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111 documents, page 1 of 12

Ethanol binding sites on proteins

Khrustalev, V. V.; Khrustaleva, T. A.; Lelevich, S. V. (2017)
Ethanol Hydrogen bonds Binding site Beta strand Alpha helix 3/10 helix Secondary structure This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are underrepresented around them. Residues of Ala and Pro ar...

Unrecorded Alcohol Consumption: Quantitative Methods of Estimation

Razvodovsky, Y. E. (2010)
unrecorded alcohol; methods of estimation In this paper we focused on methods of estimation of unrecorded alcohol consumption level. Present methods of estimation of unrevorded alcohol consumption allow only approximate estimation of unrecorded alcohol consumption level. Tacking into consideration the extreme importance of such kind of data, further investigation is necessary to improve the reliability of methods estimation of unrecorded alcohol consumption.

Ultrastructural Changes in Cerebral Histaminergic Neurons on Exposure to Alcohol

Zimatkin, S. M.; Fedina, E. M. (2015)
brain, histaminergic neurons, ultrastructure, alcohol The aim of the present work was to analyze the ultrastructural changes developing :n cerebral histaminergic neurons in 24 mongrel white male rats after administration of ethanol in acute experimental conditions (single i.p. doses of 1 and 4 g kg), in subacute conditions (sole source of drinking fluid. 4 g kg. for" days), or chronic conditions (2-3 g kg day for 6 months). Administration of alcohol led to the development of a variety of u...

Ocena rozpowszechnienia uzywania substancji psychoaktywnych wsrod ludnosci na Biatorusi

Lelevich, V.; Lelevich, S. (2014)
psychoactive substances, drug abusers, Narcological Register, population, Belarus Aim. To evaluate the prevalence of psychoactive substance abuse among the population of Belarus. Material and methods. The data on registered drug abusers, who were recorded in the Narcological Register in health care institutions between 1998 and 201 2, were analyzed. Results. During that period the significant growth (by 3.5 times) in the number of recorded drug abusers was observed, mainly of those w...

CXCR4+ and CCR5+ expression on blood lymphocytes and its changes in AIDS development in HIV/HCV coinfected patients

Matsiyeuskaya, N. V.; Tsyrkunov, V. M.; Hancharou, A. Y. (2012)
HIV, HCV, coinfection, immune response, chemokine receptors, CCR5, CXCR4. Purpose: To measure the CCR5+ and CXCR4+ expression on blood lymphocytes, its changes in AIDS development, and correlation of CCR5+ and CXCR4+ expression with a number of T-cells, T-helpers, cytotoxic T-cells, activated T-cells (CD3+ HLA-DR+), T-regs cells, natural killer (NK)-cells, B cells, in order to determine the type of immune response activation in HIV/HCV coinfected patients. Materials and methods: The ...

Suicides in Russia and Belarus: a comparative analysis of trends

Razvodovsky, Y. E (2015)
Alcohol sales; suicide rates; ARIMA time series analysis; Russia; Belarus; 1970-2014. Background; The Slavic countries of the former Soviet Union (fSU) Russia and Belarus retain one of the highest suicide rates in the world, despite a gradual decline over the past decade. Aim: The present study aims to analyze whether population drinking is able to explain the dramatic fluctuations in suicide mortality in Russia and Belarus from the late Soviet to post-Soviet period. Method: Trends i...

Blood Oxygen Transport and Prooxidant-Antioxidant Balance in Rats under Hypothermia and Rewarming Combined with a Modification of L-arginine-NO Pathway

Zinchuk, V.; . Hlutkin, S (2015)
hypothermia, rewarming, hemoglobin-oxygen affinity, nitric oxide Introduction: The study ofprocesses and functional regulation in body under the changed (including the lower) body temperature is the important medical problem Increase of body resistance to low environmental temperature is especially important for the patient reanimation after the cold exposure, and the assessment of mechanisms creating the tissue oxygen flux may help the development of ways for reanimation of a cooled body....

Genesial health of teenage girls with inflammatory diseases of generative organs between 1984-1994 in Grodno area

Naumov, I. A.; Tishchenko, E. M.; Aleksandrovich, A. S. (2010)
genesial health, inflammatory diseases of generative organs Introduction. The research urgency is defined by absence of studies and the conforming analytical assessments for working out expert approaches and methods on conservation and improvement of genesial health (GH) in the given contingent of women of reproductive age. Aim. To carry out retrospective research of GH status in women aged 15-17 years with inflammatory diseases of generative organs (IDGO). Material and methods. The ...

Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic strokes

Semyachkina-Glushkovskaya, O.; Sindeeva, O.; Abdurashitov, A; Sindсev, S.; Zinchenko, E.; Gekaluk, A.; Ulanova, M.; Mohanad, K; Yankovskaya, L. (2015)
Stroke; age differences; cerebral blood flow; brain blood barrier. Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive deficits. There are important differences in the factors, inical events and outcomes associated with the stroke in infants and adults. However, anisms underlying age differences in the stroke development remain largely unknown. Therefore, treatment guidelines for neonatal stroke must ext...

Cardiac fibrosis in patients with atrial fibrillation: Mechanisms and clinical implications

Dzeshka, M. S.; Lip, G. Y. H.; Snezhitskiy, V. A.; Shantsila, E. (2015)
atrial fibrillation, heart failure, cardiac fibrosis Atrial fibrillation (AF) is associated with structural, electrical and contractile remodeling of the atria. Development and progression of atrial fibrosis is the hallmark of structural remodeling in AF and is considered to be substrate for AF perpetuation. In contrast, experimental and clinical data on impact of ventricular fibrotic processes in pathogenesis of AF and its complications are controversial. Ventricular fibrosis appears to c...