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Journal of Molecular Signaling
135 Publications
OpenAIRE 3.0 (OA, funding)


  • Transcriptional and Post-Translational Targeting of Myocyte Stress Protein 1 (MS1) by the JNK Pathway in Cardiac Myocytes

    Hay, Joanna M.; Jordan, Eva S.; Browne, Gareth J.; Bottrill, Andrew R; Prigent, Sally A.; Dickens, Martin (2017)
    Myocyte Stress Protein 1 (MS1) is a muscle-specific, stress-responsive, regulator of gene expression. It was originally identified in embryonic mouse heart which showed increased expression in a rat model of left ventricular hypertrophy. To determine if MS1 was responsive to other stresses relevant to cardiac myocyte function, we tested if it could be induced by the metabolic stresses associated with ischaemia/reperfusion injury in cardiac myocytes. We found that metabolic stress increased MS...

    EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5

    Fekete, Anna; B?gel, G?bor; Pesti, Szabolcs; P?terfi, Zal?n; Geiszt, Mikl?s; Buday, L?szl? (2013)
    Background: Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. Recent data have suggested that a close homologue of Tks5, Tks4, is implicated in the EGF signaling.Results: Here, we report that Tks5 is a component of the EGF signaling pathway. In EGF-treated cells, Tks5 is tyrosine phosphorylated within minutes and th...

    A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1

    Jiang, Yan; Puliyappadamba, Vineshkumar T; Zhang, Liyue; Wu, Wenjuan; Wali, Anil; Yaffe, Michael B; Fontana, Joseph A; Rishi, Arun K (2010)
    Background: CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood.Results: Here we investigated whether CARP-1 is involved in signaling induced by the protein kinase A inhibitor H89. Treatments of human breast cancer cells with H89 resulted in apoptosis that involved enhanced CARP-1 threonine phosphorylation and expression. Depletion of CARP-...

    Seminal plasma induces the expression of IL-1α in normal and neoplastic cervical cells via EP2/EGFR/PI3K/AKT pathway

    Adefuye, Anthonio O; Sales, Kurt J; Katz, Arieh A (2014)
    Background: Cervical cancer is a chronic inflammatory disease of multifactorial etiology usually presenting in sexually active women. Exposure of neoplastic cervical epithelial cells to seminal plasma (SP) has been shown to promote the growth of cancer cells in vitro and tumors in vivo by inducing the expression of inflammatory mediators including pro-inflammatory cytokines. IL-1α is a pleotropic pro-inflammatory cytokine induced in several human cancers and has been associated with virulent ...

    Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation

    Bertalovitz, Alexander C.; Pau, Milly S.; Gao, Shujuan; Malbon, Craig C.; Wang, Hsien-yu (2016)
    Projects: NIH | Cyclic GMP Phosphodiesterase in Signaling (5R01GM069375-04), NIH | STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORS (2R01DK025410-26)
    The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.
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