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15969 documents, page 1 of 1597

Stem cells and development : studies on SUFU and LGR5

Hölzl, Maria (2017)
Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT signalling cascades play key roles in a variety of developmental processes where deregulation of these pathways result in a diversity of birth defects. In adult tissue, they are crucial for homeostasis and repair. Therefore, tight regulation of these pathways is of utm...

Dynamics of Descending Inhibition and Neuroendocrine Analgesia with special reference to the Trigeminal region

Feldreich, Anna (2011)
In patients with pain, it is of relevance to use clinical assessments that evaluate the pain modulation. In this thesis, the dynamics of descending inhibition or central sensitization and neuroendocrine analgesia were investigated: in healthy volunteers; in patients with chronic closed lock of the temporomandibular joint (TMJ), before and after discectomy; and finally in patients with possible neuropathic pain, (atypical odontalgia). Pain assessment was made with the eleve...

Genetic study of autosomal dominant progressive external ophthalmoplegia and familial myasthenia gravis : linkage analysis, candidate gene cloning and mutation detection

Li, Fang-Yuan (2001)
Identification of genes responsible for familial human diseases is a major task of medical genetics. In this process, linkage analysis, candidate gene screening and mutation detection are the three major steps (Paper I-VI). The purpose of this study was to elucidate the genetic backgrounds of autosomal dominant progressive external ophthalmoplegia (adPEO) and familial inyasthenia gravis (FMG). The methods applied in this study for linkage analysis and repeat expansion we...

Formation and role of nitric oxide in host defense reactions in the urinary bladder

Morcos, Edward R. I. (2000)
Nitric oxide (NO) is an important biological mediator and cell signaling molecule. It is also involved in several host defense reactions. NO is formed in vivo from L-arginine by the enzyme NO synthase (NOS). However, it can also be formed non-enzymatically from acidified nitrite. The main aim of this thesis was to investigate the formation of NO and its role in host defense in the urinary bladder with focus on intravesical instillation of bacillus Calmette-Guérin (BCG) in th...

Vitamin D insufficiency in cystic fibrosis : prevalence, consequences and intervention

Pincikova, Terezia (2014)
Cystic fibrosis (CF) is the most common life-shortening autosomal recessive disease in Caucasians. The major cause of morbidity and mortality is lung disease, characterized by a vicious circle of infection and inflammation. Management of CF requires a multifaceted approach, where intensive chest physiotherapy is combined with aggressive antibiotic treatment, and tight nutritional follow-up. Vitamin D insufficiency has high prevalence among CF patients worldwide. Vitamin D is cr...

Extremly low frequency magnetic fields and breast cancer

Forssén, Ulla (2003)
Extremely low frequency magnetic fields (ELF EMF) arise around all electrical leaders and equipment that is ran by electricity. In our modem society basically everyone is therefore to some extent exposed to magnetic fields. The possibility that long-term exposure to relatively weak magnetic fields could increase the risk for breast cancer has been discussed during the past decade and is a concern to many people. The underlying hypothesis for a biological mechanism is based o...

Sjuksköterskors erfarenhet av att identifiera tidiga tecken på sepsis hos neonatal barn : en intervjustudie

Färnström, Emma; Udd, Jeanette (2016)
Background: Bacterial systemic infection (sepsis) in the neonatal (0-28 days old) infant is a potentially life threatening condition and requires rapid diagnosis and treatment. Upon arrival at the emergency department the infant is examined by a nurse who makes an assessment of the child’s condition. Triaging a neonatal infant is a demanding task since the infant’s clinical status can rapidly change. It is therefore desirable that the nurse who conducts the triage has considerable experience....

Technology use in everyday activities among older adults with mild cognitive impairment : a study of changes over time and views on technology as support

Hedman, Annicka (2015)
The overall aim of this thesis was to provide new knowledge of everyday technology (ET) use and functioning over time, as perceived by persons with cognitive decline due to mild cognitive impairment (MCI). A secondary aim was to increase knowledge about their views on technology as part of and as potential support in everyday life. The first three studies build on longitudinal instrument-based data from a cohort of 37 older adults with MCI at inclusion. The fourth study included six pa...

RC4 Review

Salvagno, Anthony (2015)

Acute lung injury : incidence and predictors of outcome with special reference to inhaled nitric oxide

Luhr, Owe (1999)
This work started out as a critical examination of the initial clinical experiences with inhalation of nitric oxide (INO) to patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in Scandinavia 1991-1994. During this examination, we found that epidemiological data and prognostic factors were lacking in Scandinavia for these patient groups, making it difficult to evaluate new therapies. In addition, no studies addressing genotoxicity of INO in h...