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Sierra Journals
Journal Aggregator/Publisher
37 Publications


  • Analytical Separation and Characterisation of Degradation Products and the Development and Validation of a Stability-Indicating Method for the Estimation of Impurities in Montelukast Oral Dosage Formulation

    Rasheed, Anas; Ahmed, Dr. Osman (2017)
    A short selective, precise, accurate and sensitive stability-indicating gradient LC-MS/MSn method was developed for the quantitative determination of process-related impurities and degradation products of Montelukast in pharmaceutical oral dosage formulations. During the stress study, the degradation products of Montelukast were well-resolved from Montelukast and its impurities and the mass balances were found to be satisfactory in all the stress conditions, thus proving the stability-indicat...

    Method Development and Validation of RP-HPLC Method for the Estimation of Ormeloxifene

    Shivaraj, Anusha; Battula, Shireesha (2017)
    A new simple, specific, accurate, precise RP-HPLC method has been developed for the estimation of Ormeloxifene. The chromatographic separation for Ormeloxifene was achieved with mobile phase containing methanol :ACN(70:30 v/v), agilent C18 column (4.6 x150 mm) 5 μ at room temperature and UV detection at 274nm.The compounds were eluted in the isocratic mode at a flow rate of 1ml/min. The retention time of Ormeloxifene was found to be 2.497min. The method was validated according to ICH guidelin...

    Formulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P

    Gopikrishna, Addanki; Ramu, B.; Srikanth, G.; Rajkamal, Dr.Bigala (2016)
    The aim of the present study was to develop sustained release formulation of Isoniazide to maintain constant therapeutic levels of the drug for over 12 hrs. Various polymers such as Guar gum, HPMCK100 M, PEG 6000 and Carbopol 934 p were employed as polymers. Isoniazide dose was fixed as 100 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 100, 150 and 200 mg. All the formulations passed various physicochemical evaluation parameters and they w...

    Antioxidant Activity of Dalbergia Melanoxylon Bark Extract

    U, Swetha (2017)
    The bark extract of Dalbergia melanoxylon (Fabaceae) was assessed for its antioxidant activity by in-vitro methods. This activity was evaluated by using various methods like hydrogen peroxide scavenging activity, Nitric oxide scavenging activity, DPPH radical scavenging activity and reducing power assay. Quantitative analysis of antioxidative components like total phenolic content, total flavonoid content and antioxidant capacity were estimated using spectrophotometric methods. The obtained r...

    Botanical and phyto-pharmacological reports on Stephania japhonica

    Hossain, Mohammad; Azad, Md. Abul Kalam; Tareq, Syed Mohammed; Islam, Muhammad Torequl (2017)
    Medicinal plants play a key role in the human health. The use of plants, plant parts and their derived products is ancient. To date, a number of medicinal plants have gained attention of the medicinal scientists for their important phytoconstituents and in the treatment of various diseases. The plants of the genus Stephania (Family: Menispermaceae) are widely distributed, and are being used in the folk medicine for the treatment of various ailments, such as asthma, tuberculosis, fever, dysent...
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    International Journal of Applied Pharmaceutical Sciences and Research 37
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