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Publications from Karolinska Institutet
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7663 Publications
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  • Genomic and non-genomic effects of a new sodium-sensing network in renal and lung epithelia

    Eneling, Kristina (2012)
    Sodium and water homeostasis is crucial for cell function, survival and health of the individual. The kidney is responsible for sodium regulation in the body, balancing sodium secretion and reabsorption, and thereby also regulating the blood pressure, primarily via the Na+, K -ATPase. The Na+, K+ -ATPase is situated in the basolateral part of the polarized cell membrane and drives the vectorial transport of Na+ over the epithelium and water follows the ionic gradient. Vect...

    Gene regulation, intracellular signaling and membrane traffic : Studies in primary human skeletal muscle cultures

    Al-Khalili, Lubna (2004)
    Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. In this thesis primary human skeletal muscle cell culture (HSMC) has been used to investigate gene regulation, cellular signaling and membrane traffic. The expression of several myogenic and insulin responsive proteins, as we...

    ER subtype-specific regulation of estrogen signaling

    Cai, Wen (2011)
    The estrogen receptor (ER) isoforms, ERα and ERβ, mediate the physiological functions of the female hormone estrogen. They share high degree of similarity but also show significant differences in many aspects, such as cell and tissue distribution. The activities of ER are tightly regulated by different factors at multiple levels. The biological action of estrogen is the result of a balance between ERα and ERβ activities; and disruption of this balance leads to various health di...

    Hypospadias and increased risk for neurodevelopmental disorders

    Butwicka, Agnieszka; Lichtenstein, Paul; Landén, Mikael; Nordenvall, Anna; Nordenström, Anna; Nordenskjöld, Agneta; Frisén, Louise (2014)
    BACKGROUND: Hypospadias (aberrant opening of the urethra on the underside of the penis) occurs in 1 per 300 newborn boys. It has been previously unknown whether this common malformation is associated with increased psychiatric morbidity later in life. Studies of individuals with hypospadias also provide an opportunity to examine whether difference in androgen signaling is related to neurodevelopmental disorders. To elucidate the mechanisms behind ...

    Time Elapsed from Onset of Symptoms to Diagnosis of Gonorrhoea in Swedish Patients, 1999-2009

    Kader, Manzur; Sharma, Arpana; Velicko, Inga; Ahmad, Meraj (2014)
    Background: Gonococcal infection remains an important public health problem worldwide. The incidence of reported gonorrhoea cases in Sweden raised by 32%, from 5.9 to 7.8 cases per 100,000 in 2001 to 2008.The aim of this study is to estimate the lag time or time elapsed between onset of symptoms and diagnosis of gonorrhoea, and to identify the factors associated with diagnostic delay in a sample of reported gonorrhoea cases in Sweden. Methods: A retrospective cohort study was conducted ...
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