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96907 research data, page 1 of 9691

Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro

Alina Freiman; Yulia Shandalov; Dekel Rozenfeld; Erez Shor; Sofia Segal; Dror Ben-David; Shai Meretzki; Dana Egozi; Shulamit Levenberg (2016)
Publisher: Figshare
Abstract Background Adipose-derived mesenchymal stem cells (MSCs) have been gaining fame mainly due to their vast clinical potential, simple isolation methods and minimal donor site morbidity. Adipose-derived MSCs and microvascular endothelial cells have been shown to bear angiogenic and vasculogenic capabilities. We hypothesized that co-culture of human adipose-derived MSCs with human adipose-derived microvascular endothelial cells (HAMECs) will serve as an effective cell pair to induce angi...

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

Hideyuki Arita; Kai Yamasaki; Yuko Matsushita; Taishi Nakamura; Asanao Shimokawa; Hirokazu Takami; Shota Tanaka; Akitake Mukasa; Mitsuaki Shirahata; Saki Shimizu; Kaori Suzuki; Kuniaki Saito; Keiichi Kobayashi; Fumi Higuchi; Takeo Uzuka;... (2016)
Publisher: Figshare
Abstract The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding factors such as MGMT methylation status or patients’ treatment. This study aimed to evaluate the impact of TERT status on patient outcome in association with various factors in a large series of adult diffuse gliomas. We analyzed a total of 951 adult diffuse gliomas from two cohorts (Cohort 1, ...

Global health equity in United Kingdom university research: a landscape of current policies and practices

Dzintars Gotham; Jonathan Meldrum; Vaitehi Nageshwaran; Christopher Counts; Nina Kumari; Manuel Martin; Ben Beattie; Nathan Post (2016)
Publisher: Figshare
Abstract Background Universities are significant contributors to research and technologies in health; however, the health needs of the world’s poor are historically neglected in research. Medical discoveries are frequently licensed exclusively to one producer, allowing a monopoly and inequitable pricing. Similarly, research is often published in ways that make it inaccessible. Universities can adopt policies and practices to overcome neglect and ensure equitable access to research and its pro...

Revision of sinistral land snails of the genus Camaena (Stylommatophora, Camaenidae) from China based on morphological and molecular data, with description of a new species from Guangxi, China

Hong-Mu Ai (2016)
Publisher: Plazi.org taxonomic treatments database
This dataset contains the digitized treatments in Plazi based on the original journal article Ding, Hong-Li, Wang, Pei, Qian, Zhou-Xing, Lin, Jun-Hong, Zhou, Wei-Chuan, Hwang, Chung-Chi, Ai, Hong-Mu (2016): Revision of sinistral land snails of the genus Camaena (Stylommatophora, Camaenidae) from China based on morphological and molecular data, with description of a new species from Guangxi, China. ZooKeys 584: 25-48, DOI: http://dx.doi.org/10.3897/zookeys.584.7173, URL: http://dx.doi.org/10.3...

To mix or not to mix: comparing the predictive performance of mixture models vs. separate species distribution models

Francis K. C. Hui; David I. Warton; Scott D. Foster; Piers K. Dunstan (2016)
Publisher: Figshare
Species distribution models (SDMs) are an important tool for studying the patterns of species across environmental and geographic space. For community data, a common approach involves fitting an SDM to each species separately, although the large number of models makes interpretation difficult and fails to exploit any similarities between individual species responses. A recently proposed alternative that can potentially overcome these difficulties is species archetype models (SAMs), a model-ba...

Uniaxial creep test data for 14 MoV 6 3 material at 600 °C and a stress of 140 MPa

Ennis, PJ; Schuster, H; Forschungszentrum Juelich - IWE (2016)
Publisher: European Commission JRC
This data collection consists of uniaxial creep, uniaxial tensile, and elastic modulus results from tests performed on low-alloy steels at FZ Jülich in the scope of COST 501/II/WP5 C. With COST 501 Round II Work Package 5 concerned with the prediction of residual lifetime under simulated service loads, the WP5 C sub-package was focused on steam pipe steels.In the scope of the WP5 C sub-package, creep rupture testing of 13CrMo 4 4 (1Cr0.5Mo0.25V) and 14MoV 6 3 (0.5Cr0.5Mo0.25V) steels in new (...

Small (autonomic) and large fiber neuropathy in Parkinson disease and parkinsonism

Davi de Araújo; Antônio de Melo Neto; Ítalo Oliveira; Beatriz Brito; Ineusi de Araújo; Ingrid Barros; José Lima; Wagner Horta; Francisco Gondim (2016)
Publisher: Figshare
Abstract Background Recent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson’s disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit. Methods We evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT). In addition, we also performe...

Dietary silver nanoparticles can disturb the gut microbiota in mice

Sybille van den Brule; Jérôme Ambroise; Hélène Lecloux; Clément Levard; Romain Soulas; Pieter-Jan De Temmerman; Mihaly Palmai-Pallag; Etienne Marbaix; Dominique Lison (2016)
Publisher: Figshare
Abstract Background Humans are increasingly exposed via the diet to Ag nanoparticles (NP) used in the food industry. Because of their anti-bacterial activity, ingested Ag NP might disturb the gut microbiota that is essential for local and systemic homeostasis. We explored here the possible impact of dietary Ag NP on the gut microbiota in mice at doses relevant for currently estimated human intake. Methods Mice were orally exposed to food (pellets) supplemented with increasing doses of Ag NP (...

HABITAT MODIFICATION AND REFUGE FROM SUBLETHAL STRESS DRIVE A MARINE PLANT–HERBIVORE ASSOCIATION

Jennifer L. Burnaford (2016)
Publisher: Figshare
Canopy-forming plants and algae, in addition to their role as food, can positively affect higher trophic levels by providing protection from predation or stressful abiotic conditions. In the low rocky intertidal zone of the Pacific Northwest, the chiton Katharina tunicata is closely associated with the canopy-forming alga Hedophyllum sessile. In a 27-month field experiment, I used experimental devices to mimic characteristics of the Hedophyllum canopy and monitored the abundance and physiolog...

Barricades and brickwalls – a qualitative study exploring perceptions of medication use and deprescribing in long-term care

Anna Palagyi; Lisa Keay; Jessica Harper; Jan Potter; Richard Lindley (2016)
Publisher: Figshare
Abstract Background The co-administration of multiple drugs (polypharmacy) is the single most common cause of adverse drug events in the older population, and residents of long-term care facilities (LTCFs) are at particularly high risk of medication harm. ‘Deprescribing’ – the withdrawal of an inappropriate medication with goal of managing polypharmacy and improving outcomes – may improve the quality of life of LTCF residents. The RELEASE study sought to explore perceptions of medication use ...