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Name
Open Archive: Publications from Karolinska Institutet
Type
Institutional Repository
Items
7771 Publications
Compatibility
OpenAIRE Basic (DRIVER OA)
OAI-PMH
http://publications.ki.se/oai/request
More information
Detailed data provider information (OpenDOAR)

 

  • Role of GLP-1 receptor agonists in endothelial function

    Erdogdu, Özlem (2012)
    BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. The aim of this work was to evaluate the putative role and potential effects of incretins i.e. GLP-1 and exendin-4 on the vasculature and...

    Regulation of NMDA receptor properties by amino acids and cations : A biochemical and electrophysiological study

    Liu, Yun (1997)
    NMDA receptors are glutamate-regulated ion channels that arepermeable to Ca2+, Na+ and K+ andare sensitive to voltage-dependent Mg2+-block. Toinvestigate the modulatory effects of amino acids and cations on NMDAreceptors and the possible regional differences in the pharmacologyof NMDA receptors, I used mainly two techniques in this thesis:electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801in membran...

    Characterization of adipose factors regulated by body weight

    Mejhert, Niklas (2013)
    White adipose tissue (WAT) constitutes our most expandable tissue and largest endocrine organ secreting hundreds of polypeptides collectively termed adipokines. Changes in WAT mass induce alterations in adipocyte secretion and function, which are linked to disturbed whole-body metabolism. Although the mechanisms controlling this are not clear they are dependent on changes in gene expression, a complex process which is regulated at several levels. Results in recent years have hi...

    Immunological and virologica response to antiretroviral treatment (art) in patients infected with different HIV-1 genetic subtypes

    Atlas, Ann (2006)
    Genetic analyses of different strains of HIV- 1 have shown that isolates can be subdivided into groups, subtypes and circulating recombinant forms. Nine different genetic HIV-1 subtypes have been identified so far, named as A, B, C, D, F, G, H, J and K. An increasing interest has emerged on the outcome of antiretroviral therapy (ART) in patients infected with non-B HIV-1 genetic subtypes since global initiatives are planned to provide ART to patients resident in Continents w...

    Development of working memory, speech perception and auditory temporal resolution in children with allention deficit hyperactivity disorder and language impairment

    Norrelgen, Fritjof (2002)
    Speech perception (SP), verbal working memory (WM) and auditory temporal resolution (ATR) have been studied in children with attention deficit hyperactivity disorder (ADHD) and language impairment (LI), as well as in reference groups of typically developed children. A computerised method was developed, in which discrimination of same or different pairs of stimuli was tested. In a functional Magnetic Resonance Imaging (fMRI) study a similar test was used to explore the neural...
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