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2 documents, page 1 of 1

Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method

Barns, Sarah; Balanant, Marie Anne; Sauret, Emilie; Flower, Robert; Saha, Suvash; Gu, YuanTong (2017)
Projects: ARC | Linkage Projects - Grant ID: LP150100737 (LP150100737), ARC | Discovery Projects - Grant ID: DP150100828 (DP150100828)
Background Red blood cells (RBCs) deform significantly and repeatedly when passing through narrow capillaries and delivering dioxygen throughout the body. Deformability of RBCs is a key characteristic, largely governed by the mechanical properties of the cell membrane. This study investigated RBC mechanical properties using atomic force microscopy (AFM) with the aim to develop a coarse-grained particle method model to study for the first time RBC indentation in both 2D and 3D. This new model ...

SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries

Background Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree particle approach to model and predict the motion and deformation of three-dimensional RBCs in capillaries...