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Institutional Repository for Molecular Medicine (MDC)
Publication Repository
2326 Publications


  • Roquin binding to target mRNAs involves a winged helix-turn-helix motif

    Schuetz, A.; Murakawa, Y.; Rosenbaum, E.; Landthaler, M.; Heinemann, U. (2014)
    Roquin proteins mediate mRNA deadenylation by recognizing a conserved class of stem-loop RNA degradation motifs via their Roquin domain. Here we present the crystal structure of a Roquin domain, revealing a mostly helical protein fold bearing a winged helix-turn-helix motif. By combining structural, biochemical and mutation analyses, we gain insight into the mode of RNA binding. We show that the winged helix-turn-helix motif is involved in the binding of constitutive decay elements-containing...

    Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke

    Hoffmann, C.J.; Harms, U.; Rex, A.; Szulzewsky, F.; Wolf, S.A.; Grittner, U.; Lättig-Tünnemann, G.; Sendtner, M.; Kettenmann, H.; Dirnagl, U.; Endres, M.; Harms, C. (2015)
    BACKGROUND: Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS: We generated a tamoxifen-inducible and endothelial-specific Stat3 knockout mouse model by crossbreeding Stat3(floxed/KO) and Tie2-Cre(ERT2) mice. Cerebral ischemia was induced by 30 m...

    The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells

    Patzke, C.; Max, K.E.; Behlke, J.; Schreiber, J.; Schmidt, H.; Dorner, A.A.; Kroeger, S.; Henning, M.; Otto, A.; Heinemann, U.; Rathjen, F.G. (2010)
    The coxsackievirus-adenovirus receptor (CAR) is a member of the Ig superfamily strongly expressed in the developing nervous system. Our histological investigations during development reveal an initial uniform distribution of CAR on all neural cells with a concentration on membranes that face the margins of the nervous system (e.g., the basal laminae and the ventricular side). At more advanced stages, CAR becomes downregulated and restricted to specific regions including areas rich in axonal a...

    Corollary discharge inhibition of ascending auditory neurons in the stridulating cricket

    Poulet, J.F.A.; Hedwig, B. (2003)
    Acoustically communicating animals are able to process external acoustic stimuli despite generating intense sounds during vocalization. We have examined how the crickets' ascending auditory pathway copes with self-generated, intense auditory signals (chirps) during singing (stridulation). We made intracellular recordings from two identified ascending auditory interneurons, ascending neuron 1 (AN1) and ascending neuron 2 (AN2), during pharmacologically elicited sonorous (two-winged), silent (o...

    Assessing the bioenergetic profile of human pluripotent stem cells

    Pfiffer, V.; Prigione, A. (2015)
    Assessing the bioenergetics of human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provides considerable insight into their mitochondrial functions and cellular properties. This might allow exposing potential energetic defects caused by mitochondrial diseases. However, certain challenges have to be met due to unique growth conditions in highly specialized and costly culture media. Here, we describe a method that facilitates t...
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