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Journal of Amino Acids
58 Publications
collected from a compatible aggregator


  • Bioactive Peptides in Cancer: Therapeutic Use and Delivery Strategies

    Stiuso, Paola; Caraglia, Michele; De Rosa, Giuseppe; Giordano, Antonio (2013)

    Acute Effects of an Energy Drink on Myocardial Function Assessed by Conventional Echo-Doppler Analysis and by Speckle Tracking Echocardiography on Young Healthy Subjects

    Menci, Daniele; Righini, Francesca Maria; Cameli, Matteo; Lisi, Matteo; Benincasa, Susanna; Focardi, Marta; Mondillo, Sergio (2013)
    Purpose. Previous studies have underlined the effects of the energy drinks containing caffeine end taurine on the cardiovascular system. The aim of this study was to determine acute changes on echocardiographic parameters assessed by conventional echo-Doppler analysis and by speckle tracking echocardiography after the consumption of an energy drink in a young healthy population. Methods. measurement of blood pressure, electrocardiographic, and echocardiographic examination were performed on 3...

    (R)-α-Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids

    Sadiq, Amina; Sewald, Norbert (2013)
    The ready accessibility of (R)-α-aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids. A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of (R)-pipecolic acid is described which utilizes (R)-α-aminoadipic acid as the enantiomerically pure starting material. Moreover, the synthesis of azido and tria...

    The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study

    du Plooy, Christine Susara; Mels, Catharina Martha Cornelia; Huisman, Hugo Willem; Kruger, Ruan (2015)
    Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n = 99; women: n = 95) and 197 white (men: n = 99; women: n = 98) South Africans. Serum ET-1 levels were measured as well as markers of arteri...

    Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

    Vernieri, Ermelinda; Gomez-Monterrey, Isabel; Milite, Ciro; Grieco, Paolo; Musella, Simona; Bertamino, Alessia; Scognamiglio, Ilaria; Alcaro, Stefano; Artese, Anna; Ortuso, Francesco; Novellino, Ettore; Sala, Marina; Campiglia, Pietro (2013)
    Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostaglandins, which are mediators of inflammation. It exists mainly in two isoforms COX-1 and COX-2. The conventional nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects because they inhibit both isoforms. Recent data demonstrate that the overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in additi...
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