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Institutional Repository for Molecular Medicine (MDC)
Publication Repository
2262 Publications


  • Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy

    Posch, M.G.; Perrot, A.; Dietz, R.; Oezcelik, C.; Pankuweit, S.; Ruppert, V.; Richter, A.; Maisch, B. (2007)

    A glycolytic solution for pluripotent stem cells

    Mlody, B.; Prigione, A. (2016)
    Glycolysis is an essential component of cellular metabolism associated with pluripotent stem cells (PSCs). Two new papers, one by Gu et al. (2016) in this issue of Cell Stem Cell and one by Zhang et al. (2016) in Cell Reports, demonstrate that glycolytic flux is dynamically increased in human primed PSCs upon feeder-free cultivation or conversion into the naive state.

    Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger

    Ifuku, M.; Faerber, K.; Okuno, Y.; Yamakawa, Y.; Miyamoto, T.; Nolte, C.; Merrino, V.F.; Kitada, S.; Iwamoto, T.; Komuro, I.; Wang, B.; Cheung, G.; Ishikawa, E.; Ooboshi, H.; Bader, M.;... (2007)
    Bradykinin (BK) is produced and acts at the site of injury and inflammation. In the CNS, migration of microglia toward the lesion site plays an important role pathologically. In the present study, we investigated the effect of BK on microglial migration. Increased motility of cultured microglia was mimicked by B1 receptor agonists and markedly inhibited by a B1 antagonist but not by a B2 receptor antagonist. BK induced chemotaxis in microglia isolated from wild-type and B2-knock-out mice but ...

    Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke

    Hoffmann, C.J.; Harms, U.; Rex, A.; Szulzewsky, F.; Wolf, S.A.; Grittner, U.; Laettig-Tuennemann, G.; Sendtner, M.; Kettenmann, H.; Dirnagl, U.; Endres, M.; Harms, C. (2015)
    BACKGROUND: Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS: We generated a tamoxifen-inducible and endothelial-specific Stat3 knockout mouse model by crossbreeding Stat3(floxed/KO) and Tie2-Cre(ERT2) mice. Cerebral ischemia was induced by 30 m...

    AKIMA interpolation: A tool used in direct slit-length desmearing procedures of non-frequency- limited X-ray scattering curves

    Mueller, J.J.; Mueller, E.C.; Gernat, C.; Kroeber, R. (1995)
    X-ray small- and medium-angle scattering of partially ordered or semicrystalline materials is composed of background scattering from the form scattering of the components and from the amorphous phase and of peaks from the scattering of the crystallites. By the slit geometry of X-ray diffractometers constructed for registration of small- and medium-angle X-ray scattering, the diffuse scattering and the peaks are distorted and the peak positions and half-widths are changed. A program module bas...
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