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Name
EprintsUnife
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Institutional Repository
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947 Publications
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OpenAIRE Basic (DRIVER OA)
OAI-PMH
http://eprints.unife.it/cgi/oai2
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  • Whole transcriptome expression profiling in collagen VI myopathies KO mice reveals muscle-specific fingerprints and arises the role of circadian clock genes as myopathy biomarkers

    Collagen VI is an extracellular matix protein that forms a microfilamentous network in skeletal muscles and other organs. In humans, mutations in the collagen VI alpha1, 2 and 3 genes cause congenital muscular dystrophies as Bethlem , Ullrich and Myosclerosis. Mitochondrial pore abnormalities and defect in the autophagic pathways have been identified both in patients and in Col6a2KO mouse model. In order to bridging these findings to the transcriptome, we have performed whole expression profi...

    STUDIO DELLA COMBUSTIONE IN SISTEMI ENERGETICI PER LA MICROCOGENERAZIONE

    In recent years, distributed microcogeneration systems have received a renewed attention. In this work two different microcogenerative energetic systems have been analyzed and presented: micro gas turbine (MGT) and thermophotovoltaic (TPV) systems. The knowledge of combustion process inside combustion chamber of these systems is one of the most crictical aspects in the analysis of the performance and of the operation conditions. A CFD analysis, constituted by solid modeli...

    Molecular mechanisms impairing biosynthesis and function of hemostatic proteins

    The gene mutations leading to hemorrhagic disorders provide peculiar models to elucidate molecular mechanisms underlying protein biosynthesis, and the relationship between the structure and function. The research activity has been focused on the molecular defects leading to severe deficiency of Factor IX (FIX), a serine protease with a key role in the intrinsic pathway of blood coagulation, and of von Willebrand factor (VWF), a large multimeric protein essential for the primary hemostasis....

    THE A3 ADENOSINE RECEPTOR: A LINK BETWEEN INFLAMMATION AND CANCER.

    Adenosine is an endogenous and ubiquitous nucleoside that exerts many biological functions through interaction with 4 distinct subtypes of G protein-coupled receptors divided into A1, A2A, A2B, and A3. This nucleoside plays an important role in modulating inflammation and tumorigenesis. In the past most of the anti-inflammatory effects of this nucleoside were thought to be due to the activation of the A2A subtype, however more recently, the involvement of the A3 subtype has bee...
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