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85113 research data, page 1 of 8512

Barriers and enablers to diabetic retinopathy screening attendance: Protocol for a systematic review

Abstract Background Diabetic retinopathy is a serious complication of diabetes which, if left untreated, can result in blindness. Population screening among people with diabetes has been shown to be clinically effective; however, suboptimal attendance with wide demographic disparities has been reported. To develop quality improvement interventions to maximise attendance, it is important to understand the theoretical determinants (i.e. barriers and enablers) of screening behaviour. The aim of ...

Take-off flight performance in blue tits.

Laura McFarlane; John Altringham; Graham Askew (2016)
Publisher: University of Leeds
These data relate to an investigation into the effects of intra-specific variation in wing morphology on escape take-off perfromance in blue tits. As wing morphology varies seasonally and diurnally as a result of feather moult, feather wear and fluctuations in body mass, the aim was to determine whether this variation had an impact on a bird's take-off performance. The morphological and wing beat kinematic variables of individual birds are shown together with corresponding flight power requir...

Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma

Abstract Background Patient derived xenografts (PDX) are generated by transplanting the original patientâ s tumor tissue into immune-deficient mice. Unlike xenograft models derived from cell lines, PDX models can better preserve the histopathology from the original patient and molecular pathways. High-grade serous carcinoma (HGSC) is a deadly form of ovarian/fallopian tube cancer whose response to current chemotherapies varies widely due to patient variability. Therefore, a PDX model can pro...

A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials

Abstract Background Randomised controlled trials guard against selection bias and therefore offer the fairest way of evaluating healthcare interventions such as medicinal products, devices and services. Recruitment to trials can be extremely difficult, and poor recruitment can lead to extensions to both time and budget and may result in an underpowered study which does not satisfactorily answer the original research question. In the worst cases, a trial may be abandoned, causing huge waste. T...

An evolutionary roadmap to the microtubule-associated protein MAP Tau

Abstract Background The microtubule associated protein Tau (MAPT) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. Its neuronal expression and intrinsic disorder implicate it in some 30 tauopathies such as Alzheimerâ s disease and frontotemporal dementia. These pathophysiological studies have yet to be complemented by computational analyses of its molecular evolution and structural models of all its functional dom...

An indication of current views of Australian general practitioners towards chiropractic and osteopathy: a cross-sectional study

Roger Engel; Robyn Beirman; Sandra Grace (2016)
Publisher: Figshare
Abstract Background While the role of complementary medicine therapies such as chiropractic and osteopathy is yet to be clearly delineated in the Australian context, demand for these services remains high. The attitudes of general practitioners towards chiropractors and osteopaths may have played a part in producing this outcome. However, this view is based on data that were more than 10 years old. Current anecdotal evidence suggests that the previous level of support may be declining in sect...

Health behavior change in advance care planning: an agent-based model

Abstract Background A practical and ethical challenge in advance care planning research is controlling and intervening on human behavior. Additionally, observing dynamic changes in advance care planning (ACP) behavior proves difficult, though tracking changes over time is important for intervention development. Agent-based modeling (ABM) allows researchers to integrate complex behavioral data about advance care planning behaviors and thought processes into a controlled environment that is mor...

The passive leg raising test to guide fluid removal in critically ill patients

Abstract Background To investigate whether haemodynamic intolerance to fluid removal during intermittent renal replacement therapy (RRT) in critically ill patients can be predicted by a passive leg raising (PLR) test performed before RRT. Methods We included 39 patients where intermittent RRT with weight loss was decided. Intradialytic hypotension was defined as hypotension requiring a therapeutic intervention, as decided by the physicians in charge. Before RRT, the maximal increase in cardia...

pyGeno: a Python Package for Precision Medicine (1.2.8)

Tariq Daouda (2016)
Publisher: Zenodo
pyGeno is a personal bioinformatic database that runs directly into python, on your laptop and does not depend upon any REST API. The most exciting feature of pyGeno, is that it allows to work with seamlessly with both reference and Personalized Genomes. Personalized Genomes, are custom genomes that you create by combining a reference genome, sets of polymorphisms and an optional filter. pyGeno will take care of applying the filter and inserting the polymorphisms at their rig...

Potential for task-sharing to Lady Health Workers for identification and emergency management of pre-eclampsia at community level in Pakistan

Abstract Background An estimated 276 Pakistani women die for every 100,000 live births; with eclampsia accounting for about 10 % of these deaths. Community health workers contribute to the existing health system in Pakistan under the banner of the Lady Health Worker (LHW) Programme and are responsible to provide a comprehensive package of antenatal services. However, there is a need to increase focus on early identification and prompt diagnosis of pre-eclampsia in community settings, since w...