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26416 documents, page 1 of 2642

A sedimentação fluvial cenozóica na região do Entre-Douro-e-Minho (NW de Portugal)

Na região foram identificados cinco ciclos de glipto/sedimentogénese fluvial cenozóicos, de importância regional, decorridos no Pliocénico superior (Placenciano) e Quaternário. A cada um destes ciclos de glipto/sedimentogénese correspondeu escavação de novo talvegue no substrato seguida de colmatação do paleovale. Esta interpretação baseia-se num conjunto de informações que têm sido obtidas através do estudo dos sedimentos, das paleoalterações associadas e das observações de ca...

High-level expression of Aspergillus niger β-galactosidase in Ashbya gossypii

Ashbya gossypii has been recently considered as a host for the expression of recombinant proteins. The production levels achieved thus far were similar to those obtained with Saccharomyces cerevisiae for the same proteins. Here, the β-galactosidase from Aspergillus niger was successfully expressed and secreted by A. gossypii from 2-micron plasmids carrying the native signal sequence at higher levels than those secreted by S. cerevisiae laboratorial strains. Four different constitutive promote...

Hyperbolic Conservation Laws on Manifolds: Total Variation Estimates and the Finite Volume Method

This paper investigates some properties of entropy solutions of hyperbolic conservation laws on a Riemannian manifold. First, we generalize the Total Variation Diminishing (TVD) property to manifolds, by deriving conditions on the flux of the conservation law and a given vector field ensuring that the total variation of the solution along the integral curves of the vector field is non-increasing in time. Our results are next specialized to the important case of a flow on the 2-sphere, and exa...

A novel and efficient route for the syntheses of hydroxylated 2,3-diarylxanthones

A novel, efficient and general route for the synthesis of hy-droxylated 2,3-diarylxanthones is described. 3-Bromo-2-styrylchromones, the key intermediate of this synthesis, is obtained by a Baker-Venkataraman rearrangement of appropriate 2’-cinnamoyloxyacetophenones, followed by a one-pot reaction with phenyltrimethylammonium tribromide. The Heck reaction of these bromochromones with substituted styrenes gives methoxylated 2,3-diarylxanthones. The cleavage of the methyl groups with BBr3 gives...

Collecting system percutaneous access using real-time tracking sensors: first pig model in vivo experience

PURPOSE: Precise needle puncture of the renal collecting system is a challenging and essential step for successful percutaneous nephrolithotomy (PCNL). This works aims to evaluate the efficiency of a new real-time electromagnetic tracking (EMT) system for in vivo kidney puncture. MATERIALS AND METHODS: Six anesthetized female pigs underwent ureterorenoscopies in order to place a catheter with an EMT sensor into the desired puncture site and to ascertain the success of puncture. Subse...

Oxidative Stress and Drugs of Abuse: An Update

Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, followed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cellular macromolecules, and may culminate in cell dysfunction and death. In this revi...

When the Eyes No Longer Lead: Familiarity and Length Effects on Eye-Voice Span

During oral reading, the eyes tend to be ahead of the voice (eye-voice span, EVS). It has been hypothesized that the extent to which this happens depends on the automaticity of reading processes, namely on the speed of print-to-sound conversion. We tested whether EVS is affected by another automaticity component – immunity from interference. To that end, we manipulated word familiarity (high-frequency, low-frequency, and pseudowords, PW) and word length as proxies of immunity from interferenc...

Recensão: Claire Bishop, "Radical Museology: or What’s ‘Contemporary’ In Museums of Contemporary Art?"

Recensão de: Claire Bishop, "Radical Museology: or What’s ‘Contemporary’ In Museums of Contemporary Art?", Londres: Koenig Books, 2013 Fundação para a Ciência e a Tecnologia (FCT), Fundação Millennium bcp

Flow of red blood cells in microchannel networks: in vitro studies

Human blood is a multiphase biofluid primarily composed by the deformable red blood cells (RBCs) suspended in plasma. Because the complex structure of RBCs, blood exhibits unique flow characteristics on micro-scale level, due to their complex biochemical mechanisms and their response to both shear and extensional flow, which influence the rheological properties and flow behaviour of blood [1,2]. In the past years in vitro blood studies have been extensively performed and some important phy...