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Publications from Karolinska Institutet
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7420 Publications
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  • Regulation of cytochrome P450 2E1 by hyperoxia and inflammatory factors, with special reference to the central nervous system

    Cytochrome P450 2E1(CYP2E1) is a mammalian member of the large P450 gene superfamily. CYP2E1 is active in the metabolism of many small hydrophobic substrates, including general anesthetics, muscle relaxants, precarcinogens, and organic solvents. CYP2E1 is, however, active also in acetone hydroxylation and the enzyme is specifically regulated during conditions of fasting and during diabetic states, as well as by insulin. The pathway initiated by CYP2E1 by acetone hyd...

    Hypertension : Epidemiological studies of prevalence, prevention, treatment and prognoses in men and women

    Background and aim: Hypertension is ranked as the leading risk factor for mortality and the third most common factor leading to disability in the world. Hence, detection, treatment, prevention and control are of high priority. The aim of this thesis was to study the prevalence of both diagnosed hypertension and newly diagnosed high blood pressure (unknown hypertension) and how well diagnosed hypertension is treated in Stockholm County, an urbanized region of Sweden. In addit...

    Intravenous morphine after gynecological surgery : pain relief, endocrine and immune respone

    Background: We need more efficient methods to alleviate postoperative pain and reduce endocrine / immune stress response. Subjects and methods: Patient controlled analgesia (PCA) with iv morphine was evaluated with respect to pain relief and endocrine / immune response to surgical trauma in 130 patients undergoing gynecological surgery. Anesthetic regimens included general anesthesia, epidural anesthesia, epidural morphine and combinations of these methods. Results: Lar...

    From stem cell to neuron : A sox perspective

    The differentiation of stem cells into the more than 100 billion neurons that compose the central nervous system (CNS) is one of the most remarkable transformations during vertebrate development. A central problem of this process is how neural lineage selection initially is specified in pluripotent stem cells and maintained during the course of neurogenesis. This thesis focuses on how different Sox transcription factors of the HMG-box family control neural cell-type restrict...

    Experimental nerve injury - induced pain : Mechanisms and modulation

    Chronic nerve injury-induced pain presents a therapeutic challenge since such pain is often resistant to conventional analgesic drugs including opioids. Better knowledge of the pathophysiological mechanisms underlying nerve injuryinduced pain is necessary to develop new and more efficacious therapies. Peripheral nerve trauma often leads to a state of sensitization caused by complex mechanisms involving both peripheral and central events and processing. The sensitized stat...
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