Halley, J. (2007)Envelope glycoproteins of HIV-1 (gp160>gp120/41) and HIV-2 (gp140>gp105/36) have -40% sequence identity, bind cell surface receptors (CD4 and CCR5 or CXCR4) and effect membrane fusion, suggesting a close structural similarity. HIV-2 gp140 is more stable than HIV-1 gp160 (Sattentau et al., 1993), possibly making it a better candidate for structural studies. We have generated HIV-2 env-gene constructs that allow expression of soluble gp120 (gp105 with a truncated gp36 gp15 lacking the membrane ...Prokos, P. (2005)Salt weathering, apart from being an important geomorphologic agent, comprises a major hazard for both modern and heritage structures. Although its action is witnessed globally, it is particularly aggressive in coastal environments. The coastline attracted in antiquity a considerable part of human activity that has left valuable built traces. Conservation research is frequently called upon to define sustainability in this aggressive context. Wall paintings comprise an integral part of the bui...Nicoloutsopoulos, D. (2005)This thesis studies parametric and non-parametric methods of cop ula estimation with special focus on the Archimedean class of copu las. The first part proposes an estimation procedure which is indepen dent of the marginal distributions and performs well for one-parame ter or two-parameter families of copulas, where traditional methods give questionable results especially for small sample sizes. In the sec ond part we follow a Bayesian methodology and represent the copula density as a random ...Asthana, H. (2014)In this thesis we provide a framework for a micro-blogging social network in an unstructured peer-to-peer network. At a user level, a micro-blogging service provides (i) a means for publishing a micro-blog, (ii) a means to follow a micro-blogger, and (iii) a means to search for micro-blogs containing keywords. Since unstructured peer-to-peer networks do not bind either the data or the location of data to the nodes in the network, search in an unstructured network is necessarily probabilistic....
Anti-Tumor Effects of TRAIL-Expressing Mesenchymal Stromal Cells in a Mouse Xenograft Model of Human MesotheliomaSage, E.; Janes, S. M. (2015)
Projects: NIH | Bioengineering New Lungs from Cadaveric Lung Scaffolds (1RC4HL106625-01), NIH | Use of 3-D Culture and Stretch to Develop Lung from MSCs, ESCs, and iPS (1R21HL094611-01A2), WT, NIH | De-Cellularized Human Lungs for Ex Vivo Lung Regeneration (5R21HL108689-02), NIH | PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS (3P40RR017447-04S1), NIH | ENVIRONMENTAL PATHOLOGY (2T32ES007122-11), NIH | Multidisciplinary Training in Lung Biology (5T32HL076122-10), NIH | TRANSLATIONAL RESEARCH IN LUNG BIOLOGY AND DISEASE (5P20RR015557-04)Malignant mesothelioma (MM) remains a highly deadly malignancy with poor treatment option. The MM cells further promote a highly inflammatory microenvironment which contributes to tumor initiation, development, severity, and propagation. We reasoned that the anti-inflammatory actions of mesenchymal stromal cells (MSCs) and further anti-tumor effects of MSCs engineered to over-express TNF-related apoptosis inducing ligand (TRAIL) protein (MSC-TRAIL) would effectively inhibit mesothelioma growt...
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