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Name
Access to Research and Communications Annals
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Institutional Repository
Items
526 Publications
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OpenAIRE 3.0 (OA, funding)
OAI-PMH
http://arca.igc.gulbenkian.pt/oai/openaire
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  • Localized contacts between hosts reduce pathogen diversity

    Nunes, A.; da Gama, M. M. T.; Gomes, M. G. M. (2006)
    Projects: FCT | POCTI/MAT/47510/2002 (47510), FCT | POCTI/ESP/44511/2002 (44511)
    We investigate the dynamics of a simple epidemiological model for the invasion by a pathogen strain of a population where another strain circulates. We assume that reinfection by the same strain is possible but occurs at a reduced rate due to acquired immunity. The rate of reinfection by a distinct strain is also reduced due to cross-immunity. Individual based simulations of this model on a 'small-world' network show that the proportion of local contacts in the host contact network structure ...

    Tissue damage control in disease tolerance

    Soares, Miguel P; Gozzelino, Raffaella; Weis, Sebastian (2014)
    Projects: FCT | SFRH/BPD/44256/2008 (SFRH/BPD/44256/2008), FCT | PTDC/SAU-TOX/116627/2010 (116627), EC | DAMAGECONTROL (294709)
    The deposited article is a prost-print version. This publication hasn't any creative commons license associated. This deposit is composed by the main article, and it hasn't any supplementary materials associated. Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose her...

    Dynamics and control of measles in Portugal: Accessing the impact of anticipating the age for the first dose of MMR from 15 to 12 months of age

    Paulo, A. C.; Gomes, M. C.; Gomes, M. G. M. (2008)
    Projects: FCT | SFRH/BPD/7160/2001 (SFRH/BPD/7160/2001)
    The all-time low incidence of measles in Portugal in the recent years, raises questions regarding whether the disease has been eliminated, the role of recent control measures, and the epidemiological consequences of the rise in the proportion of newborns to vaccinated mothers, as opposed to those born to mothers who acquired immunity by natural infection. We estimate the vaccination coverage against measles in Portugal. on a cohort-by-cohort basis, and incorporate this information into an age...

    The crystal structure of the Escherichia coli autoinducer-2 processing protein protein LsrF

    Diaz, Z.; Xavier, KB.; Miller, ST. (2009)
    Many bacteria produce and respond to the quorum sensing signal autoinducer-2 (AI-2). Escherichia coli and Salmonella typhimurium are among the species with the lsr operon, an operon containing AI-2 transport and processing genes that are up regulated in response to AI-2. One of the Lsr proteins, LsrF, has been implicated in processing the phosphorylated form of AI-2. Here, we present the structure of LsrF, unliganded and in complex with two phospho-AI-2 analogues, ribose-5-phosphate and ribul...

    The making of gametes in higher plants

    Boavida, L.; Becker, J.D.; Feijó, J.A. (2005)
    Projects: FCT | POCTI/BCI/41725/2001 (41725)
    Higher plants have evolved to be one of the predominant life forms on this planet. A great deal of this evolutionary success relies in a very short gametophytic phase which underlies the sexual reproduction cycle. Sexual plant reproduction takes place in special organs of the flower. In most species the processes of gametogenesis, pollination, syngamy and embryogenesis are sequentially coordinated to give rise to a functional seed in a matter of few weeks. Any of these processes is so intrica...
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