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Sierra Journals
Journal Aggregator/Publisher
36 Publications


  • Neuroprotective Effect of Garcinia Mangostana on Streptozotocin Induced Sporadic Type Alzheimer’s Disease in Mice

    P, Avinash; Reddy R, Arun; Begum, Nazia; Bakshi, Dr. Vasudha (2016)
     Objectives: The main objective of the study is to determine the neuroprotective potential of ethonolic extract of Garcinia mangostana (EEGM) in mouse against Intracerebroventricular- Streptozotocin (ICV –STZ) induced sporadic type Alzheimer‟s disease. Methods: Neurotoxicity was induced by ICV injection of STZ (0.5 mg/kg/b.w) as a first dose then the second dose after the 48 hours and the animals were pre-treated with ethanolic extract of Garcinia mangostana for 28 days. To assess the behavio...

    In-Vivo Anthelmenthic Activity of Various Extracts of Eclipta Alba Leaves

    Reddy, Swetha Naram; Farhana, Azmath; A, Teja Sri; Anjum, Aliya; Bakshi, Vasudha (2017)
    Different extracts of E.alba were taken for anthelmintic activity against Indian earthworm Pheretima posthuma. Two concentrations (100 and 150 mg/ml) of various extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Albendazole (20 mg/ml) was used as reference standard. Dose dependent activity was observed in the plant extracts but ethanolic extract exhibited more activity as compared to others.

    Development and evaluation of sustained release matrix tablets of losartan potassium

    Chandrasekhar, U.; Viswanath, V.; Narasimha Rao, B.; Gnana Prakash, K. (2016)
    The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios. Hydrophilic natural polymers like xanthan Gum (XG), guar gum and cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. Formul...

    Neuroprotective effect of Nevirapine on cerebral ischemic stroke by middle cerebral artery occlusion in wistar rats

    Ram, CH Maneesha; Begum, Nazia; Pathakala, Naveen; Bakshi, Dr. Vasudha (2016)
    Objective: To evaluate the neuroprotective effect of Nevirapine on cerebral ischemia stroke by middle cerebral artery occlusion in wistar rats.Methods:   The rats were pre and post treated with Nevirapine (NVP) at selective doses (5, 10 mg/kg/g, p.o) for a period of 14 days followed by middle cerebral artery occlusion (MCAO). Neurobehavioral changes were evaluated by using Y-maze and open field habituation. Biochemical markers such as acetyl cholinesterase (AChE), glutamate, differential leuk...

    Method Development and Its Validation for Simultaneous Estimation of Domperidone and Esomeprazole by RP-HPLC in Combination Tablet Dosage Form

    Reddy, V. Tejasvi; Kumar, S. Hari Hara; Haque, M Akiful; Bakshi, Dr. Vasudha (2016)
    A simple and validated reverse phase high performance liquid chromatography (RP-HPLC) method was developed for simultaneous estimation of Esomeprazole and Domperidone. Different HPLC Chromatographic conditions were used to find out the optimum chromatographic condition for best elution of drugs. Good chromatographic separation was achieved on Develosil ODS HG-5 RP C18 (15cmX4.6mm, 5mm Particle size), analytical column using a mixture of Potassium dihydrogen phosphate buffer pH: acetonitrile i...
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    International Journal of Applied Pharmaceutical Sciences and Research 36
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