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Publications from Karolinska Institutet
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7548 Publications
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  • Motivations and Deterrents to Take Part in an HIV Vaccine Trial: Experiences from Study Participants in Dar es Salaam, Tanzania

    Background: As HIV infection continues to be a public health problem, development of an effective preventive HIV vaccine is a priority. For the ultimate development of an AIDS vaccine, clinical trials are being conducted throughout the world. However, the process of developing the vaccine does not only depend on identification of suitable trial candidates, but also requires knowledge of incentives to participate in the community where the trial is being conducted. Therefore, the studies prese...

    Participation in leisure activities of children and youths with and without disabilities

    The World Health Organization (WHO) defines participation as a person’s involvement in a life situation, and to participate in leisure activities is one of the most important aspects of health and well-being. When a child is involved and engaged in a leisure activity, it gives the child a sense of belonging, opportunities to make friendships, and possibilities to develop physical and social competences and skills. Children with disabilities tend to be restricted in their a...

    Towards understanding patients' and caregivers' assessments of symptoms and quality of life in lung cancer

    Lung cancer is associated with a wide range of symptoms arising from both disease progression and treatment side effects. Nurses caring for patients with lung cancer are thus challenged to help patients cope with a variety of problems. Individual perspectives, influences and experiences are of great importance to consider when interpreting patients and caregivers assessments of symptoms and quality of life. The overall aim of this thesis is to gain better understanding of...

    On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate

    Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. In this way, DNA can be tightly packaged in the cell. The N-terminal tails, that protrude out from the histone surfaces can be subjected t...

    Modulation of cellular mechanisms in a spinal locomotor network

    Neuronal networks generate behaviour. Thus, to understandbehaviour requires information on how neuronal networks work in termsof their cellular cornponents. The overall aim of this work has beento link proccsses occuring at an ionic level to the operation of aneural network specialized for undulatory locomotion. To this end, we have combined physiological experiments withcomputational techniques in the analysis, using the lamprey spinallocomotor network as a model system...
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