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Publications from Karolinska Institutet
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7457 Publications
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  • Persistence of polyomavirus : versus immunity to polyoma tumors

    The aim of this thesis was to understand the role of different specific immune effectors with regard to polyomavirus persistence and polyomavirus induced tumor development. Furthermore, an MHC class I restricted short viral peptide was identified as a target for polyomavirus specific recognition of polyoma tumor cells. Persistence of polyomavirus was followed with a polyoma specific polymerase chain reaction (PCR) in immunocompetent and immunodeficient mice. Persistent p...

    Evaluation of a client-centred ADL intervention after stroke : perspectives of occupational therapists, clients with stroke and significant others

    The overall aim of this thesis is to build knowledge of a new client-centred activities of daily living (ADL) intervention (CADL), which takes the unique experiences of persons with stroke as the point of departure, and aims to enable agency in daily activities and participation in everyday life among persons with stroke. The focus of this thesis is an evaluation of CADL after stroke, from the perspectives of occupational therapists (OT), clients with stroke and their significant others. ...

    Patienters upplevelse av tvångsåtgärder inom psykiatrisk slutenvård : en litteraturstudie

    Background: Psychiatric inpatient care and coercion measures are stigmatized areas which represent a special part of the healthcare, since it’s in conflict with the principle of the right to voluntary care and treatment. This creates complicated ethical dilemmas and challenges the integrity of the individual. Purpose: To investigate the patients' experience of coercion measures in psychiatric inpatient care. Method: The design of the study is a literature study. The literature wer...

    Uveal melanoma and macular degeneration : Molecular biology and potential therapeutic applications

    Uveal melanoma is the most common primary intraocular malignant tumor in adults with 30% to 50% of patients that ultimately succumb to metastatic disease, mainly to the liver. Although new diagnostic and therapeutic tools have been developed during the most recent years, only the eye conservation rate has been achieved, while the survival rate remains poor. Neovascular age-related macular degeneration (AMD) is a disease where abnormal blood vessels grow in the macula and cau...

    Clinical and pathophysiological aspects of sepsis

    Severe sepsis and septic shock represent challenging problems for the health care system. Despite adequate antibiotics and modern intensive care, severe sepsis is associated with a substantial mortality rate of around 30%, which rises even higher if exacerbated by septic shock, and the incidence continues to increase. In severe sepsis and septic shock, the normally tightly controlled balance between the inflammatory, coagulatory and neuroendocrine systems is lost. Our unde...
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