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Sierra Journals
Journal Aggregator/Publisher
38 Publications


  • Analytical Separation and Characterisation of Degradation Products and the Development and Validation of a Stability-Indicating Method for the Estimation of Impurities in Montelukast Oral Dosage Formulation

    Rasheed, Anas; Ahmed, Dr. Osman (2017)
    A short selective, precise, accurate and sensitive stability-indicating gradient LC-MS/MSn method was developed for the quantitative determination of process-related impurities and degradation products of Montelukast in pharmaceutical oral dosage formulations. During the stress study, the degradation products of Montelukast were well-resolved from Montelukast and its impurities and the mass balances were found to be satisfactory in all the stress conditions, thus proving the stability-indicat...

    Antioxidant Activity of Dalbergia Melanoxylon Bark Extract

    U, Swetha (2017)
    The bark extract of Dalbergia melanoxylon (Fabaceae) was assessed for its antioxidant activity by in-vitro methods. This activity was evaluated by using various methods like hydrogen peroxide scavenging activity, Nitric oxide scavenging activity, DPPH radical scavenging activity and reducing power assay. Quantitative analysis of antioxidative components like total phenolic content, total flavonoid content and antioxidant capacity were estimated using spectrophotometric methods. The obtained r...

    Method Development and Validation of RP-HPLC Method for the Estimation of Ormeloxifene

    Shivaraj, Anusha; Battula, Shireesha (2017)
    A new simple, specific, accurate, precise RP-HPLC method has been developed for the estimation of Ormeloxifene. The chromatographic separation for Ormeloxifene was achieved with mobile phase containing methanol :ACN(70:30 v/v), agilent C18 column (4.6 x150 mm) 5 μ at room temperature and UV detection at 274nm.The compounds were eluted in the isocratic mode at a flow rate of 1ml/min. The retention time of Ormeloxifene was found to be 2.497min. The method was validated according to ICH guidelin...

    In-Vivo Anthelmenthic Activity of Various Extracts of Eclipta Alba Leaves

    Reddy, Swetha Naram; Farhana, Azmath; A, Teja Sri; Anjum, Aliya; Bakshi, Vasudha (2017)
    Different extracts of E.alba were taken for anthelmintic activity against Indian earthworm Pheretima posthuma. Two concentrations (100 and 150 mg/ml) of various extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Albendazole (20 mg/ml) was used as reference standard. Dose dependent activity was observed in the plant extracts but ethanolic extract exhibited more activity as compared to others.

    Overview on Common Respiratory Virus

    Sagadevan, Dr. P.; Ramya, R.; Rathishkumar, S.; Vijayakumar, S.; Surendran, L; Janarthanan, P.; Sajith, C. (2018)
    Respiratory viruses have been recognised as causative agents for a wide spectrum of clinical manifestationsand severe respiratory compromise in neonates during birth hospitalisation. Early-life respiratory virus infectionshave also been shown to be associated with adverse long-term consequences. Preventing virus infectionsby intensifying hygiene measures and cohorting infected infants should be a major goal for neonatal intensivecare units, as well as more common use of virus diagnostics.
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    International Journal of Applied Pharmaceutical Sciences and Research 38
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