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Experimental Biomedical Research
17 Publications


  • Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats

    Okur, Mehmet Hanifi; Zeytun, Hikmet; Basuguy, Erol; Aydogdu, Gulay; Alabalık, Ulas; Kaplan, Ibrahim; Akdeniz, Sevinc; Arslan, Serkan; Aydoğdu, Bahattin (2018)
    Aim: To investigate the effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion (I/R) in rats. Method: Forty male Wistar rats were randomly divided into 4 groups as group I (sham, n=10), group II (control, n=10), group III (I/R-untreated, n=10) and group IV (I/R-cordycepin, n=10). Liver ischemia was induced for 30 min then reperfusion was allowed for 1 h. At the end of the experiment, liver specimens and blood samples were taken f...

    Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis

    Kosekli, Mehmet Ali; Erkus, Edip; Kocak, Mehmet Zahid (2018)
    Aim: Hepatosteatosis confers increased lipid accumulation in the hepatocytes which is associated with inflammation. Hemogram parameters, such as mean platelet volume (MPV) and MPV to platelet ratio (MPR) are proposed as novel inflammatory markers in recent studies. We aimed to compare MPR of subjects with hepatosteatosis to those in healthy controls. Methods: Patient admissions to our clinic with a diagnosis of hepatosteatosis were retrospectively analyzed MPR values compared to those in h...

    Patients’ misperception regarding the difficulty of lumbar puncture

    Ogun, Muhammed Nur; Onerli, Merve (2018)
    Aim: Lumbar puncture (LP) is a crucial method of diagnosis and treatment of neurological diseases. Despite its importance, the patients' refusal of the procedure leads to difficulties in diagnosis and treatment. One of the main reasons for patients’ refusal may be that LP is perceived to be more difficult than it actually is. Our aim was to investigate whether the patients had prejudices against the difficulty of LP treatment. Methods: Sixty-seven patients aged between 20 and 80 years were...

    Surgical treatment with rhomboid excision and Limberg flap technique under spinal anesthesia of 23 young with pilonidal sinus disease

    Ozturk, Hulya; Yoldas, Hamit; Karagoz, Ibrahim (2018)
    Aim: To present the experience of treatment with Limberg flap procedure under spinal anesthesia in 23 young patients with pilonidal sinus disease. Methods: This was a retrospective study of 23 young patients who underwent surgery for pilonidal sinus disease under spinal anesthesia between January 2011 and November 2017 in the Division of Pediatric Surgery. All patients were evaluated for age, sex, clinical diagnosis, and body mass index, and infection, duration of symptoms, treatment, heal...

    Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats

    Taskiran, Ahmet Sevki; Ozdemir, Ercan; Arslan, Gokhan; Tastemur, Yasar; Filiz, Ahmet Kemal (2018)
    Aim: Tadalafil is a potent, selective and reversible inhibitor of phosphodiesterase type 5 (PDE5) enzyme breakdowning cyclic guanosine monophosphate (cGMP). In this study, we aimed to investigate the effects of tadalafil on nociception, morphine analgesia and tolerance. Methods: In this study, 54 Wistar Albino (230-250 g) male rats were used. First of all, four different doses (2, 4, 8, 16 mg/kg) were used to determine the optimum effective dose of tadalafil on nociception. Optimum ac...
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