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97523 research data, page 1 of 9753

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

Abstract Background DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. Results We use whole genome bisulfite sequencing, and find that differentiation of mouse colonic intestinal stem cells to intestinal epithelium is not associated with major changes in DNA methylation. However, we detect extensive dynamic epigenetic changes in intestinal stem cells and their p...

Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues

Abstract Introduction Pathologists currently diagnose breast lesions through histologic assessment, which requires fixation and tissue preparation. The diagnostic criteria used to classify breast lesions are qualitative and subjective, and inter-observer discordance has been shown to be a significant challenge in the diagnosis of selected breast lesions, particularly for borderline proliferative lesions. Thus, there is an opportunity to develop tools to rapidly visualize and quantitatively in...

Determinants of Direct and Indirect Costs in Anorexia Nervosa

Zipfel, Stephan (2015)
Publisher: Universitätsbibliothek Tübingen
Embargo end date: 2015/04/23

vsearch: VSEARCH version 1.0.16

Torbjørn Rognes; Frédéric Mahé; xflouris (2015)
Publisher: Zenodo
Integrate patches to the code from Debian

Healthcare system intervention for safer use of medicines in elderly patients in primary care—a qualitative study of the participants’ perceptions of self-assessment, peer review, feedback and agreement for change

Abstract Background The elderly population is increasing and with advanced age comes a higher risk for contracting diseases and excessive medicine use. Polypharmacy can lead to drug-related problems and an increased need of health care. More needs to be done to help overcome these problems. In order for new models to be successful and possible to implement in health care they have to be accepted by caregivers. The aim of this study was to evaluate participants’ perceptions of the SÄKLÄK proje...

Impact of Amphiphilic Biomass-Dissolving Ionic Liquids on Biological Cells and Liposomes

Lämmerhofer, Michael (2015)
Publisher: Universitätsbibliothek Tübingen
Embargo end date: 2015/04/15

Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

Abstract Background Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental conditions. We showed previously that mitochondria of cells in a low oxygen environment (hypoxia) hyperfuse to form enlarged or highly interconnected networks with enhanced metabolic efficacy and resistance to apoptosis. Modifications to the appearance and metabolic capa...