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43366 research data, page 1 of 4337

A molecular genetic toolbox for Yarrowia lipolytica

Abstract Background Yarrowia lipolytica is an ascomycete yeast used in biotechnological research for its abilities to secrete high concentrations of proteins and accumulate lipids. Genetic tools have been made in a variety of backgrounds with varying similarity to a comprehensively sequenced strain. Results We have developed a set of genetic and molecular tools in order to expand capabilities of Y. lipolytica for both biological research and industrial bioengineering applications. In this wor...

Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer

Abstract Background Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood, which has hindered the development of effective targeted therapies capable of improving treatment outcomes in patients with pancreatic cancer. Results We show a central role of Aurora kin...

Avoiding inappropriate urinary catheter use and catheter-associated urinary tract infection (CAUTI): a pre-post control intervention study

Abstract Background Urinary tract infection (UTI) as the most common healthcare-associated infection accounts for up to 36% of all healthcare-associated infections. Catheter-associated urinary tract infection (CAUTI) accounts for up to 80% of these. In many instances indwelling urinary catheter (IDC) insertions may be unjustified or inappropriate, creating potentially avoidable and significant patient distress, embarrassment, discomfort, pain and activity restrictions, together with substanti...

Outcome distribution (1816-2015).

Outcome distribution (1816-2015).

Correlation (R2) of selected free amino acids in the above-ground biomass of plants.

Correlation (R2) of selected free amino acids in the above-ground biomass of plants.

Descriptive statistic (Mean ± SD) of normal and neoplastic cell nuclei with detail on Perimeter, Area and IOD values.

Values of 1000 counted neoplastic A and B cells are also reported. *Asterisk indicates mean values of morphological features significantly different (P