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110 documents, page 1 of 11

Ethanol binding sites on proteins

Khrustalev, V. V.; Khrustaleva, T. A.; Lelevich, S. V. (2017)
Ethanol Hydrogen bonds Binding site Beta strand Alpha helix 3/10 helix Secondary structure This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are underrepresented around them. Residues of Ala and Pro ar...

Unrecorded Alcohol Consumption: Quantitative Methods of Estimation

Razvodovsky, Y. E. (2010)
unrecorded alcohol; methods of estimation In this paper we focused on methods of estimation of unrecorded alcohol consumption level. Present methods of estimation of unrevorded alcohol consumption allow only approximate estimation of unrecorded alcohol consumption level. Tacking into consideration the extreme importance of such kind of data, further investigation is necessary to improve the reliability of methods estimation of unrecorded alcohol consumption.

Edoxaban for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation

Dzeshka, M. S.; Lip, G. Y. (2015)
Projects: HRZZ | Advanced 3D Perception for Mobile Robot Manipulators (3155)
edoxaban, warfarin, oral anticoagulation, atrial fibrillation, efficacy, safety. Introduction Oral anticoagulation is central to the management of patients with atrial fibrillation (AF) and at least one additional stroke risk factor. For decades, the vitamin K antagonists (e.g. warfarin) remained the only oral anticoagulant available for stroke prevention in AF. The non-vitamin K oral anticoagulants (NOACs) are now available, and these drugs include the direct thrombin inhibitors and facto...

Non-vitamin K Oral Anticoagulants in atrial fibrillation: where are we now?

Dzeshka, M. S.; Lip, G. Y. (2015)
atrial fibrillation, non-vitamin K oral anticoagulants, dabigatran, rivaroxaban, apixaban, edoxaban, warfarin Atrial fibrillation (AF) confers increased risk of stroke and other thromboembolic events, and oral anticoagulation therefore is the essential part of AF management to reduce the risk of this complication. Until recently, the vitamin K antagonists (VKAs, e.g. warfarin) were the only oral anticoagulants available, acting by decreased synthesis of vitamin K-dependent coagulation fact...

Patients with atrial fibrillation undergoing percutaneous coronary intervention. Current concepts and concerns: part II

Dzeshka, M. S.; Brown, R. A.; Lip, G. Y. H (2015)
antithrombotic prophylaxis, atrial fibrillation, coronary artery disease, percutaneous coronary intervention Atrial fibrillation (AF) and coronary artery disease (CAD) often present concomitantly. Given the increased risk of thrombotic complications with either of them but different pathogenesis of clot formation, combined antithrombotic therapy is necessary in patients developing acute coronary syndrome and/or undergoing percutaneous coronary intervention (PCI). Different antithrombotic r...

Test of modified ultra-high molecular weight polyethylene for prosthetic repair of the ossicular chain

Khorov, O; Struk, V.; Novasialetski, U. (2013)
ultra-high molecular weight polyethylene, high density, ossiculoplasty, ossicular chain prosthesis Background: Our aim was to evaluate the effect of implantation of a surface-modified ultra-high molecular weight polyethylene (UHMWPE) of high density into a rabbit ear s bulla in terms of biochemical and immunological blood parameters and middle ear tissue morphology. Material and Methods: Exactly 35 rabbits were used, divided into 3 groups. In the lsl group the ears were implanted with a...

Some integrated laboratory peritoneal fluid indicators in inflammatory pelvic disease diagnostics

Kostiahin, A. E.; Kazhyna, M. V.; Doroshenko, E. M.; ĐšosenIuk, N. K.; Gonchar, E. V.; Gurin, A. L.; Ghigareva, L. F.; Kuchuk, D. O. (2010)
cul-de-sac, peritoneal liquid, exudate, transsudate, acute inflammatory pelvic disease Laboratory criteria of differential diagnostics of pelvic inflammatory disease are established. We provide the retrospective analysis of the medical documentation in patients treated in gynecologic departments. The analysis of integrated laboratory criteria is carried out in 35 cases of females at the age from 18 till 45 years with diagnosis of chronic and acute pelvic disease, ovarium cysts, ovarian cys...

The teenager as a medical patient: The influence of social factors on the health care activity of teenagers in the field of reproductive health

Surmach, M. (2012)
teenagers, medical activity, social factors, reproductive health Background: Teenagers tend to abandon the programs of preventive and therapeutic medical care established for them in infancy by their pediatricians and parents. Purpose: To assess the influence of social factors on the health behaviours of Belarusian teenagers in the field of reproductive health. Material and methods: We analyzed the medical activity of Belarusian teenagers ages 15 to 18 during (March through June 201...

Fraction of Tuberculosis Mortality Attributable to Alcohol in Russia

Razvodovsky, Y. E (2015)
Tuberculosis; Mortality; Alcohol sales; ARIMA time series analysis; Russia; 1980-2010 Background: The Russian Federation has the 11 highest burden of tuberculosis (TB) in the world and third-highest burden of multidrug resistant TB. Alcohol continues to play a crucial role in the Russian TB mortality crisis. Objectives: The aim of the present study was to estimate the TB mortality attributable to alcohol abuse in Russia using aggregate-level data of TB mortality and the level of alcohol sa...

Current alcohol policy in the Republic of Belarus

Razvodovsky, Y. E. (2012)
An analysis of the state alcohol policy is presented. The dynamics of total alcohol consumption, unregistered alcohol consumption and alcohol sales in Belarus were evaluated for the period 1980-2009. It was shown that the implementation of measures within the framework of the state alcohol policy resulted in a significant reduction in unregistered alcohol consumption and a slight reduction in total alcohol consumption.