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Maynooth University ePrints & eTheses Archive
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8136 Publications
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  • Mechanism-based Inhibition: Deriving KI and kinact directly from Time-Dependent IC50 Values

    Krippendorff, Ben-Fillippo; Neuhaus, Roland; Lienau, Philip; Reichel, Andreas; Huisinga, Wilhelm (2009)
    The potential of enzyme inhibition of a drug is frequently quantified in terms of IC50 values. While this is a suitable quantity for reversible inhibitors, concerns arise when dealing with irreversible, or mechanism-based inhibitors (MBI). IC50 values of MBI are time-dependent, causing serious problems when aiming at ranking different compounds with respect to their inhibitory potential. As a consequence, most studies and ranking schemes related to MBI rely on the inhibition constant (KI) ...

    Neutrality in the balance. Spanish-German relations during the First World War, 1914-1918

    Rosenbusch, Anne (2015)
    There is no abstract for this thesis.

    Cascaded multilevel inverter with regeneration capability and reduced number of switches

    Lezana, Pablo; Rodríguez, José; Oyarzún, Diego A. (2009)
    Abstract—multilevel converters are a very interesting alternative for medium and high power drives. One of the more flexible topologies of this type is the cascaded multicell converter. This paper proposes the use of a single-phase reduced cell suitable for cascaded multilevel converters. This cell uses a reduced singlephase active rectifier at the input and an H-bridge inverter at the output side. This topology presents a very good performance, effectively controlling the waveform of the ...

    MEG source localization using an MLP with a distributed output representation

    Jun, Sung Chan; Pearlmutter, Barak A.; Nolte, Guido (2003)
    We present a system that takes realistic magnetoencephalographic (MEG) signals and localizes a single dipole to reasonable accuracy in real time. At its heart is a multilayer perceptron (MLP) which takes the sensor measurements as inputs, uses one hidden layer, and generates as outputs the amplitudes of receptive fields holding a distributed representation of the dipole location. We trained this Soft-MLP on dipolar sources with real brain noise and converted the network's output into an expli...

    Suicide ideation, psychological adjustment and mental health service support: A screening study in an Irish secondary school sample

    Brennan, Ciara; McGilloway, Sinéad (2012)
    Objective: The aim of this exploratory study was to investigate the extent of suicide ideation, psychological maladjustment and views of mental health service support in a sample of secondary school pupils. Method: A cross-sectional survey was conducted on a purposive sample of participants (n=93) recruited from a secondary school located in the south east of Ireland. Participants completed a Background Information Questionnaire (BIQ); the Suicide Ideation Questionnaire (SIQ); and the Rey...
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