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Open Archive: Publications from Karolinska Institutet
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7523 Publications
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  • Bioactive peptides and proteins in disease

    Refai, Essam (2004)
    Regulatory peptides and marker proteins are important to study in order to understand disease mechanisms. This applies of course also to our common diseases where all relationships are not yet known. Cancer and diabetes are two such complex diseases that affect hundreds of millions of people worldwide. This thesis addresses particular aspects of these two diseases, regarding one regulatory peptide (VIP, vasoactive intestinal polypeptide) that may be useful for tumor tracing ...

    Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line

    Sandberg, Malin (2005)
    The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. Neuropathological findings characteristic for prion diseases are spongiform degeneration, astrogliosis and neuronal cell death. Loss of presynaptic ...

    Inflammatory proteins in the CNS-relation to Alzheimers disease

    Lindberg, Catharina (2005)
    Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated astrocytes and microglia surrounding the amyloid plaques represent evidence for neuroinflammation in the AD brain. The reactive glial cells produce cytokines such as interleukin (IL)-1, IL-6 and tumour necrosis factor-alpha (TNFalpha), as well as chemokin...

    Rectal cancer survivorship : work loss and long-term morbidity

    Chen, Lingjing (2017)
    In the last few decades, due to early detection and advances in treatments, rectal cancer survival has been improved significantly. Meanwhile, rectal cancer survivors and health practitioners are facing more challenges arising from the disease, in terms of survivors’ longterm morbidity and work ability. The general aims of the register-based doctoral projects therefore include: 1). to evaluate the short- and long-term work loss in incident relapse-free rectal cancer survivors, ...

    Lifestyle, dietary and environmental exposures in infancy and the development of allergic sensitization

    Fagerstedt Nilsson, Sara (2017)
    Allergy related diseases have increased in the Western world, affecting nearly half of the children. Lifestyle, dietary and environmental changes are thought to be important for disease risk and disease development. The aim of the prospective ALADDIN (Assessment of Lifestyle and Allergic Disease During INfancy) cohort is to study how lifestyle and environmental factors during pregnancy and early childhood affect the development of allergic disease in children. The aim of this thesis was...
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