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13563 documents, page 1 of 1357

Genomic and non-genomic effects of a new sodium-sensing network in renal and lung epithelia

Eneling, Kristina (2012)
Sodium and water homeostasis is crucial for cell function, survival and health of the individual. The kidney is responsible for sodium regulation in the body, balancing sodium secretion and reabsorption, and thereby also regulating the blood pressure, primarily via the Na+, K -ATPase. The Na+, K+ -ATPase is situated in the basolateral part of the polarized cell membrane and drives the vectorial transport of Na+ over the epithelium and water follows the ionic gradient. Vect...

Gene regulation, intracellular signaling and membrane traffic : Studies in primary human skeletal muscle cultures

Al-Khalili, Lubna (2004)
Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. In this thesis primary human skeletal muscle cell culture (HSMC) has been used to investigate gene regulation, cellular signaling and membrane traffic. The expression of several myogenic and insulin responsive proteins, as we...

ER subtype-specific regulation of estrogen signaling

Cai, Wen (2011)
The estrogen receptor (ER) isoforms, ERα and ERβ, mediate the physiological functions of the female hormone estrogen. They share high degree of similarity but also show significant differences in many aspects, such as cell and tissue distribution. The activities of ER are tightly regulated by different factors at multiple levels. The biological action of estrogen is the result of a balance between ERα and ERβ activities; and disruption of this balance leads to various health di...

Hypospadias and increased risk for neurodevelopmental disorders

Butwicka, Agnieszka; Lichtenstein, Paul; Landén, Mikael; Nordenvall, Anna; Nordenström, Anna; Nordenskjöld, Agneta; Frisén, Louise (2014)
BACKGROUND: Hypospadias (aberrant opening of the urethra on the underside of the penis) occurs in 1 per 300 newborn boys. It has been previously unknown whether this common malformation is associated with increased psychiatric morbidity later in life. Studies of individuals with hypospadias also provide an opportunity to examine whether difference in androgen signaling is related to neurodevelopmental disorders. To elucidate the mechanisms behind ...

Time Elapsed from Onset of Symptoms to Diagnosis of Gonorrhoea in Swedish Patients, 1999-2009

Kader, Manzur; Sharma, Arpana; Velicko, Inga; Ahmad, Meraj (2014)
Background: Gonococcal infection remains an important public health problem worldwide. The incidence of reported gonorrhoea cases in Sweden raised by 32%, from 5.9 to 7.8 cases per 100,000 in 2001 to 2008.The aim of this study is to estimate the lag time or time elapsed between onset of symptoms and diagnosis of gonorrhoea, and to identify the factors associated with diagnostic delay in a sample of reported gonorrhoea cases in Sweden. Methods: A retrospective cohort study was conducted ...

Autoantigenic properties of the U1-70K protein

Welin Henriksson, Elisabet (1998)
Autoantigenic properties of the U1-70K protein Elisabet Welin Henriksson Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, S-171 77 Stockholm, Sweden Patients with the autoimmune diseases systemic lupus erythematosus and mixed connectivetissue disease produce autoantibodies directed towards specific groups of cellularconstituents in their own body. Two of the targeted antigens are denoted Sm and RNP,and consist of distinct coll...

Visual linearization of image data for the display of digital intraoral radiographs

Li, Gang (2004)
Digital intraoral radiography has developed rapidly during the past decade. The most important advantage of this technique is that it breaks the fixed relationship between exposure and density that is inherent in film radiography. Thus, processing of digital intraoral radiographs after image capturing has become possible. A great number of digital image processing algorithms have been introduced. However, these algorithms do not directly consider the exponential attenuation ...

Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone R)

Thapar, Mita M (2004)
Malarone® is a fixed dose combination of atovaquone and proguanil and is mainly used for prophylaxis against P. falciparum malaria as an alternative to Lariamo® or chloroquine+proguanil. Knowledge of pharmacokinetics (PK) and pharmacodynamics (PD) is required to describe, quantify, and predict drug effects in humans in order to achieve desired therapeutic activity with minimum side effects. PK and PD of Malarone® were therefore studied with the aim to contribute to a better ...

The Wnt pathway in ventral midbrain dopaminergic differentiation

Ribeiro, Diogo (2011)
Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. Cell-replacement therapy (CRT), where DA neurons and/or precursors are grafted into the striatum in order to restore the lost striatal DA...

Studies of the physiological status of bacteria used for environmental applications

Maraha, Ninwe (2004)
Today, it is difficult to study the physiological status of inoculants in complex environments, such as soil. In this thesis, we describe the combined use of marker genes and viability stains to determine the physiological status of the bacterial cells in pure cultures and in soil. In the experiments, cells previously tagged with gfp and luxAB or luc marker genes (encoding the green fluorescent protein and bacterial or eukaryotic luciferase, respectively) were used. Viabili...