, Fanghui; Rech, Jason C.; Green, Michael E.; Balachandran, Raghavan; Horne, W. Seth; Day, Billy W.; Floreancig, Paul E. (2011)
Publisher: Figshare
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages. This route allowed for the facile preparation of a number of analogs that were designed to explore the importance of the alkoxy group in the N-acyl aminal and functional groups in the two major subunits on biological activity. These analogs, ...

Residues that give the highest mean square fluctuation response (χj>1.00 for hPTP1E and PSD-95) upon perturbation by PRS analysis.

Gerek, Z. Nevin; Ozkan, S. Banu (2011)
Publisher: Figshare
Residues shown in boldface agree with experimentally identified ones.