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Institutional Repository for Molecular Medicine (MDC)
Publication Repository
2319 Publications


  • CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation

    Keller, J.; Ellieva, A.; Ma, D.K.; Ju, J.; Nehk, E.; Konkel, A.; Falck, J.R.; Schunck, W.H.; Menzel, R. (2014)
    A specific behavioural response of Caenorhabditis elegans, the rapid increase of locomotion in response to anoxia/reoxygenation called the O2-ON response, has been used to model key aspects of ischaemia/reperfusion injury. A genetic suppressor screen demonstrated a direct causal role of CYP (cytochrome P450)-13A12 in this response and suggested that CYP-eicosanoids, which in mammals influence the contractility of cardiomyocytes and vascular smooth muscle cells, might function in C. elegans as...

    CCN1 mutation is associated with atrial septal defect

    Perrot, A.; Schmitt, K.R.; Roth, E.M.; Stiller, B.; Posch, M.G.; Browne, E.N.L.; Timmann, C.; Horstmann, R.D.; Berger, F.; Ozcelik, C. (2015)
    The genetic basis of congenital heart disease remains unknown in most of the cases. Recently, a novel mouse model shed new light on the role of CCN1/CYR61, a matricellular regulatory factor, in cardiac morphogenesis. In a candidate gene approach, we analyzed a cohort of 143 patients with atrial septal defects (ASD) by sequencing the coding exons of CCN1. In addition to three frequent polymorphisms, we identified an extremely rare novel heterozygous missense mutation (c.139C > T; p.R47W) in on...

    Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

    Lewin, G.R.; Ritter, A.M.; Mendell, L.M. (1993)
    Recently, we have shown that the interaction between NGF and sensory neurons in early postnatal periods is restricted to nociceptive afferents (Ritter et al., 1991; Lewin et al., 1992a; Ritter and Mendell, 1992). Here we show that administration of excess NGF to neonatal or mature animals can lead to a profound behavioral hyperalgesia. Neonatal NGF treatment (postnatal day 0-14) resulted in a profound mechanical hyperalgesia that persisted until the animals had reached maturity (6 weeks of ag...

    Chronic Chagas disease: from basics to laboratory medicine

    Haberland, A.; Saravia, S.G.; Wallukat, G.; Ziebig, R.; Schimke, I. (2013)
    Chagas disease, caused by Trypanosoma cruzi infection, is ranked as the most serious parasitic disease in Latin America and has huge potential to become a worldwide problem, due to increasing migration, and international tourism, as well as infectant transfer by blood contact and transfusion, intrauterine transfer, and organ transplantation. Nearly 30% of chronically-infected patients become symptomatic, often with a latency of 10-30 years, developing life-threatening complications. Of those,...

    Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process

    Lessard-Beaudoin, M.; Laroche, M.; Loudghi, A.; Demers, M.J.; Denault, J.B.; Grenier, G.; Riechers, S.P.; Wanker, E.E.; Graham, R.K. (2016)
    Caspases and their substrates are key mediators of apoptosis and strongly implicated in various physiological processes. As the serine/threonine kinase family is involved in apoptosis and serine/threonine kinase 3 (STK3) is a recently identified caspase-6 substrate, we assessed the expression and cleavage of STK3 in murine peripheral organs and brain regions during the aging process. We also assessed caspase-3, -6, -7, and -8 expression and activity in order to delineate potential mechanism(s...
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