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11 documents, page 1 of 2

Role and Place of Hyperbaric Oxygenation in Hepatic Failure

Objective: to define the role and place of hyperbaric oxygenation (HBO) in the treatment and prevention of liver cell failure. Material and methods. The results of the author’s own studies and the data available in the literature on the impact of HBO on the functional state of the liver and the whole organism in liver cell failure were analyzed. Results: The therapeutic and preventive effects of HBO during therapy for liver cell failure were due to the ability of hyperbaric oxygen to re...

Impact of Hyperbaric Oxygenation on the Phagocytosis-Stimulating Function of the Operated Liver

Objective: to study the ability of hyperbaric oxygenation (HBO) to eliminate impaired phagocytosis-stimulating hepatic function caused by hepatectomy (HE). Material and methods. Experiments were conducted on 82 outbred female albino rats exposed to HE (15—20% of the organ mass) and HBO at 3 ata for 50 min once daily three times within the first three days after surgery. The capacities of neutrophils and monocytes of arterial (aorta) and venous (portal vein, hepatic veins) blood to ingest and ...

Nitrogen Metabolism During Hepatectomy and Hyperbaric Oxygenation: Experimental Study

Objective: to examine nitrogen metabolism in the organs of the portal system during liver resection (LR) and hyperbaric oxygenation (HBO).Material and methods: Experiments were conducted on 65 female albino rats. LR was made under ether anesthesia, by removing a portion of the left hepatic lobe with an electric knife, which amounted to 15—20% of the organ’s mass. HBO was performed using medical oxygen at 3 ata for 50 min once daily within the first three days after LR. Lung tissue, gastrointe...

Excretion of Ammonia and Urea by the Kidneys after Liver Resection and Hyperbaric Oxygenation

The objective of the study is to examine the impact of hyperbaric oxygenation (HBO) on ammonia excretion by kidneys in case of hepatectomy.Materials and methods. Experiments were conducted on 138 mature (female) rats. HBO was conducted at 3 atm during 50 minutes (three times), one session daily after hepatectomy (15-20% of the organ weight). Test objects were kidneys, blood (aorta, v.renalis), urine. The concentration of ammonia, glutamine, and urea were identified.Results. By eliminating pos...

The Kinetics of Urea in the Body after Liver Resection in the Experiment

Purpose. To study urea kinetics in the body after liver resection in the experiment.Material and Methods. Experiments were carried out on 45 white female rats weighing between 180 g and 220 g. Liver resection (LR) was performed under ester anesthesia, wherein 15—20% of the organ weight was removed. Urea content was studied in biological fluids (arterial blood, venous — v.porta, v.hepatica, v.renalis — blood, choledochal bile, urine), and tissues of visceral organs (the thyroid gland, lungs, h...

IMPACT OF HYPERBARIC OXYGENATION ON RENAL AMMONIA EXCRETION DURING EXPERIMENTAL LIVER RESECTION

Objective: to study the impact of hyperbaric oxygenation (HBO) on renal ammonia excretion during liver resection (LR). Material and methods. Experiments were carried out on 138 pubescent rats (females). Three HBO sessions were performed at 3 ATA lasting 50 min once daily after LR (15—20% of the liver weight). The kidney, blood (aorta, v. renalis), and urine were examined. The levels of ammonia, glutamine, and urea were measured. Results. By eliminating postoperative arterial hyperammonemia, H...

Impact of Hyperbaric Oxygenation on Blood Anticolibacillary Activity in Hepatectomy

Objective: to study the anticolibacillary activity of arterial (aorta) and venous (portal vein, hepatic veins) blood during hepatectomy and hyperbaric oxygenation (HBO).Material and methods: Experiments were conducted on 40 non-inbred female albino rats exposed to hepatic resection (15—20% of organ mass) and HBO at 3 ata for 50 min once daily within the first three days after surgery. The bactericidal action of blood serum against E.coli and the capacity of neutrophils and monocytes to absorb...

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock

Purpose. To study glutamate metabolism characteristics in phylogenetically different parts of the mammalian brain in experimentally induced hemorrhagic shock (HS) in cats.Material and methods. Experiments were performed on 76 cats. HS was induced by intermittent bloodletting from femoral artery at a rate of 10ml/kg•10 minutes, with the average volume of 24±0.8 ml/kg. The bloodletting was discontinued after arterial pressure (BP) drop to 60.0±1.5 mmHg. We studied ammonia, glutamate (Gt), and α...

Impact of Hyperbaric Oxygenation on Blood Antistaphylococcal Activity During Liver Resection

Objective: to study the impact of liver resection (LR) and a hyperbaric oxygenation (HBO) session and their combination on blood antistaphylococcal activity. Material and methods. Experiments were carried out on 77 outbred albino rats (females) exposed to LR (15—20% of the liver weight) and HBO at 3 ata as a 50-min session once daily, which was used in the operated rats in the first 3 days after LR. Serum bactericidal activity against opportunistic (No. 1726) and pathogenic (No. 209) S.aureus...

Impact of Hyperbaric Oxygenation on Ammonia Kinetics in Hepatic Failure (an Experimental Study)

Objective: to study ammonia kinetics in hepatic failure and in the course use of hyperbaric oxygenation (HBO) sessions. Material and methods. Experiments were carried out on 210 female albino rats. HBO was thrice conducted at 3 ata for 50 min once daily after hepatectomy (HE, 15—20% of the liver mass). Ammonium levels were determined in the visceral organs and blood from the following vessels: the aorta, v. porta, v. hepatica, v. renalis. Results. By preventing ammonia from entering the centr...