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UCL Discovery
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  • Studies towards the total synthesis of tagetitoxin

    Sehailia, M. (2011)
    Tagetitoxin is a phytotoxin produced by the bacterium Pseudomonas syringae pv. tagetis. It is a selective inhibitor of RNA polymerase III in eukaryotic cells and RNA polymerase in bacteria. To date, no total synthesis of the proposed structure of tagetitoxin has been reported. While there is some ambiguity surrounding the structure of tagetitoxin, the most likely structure incorporates a unique 9-oxa-thiabicyclo[3.3.1]nonane core, with six stereogenic centres and a range of fun...

    Supporting young people on the edge of entering public care: cross national perspectives [IOE Research Briefing N�4]

    Statham, J. (2013)
    This study examines public care and support services for young people at risk of entering care in other European countries and the lessons that can be learnt for England’s care system. IOE Research Briefings are short descriptions of significant research findings, based on the wide range of projects carried out by IOE researchers.

    The material culture of children's play: Space, toys and the commoditization of childhood in a Greek community.

    Gougoulis, G-C (2004)
    This thesis is an ethnography of children's play in Palaia Phocaea of Attica Greece, with a particular focus on its material aspects: the spaces and objects of children's playful interactions with the social world. The evidence is also used to discuss various theories as to the impact of the commoditization of toys. Chapter 1 introduces the theoretical perspectives adopted throughout the thesis and the key concepts employed such as the notion of interpretive reproduction and ...

    Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.

    Leverrier, Y.; Okkenhaug, K.; Sawyer, C.; Bilancio, A.; Vanhaesebroeck, B.; Ridley, A. J. (2003)
    Phosphoinositide 3-kinases (PI3Ks) play an important role in a variety of cellular functions, including phagocytosis. PI3Ks are activated during phagocytosis induced by several receptors and have been shown to be required for phagocytosis through the use of inhibitors such as wortmannin and LY294002. Mammalian cells have multiple isoforms of PI3K, and the role of the individual isoforms during phagocytosis has not been addressed. The class I PI3Ks consist of a catalytic p110 isoform associate...
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