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Publications from Karolinska Institutet
Institutional Repository
7259 Publications
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  • Vaccination in gastrointestinal cancer

    Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting immune response against the tumour with limited toxicity on normal cells. Most tumour cells express tumour-associated antigens (TAA), which can act as targets for the immune system. However, most TAAs evade recognition by the immune system to avoid auto-immunity, as many...

    Role of GLP-1 receptor agonists in endothelial function

    BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. The aim of this work was to evaluate the putative role and potential effects of incretins i.e. GLP-1 and exendin-4 on the vasculature and...

    In vitro studies on intestinal epithelial cell proliferation : effects of cytokines, Helicobacter pylori, serotonin and neuroendocrine peptides

    Previous studies suggest that bacteria and bacterial metabolites, proinflammatory cytokines, neuroendocrine peptides and amines may participate in the regulation of the gastrointestinal -epithelial cell kinetics. The complexity of interactions that take place in vivo makes it difficult to define the primary actions of these and other agents on gastrointestinal cell proliferation. Thus in the present study we examine in vitro the actions on intestinal epithelial cell prolifer...

    Risk factors for prostate cancer : analysis of primary data, pooling, and related methodological aspects

    Prostate cancer is the second most common cancer among men worldwide, yet its etiology remains poorly understood. Obesity, on the other hand, is a prevalent but preventable medical condition that is associated with hormonal and metabolic changes. Since prostate cancer is a hormone-related cancer, the hypothesis of a link between body fatness and prostate cancer risk has been formulated. Furthermore, the considerable biologic heterogeneity of prostate cancer warrants analyses to be...

    Endothelin-1 in the regulation of vascular function and glucose metabolism in insulin resistance

    Insulin resistance plays a major role in the pathogenesis of type 2 diabetes and is an important risk factor for cardiovascular disease. Endothelial dysfunction, characterized by reduced bioactivity of nitric oxide and increased activity of the vasoconstrictor and pro-inflammatory peptide endothelin-1 (ET-1), is present in insulin-resistant states and is an important factor promoting the development of cardiovascular complications in patients with insulin resistance. The aim of...
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