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1543462 documents, page 1 of 154347

Hybrid Design Thinking in a Consummate Marriage of People and Technology

In this paper we take a hybrid design tool approach to integrate existing and new advances in HCI, problem-solving, decision-making, mind-mapping, universal access in conjunction with multi-disciplinary and cross-domain areas based on holistic and interactive systems. Our hybrid approach constitutes on the exploration and experimental tradition where we rely on an assortment of heuristics and operate mostly in a highly unpredictable, probabilistic manner across boundaries and often un-structu...

Optimization for high fidelity imaging with aperture array telescopes

ASTRON, het Nederlandse instituut voor radiosterrenkunde, heeft LOFAR ontwikkeld en gerealiseerd; een instrument met een onconventioneel ontwerp: fasegestuurde antennes. Dit ontwerp maakt het een stuk goedkoper en sneller om een grote telescoop op te bouwen. Ook zijn de wetenschappelijke toepassingen legio. Het mechanische deel van LOFAR heeft een heel eenvoudig ontwerp, het bestaat uit duizenden simpele dipoolantennes. Dit moeten we bekopen in de data-analyse. Het onconventionele ontwerp van...

Dirigentas de campamento y actividad mediática: Más allá de internet

markdownabstract__RESUMEN__ El debate en torno al carácter activo de las audiencias contemporáneas tiende a centrarse en las nuevas tecnologías de comunicación y en las posibilidades de producción de contenido que ellas ofrecen. Este artículo propone, en cambio, atender al carácter político de ciertas actividades mediáticas y a factores no-tecnológicos. Específicamente, identificamos la llamada cultura promocional como un impulso importante para influir —y no directamente producir— los conten...

Two-sided online markets for electric vehicle charging

With the growing popularity of electric vehicles (EVs), the number of public charging stations is increasing rapidly, allowing drivers to charge their cars while parked away from home or en-route to their destination. However, as a full charge can take a significant amount of time, drivers may face queues and uncertainty over availability of charging facilities at different stations and times. In this paper, we address this problem by proposing a novel, two-sided market for advance reservatio...

Genomewide association study of cocaine dependence and related traits: FAM53B identified as a risk gene

We report a GWAS for cocaine dependence (CD) in three sets of African- and European-American subjects (AAs and EAs, respectively), to identify pathways, genes, and alleles important in CD risk. The discovery GWAS dataset (n=5,697 subjects) was genotyped using the Illumina OmniQuad microarray (890,000 analyzed SNPs). Additional genotypes were imputed based on the 1000 Genomes reference panel. Top-ranked findings were evaluated by incorporating information from publicly available GWAS data from...

臨床看護師の倫理観と疲労との関係 道徳的発達段階・倫理的感受性と蓄積的疲労との比較

今日の臨床看護現場では2003年の診療報酬改定に伴う包括払い制度の導入により入退院が増加して看護師は常に多数の重症患者の医療処置と看護を強制されることになり、過重な労働から蓄積的疲労を高めている。看護師の疲労が強ければ強いほど患者を気遣う余裕がなくなり、看護師の倫理観の低下に繋がることが予測される。しかし、看護師の倫理観と疲労との関係を調査した報告は見られない。そこで、本研究では道徳的発達段階・倫理的感受性と蓄積的疲労との関係について総合病院に勤務する看護師894名を対象としてアンケート調査を実施し、607名から全問回答したアンケートを回収し(有効回収率:67.9%)、その内容を解析することにより看護師の倫理観と疲労との関係を検討した。道徳的発達段階を調べるには葛藤価値定義づけテスト(Defining Issues Test:DIT)日本語版を用いた。DITは道徳的発達理論に基づいた倫理水準の測定法であり、DIT得点が高いほど道徳的発達段階が高いとされている。倫理的感受性を調べるには道徳的感受性テスト(Moral Sensitivity Test:MST)日本語版を用いた。MST...

Dieta e estratégia alimentar de Characidium rachovii (Characiformes, Crenuchidae) em riachos de planície costeira do sul do Brasil

Characidium rachovii (Regan, 1913) é uma espécie frequente em riachos da planície costeira do estado do Rio Grande do Sul, sul do Brasil. Entretanto, seu nicho trófico é ainda desconhecido. O presente trabalho teve como objetivos: (i) descrever a dieta de C. rachovii de três riachos costeiros do RS; (ii) avaliar a influência de um ecótono (mar-riacho) na dieta, comparando dois locais, um próximo do mar e outro distante, e (iii) avaliar o efeito do número de indivíduos analisados na riqueza da...

T-cell modulatory properties of CD5 and its role in antitumor immune responses

The destruction of tumor cells by the immune system is under the control of positive and negative receptors that tightly regulate T-cell effector functions. The T-cell receptor (TCR) inhibitory molecule CD5 critically contributes to the regulation of antitumor immune responses. Indeed, the modulation of CD5 within the tumor microenvironment corresponds to a strategy adopted by tumor-specific cytotoxic T lymphocytes (CTLs) to optimize their cytotoxic and cytokine secretion functions. In this r...