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UCL Discovery
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43313 Publications
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  • Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-induced apoptosis

    Three prevalent mitochondrial DNA pathogenic mutations at positions 11778, 3460, and 14484, which affect different subunits of Complex I, cause retinal ganglion cell death and optic nerve atrophy in Leber's hereditary optic neuropathy (LHON). The cell death is painless and without inflammation, consistent with an apoptotic mechanism. We have investigated the possibility that the LHON mutation confers a pro-apoptotic stimulus and have tested the sensitivity of osteosarcoma-derived cybrid cells...

    Biochemical aspects of chronic hyperoxia in mammals

    The primary objective of the work described in this thesis was to investigate some of the effects of chronic oxygen toxicity in mammals. This thesis describes in vivo changes in certain metabolites and enzymes following the exposure of mice and rats to increased concentrations of oxygen at atmospheric pressure. The introductory section reviews the historical background to oxygen toxicity, delineates its two forms and describes their aetiology. The physical and chemical pr...

    RET receptor tyrosine kinase architecture, protein interactions and chemical inhibition

    The RET receptor tyrosine kinase plays a major role in embryonic and adult vertebrate development. Deregulation of RET signalling leads directly to multiple human diseases. Like many receptor tyrosine kinases, the intracellular tyrosine kinase domain of RET is activated by binding of ligand/co-receptor to its ectodomain (ECD). RET is unique among receptor tyrosine kinases, possessing cadherin-like domains (CLD1–4) within its ECD. This thesis describes the architecture of the RET-ECD elucidate...

    Trichomonas vaginalis infection is uncommon in the British general population: implications for clinical testing and public health screening.

    INTRODUCTION: Variable use of new molecular assays, asymptomatic infections and a lack of population data mean that the population burden of Trichomonas vaginalis is uncertain. We investigated the age-specific prevalence of T. vaginalis within the sexually active British general population to inform testing strategies. METHODS: Britain's third National Survey of Sexual Attitudes and Lifestyle (Natsal-3) is a probability sample survey of 15 162 individuals aged 16-74 years, undertaken during 2...

    Land policies in Delhi: their contribution to unauthorised land development

    Government intervention in land markets through public land policies increasingly sought for a more balanced development, better income and wealth distribution, and to satisfy the basic human needs such as housing and essential services in developing countries. Delhi's large-scale land acquisition, development and disposal policy has aimed at orderly growth of planned development, and universal access to housing land through public expropriation, banking, development and delive...
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