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Oxford University Research Archive
Institutional Repository
8532 Publications
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  • The structural basis for CD36 binding by the malaria parasite.

    CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty acids. It is also the most common target of the PfEMP1 proteins of the malaria parasite, Plasmodium falciparum, tethering parasite-infected erythrocytes to endothelial receptors. This prevents their destruction by splenic clearance and allows increased parasitaemia. Here we describe the structure of CD36 in complex...

    Quality of life in patients treated with first-line antiretroviral therapy containing nevirapine or efavirenz in Uganda: a prospective non-randomized study

    Background The goal of antiretroviral therapy (ART) is to suppress viral replication, reduce morbidity and mortality, and improve quality of life (QoL). For resource-limited settings, the World Health Organization recommends a first-line regimen of two-nucleoside reverse-transcriptase inhibitors and one non-nucleoside transcriptase inhibitor (nevirapine (NVP) or efavirenz (EFV)). There are few data comparing the QoL impact of NVP versus EFV. This study assessed the change in QoL and factor...

    Food, agriculture and nanotechnology: applying the Snow White Test to the Nano-Apple

    Eight consumer surveys over five years, with over eight thousand subjects and across two continents yield three clear results. They are that, firstly, consumers are generally ignorant about nanotechnology, secondly, they are generally optimistic about nanotechnology and, thirdly, despite the general optimism, they draw the line at food, they do not want nanotechnology in their food. Nano-food fails the Snow White Test: Would the transaction proceed if, between the parties, there was symmetry ...

    Unseen professional learning mediated by networked technology in an academic context

    Recent technological advances are providing new and exciting opportunities for researchers to work together across the conventional boundaries of time, distance, and discipline. These advances have formed new networks of research, both in electronic mediums and in face-to-face environments, different from traditional networks in terms of their changing nature and scope. Such networks potentially provide rich opportunities for informal and unplanned professional learning of academics involved ...

    Models for polythermal ice sheets and glaciers

    Polythermal ice sheets and glaciers contain both cold ice and temperate ice. We present two new models to describe the temperature and water-content of such ice masses, accounting for the possibility of gravity- and pressure-driven water drainage according to Darcy's law. Both models are based on the principle of energy conservation; one additionally invokes the theory of viscous compaction to calculate pore water pressure, and the other involves a modification of existing enthalpy gradient m...
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