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Name
Publications from Karolinska Institutet
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Institutional Repository
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7282 Publications
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OpenAIRE Basic (DRIVER OA)
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http://publications.ki.se/oai/request
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  • Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria

    Excessive sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) and uninfected erythrocytes directly blocks the microcirculation and precipitates severe symptoms from the affected organ and is thereby thought to be responsible for the severe complications which may occur during P. falciparum infection. Binding of infected erythrocytes to the microvascular endothelium (cytoadherence), to uninfected erythrocytes (rosetting) and to infected erythrocytes (autoagglu...

    Factors related to outcome in patients with traumatic brain injury : With special reference to analysis with machine learning methods

    Traumatic brain injury (TBI) is a leading cause of death in trauma. Neurointensive care (NICU) units have emerged to optimize treatments of the injured brain. The main objective is to identify and avoid conditions that lead to further insult and potential cell death. Treatments are based on multimodal monitoring, which includes imaging techniques and monitoring of physiological and biochemical processes, from whole brain to the cellular level. The relationships between the n...

    Aspects of aetiology, pathoanatomy and diagnostic methods in chronic mid-portion achillodynia

    The objectives of this thesis are to study aetiology and pathoanatomy, and toevaluate diagnostic methods in patients with long-standing pain and tenderness localisedto the mid portion of the Achilles tendon. Treatment had failed to relieve symptomsprior to referral to our clinic, where some of these patients underwent surgicaltreatment. Fifty eight patients, derived from 60 consecutive operations, were analysed regardinghistory, clinical assessment, ultrasound, histopath...

    Colorectal cancer : aspects of multidisciplinary treatment, metastatic disease and sexual function

    More than 6000 people in Sweden are diagnosed with colorectal cancer annually. One out of five patients already has metastases at diagnosis. However, the occurrences of metastases at specific locations, e.g. peritoneal carcinomatosis and ovarian metastases, are not well known. The development of surgical and oncological treatment strategies for primary tumours and metastatic disease has led to a need to discuss colorectal cancer patients in a multidisciplinary team (MDT). Altho...

    Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids

    Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. Insulin- and C-peptide stimulated Na+,K+-ATPase activation, as assessed by ouabain-sensitive 86Rb+ uptake and 3H-ouabain binding, phosphorylation of α- and translocation of α- and β-subunits ...
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