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Journal of Circadian Rhythms
140 Publications
OpenAIRE 3.0 (OA, funding)


  • Circadian Rhythms, Exercise, and Cardiovascular Health

    Hower, Isabella M.; Harper, Sara A.; Buford, Thomas W. (2018)
    Human circadian rhythmicity is driven by a circadian clock comprised of two distinct components: the central clock, located in the suprachiasmatic nucleus (SCN) within the hypothalamus, and the peripheral clocks, located in almost all tissues and organ systems in the body. Entrainment, or alignment, of circadian rhythmicity is dependent upon time of day and can occur through environmental influences such as light cues and physical activity exerted on skeletal muscle. Entrainment of the circad...

    P19 Cells as a Model for Studying the Circadian Clock in Stem Cells before and after Cell Differentiation

    Mashhour, Abdullah; Al Mansour, Zainab; Al Hallaj, Al Shaima; Ali, Rizwan; Trivilegio, Thadeo; Boudjelal, Mohamed (2018)
    In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. Circadian rhythm is absent in undifferentiated embryonic stem cells; it begins only after differentiation. We used pluripotent P19 embryonal carcinoma stem cells to check the biological clock before and after differentiation into neurons using retinoic acid. We show that the central clock genes ARNTL (Bmal), Per2 and Per3, and the peripheral ...

    Are Type 2 Diabetes Mellitus and Depression Part of a Common Clock Genes Network?

    Karthikeyan, Ramanujam; Spence, David Warren; Brown, Gregory M.; Pandi-Perumal, Seithikurippu R. (2018)
    In recent years, there has been an increased prevalence of type 2 diabetes mellitus (T2DM) and depression across the world. This growing public health problem has produced an increasing socioeconomic burden to the populations of all affected countries. Despite an awareness by public health officials and medical researchers of the costs associated with these diseases, there still remain many aspects of how they develop that are not understood. In this article, we propose that the circadian clo...

    Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats

    Kawai, Hiroshi; Kodaira, Natsumi; Tanaka, Chika; Ishibashi, Takuya; Kudo, Naomi; Kawashima, Yoichi; Mitsumoto, Atsushi (2018)
    The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility ...

    Circadian behavior of mice deficient in PER1/PML or PER2/PML

    Miki, Takao; Chen-Goodspeed, Misty; Zhao, Zhaoyang; Lee, Cheng Chi (2013)
    Background Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML’s contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1−/−/Pml−/− and Per2−/−/Pml−/− genotypes. Results Here we report the circadian behavior of these mice based on wheel-running behavioral analysis. In a free...
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