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Name
ECNIS-NIOM Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility)
Type
Institutional Repository
Items
700 Publications
Compatibility
OpenAIRE Basic (DRIVER OA)
OAI-PMH
http://ecnis.openrepository.com/ecnis/oai/request
More information
Detailed data provider information (OpenDOAR)

 

  • Oxidative damage.

    Olinski, Ryszard; Loft, Steffen; Nair, Urmila; Nair, Jagadeesan (2006)
    3.1. Biomarkers of DNA base oxidation 3.2. Lipid peroxidation induced DNA damage Free radical attack upon DNA generates, among other changes, modified bases. The amount of 8-oxo-7,8-dihydroguanine, one of the most critical lesions in human lymphocytes, was found to be 1.2/106. Gua by a mass spectrometric approach. Spurious oxidation occurring during sample preparation is the major problem in measurement of oxidised bases in DNA. Exposure to ambient air particles and benzene is as...

    Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.

    Manuguerra, M.; Matullo, G.; Veglia, F.; Autrup, H.; Dunning, A.M.; Garte, S.; Gormally, E.; Malaveille, C.; Guarrera, S.; Polidoro, S.; Saletta, F.; Peluso, M.; Airoldi, L.; Overvad, K.; Raaschou-Nielsen, O.;... (2007)
    It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 ...

    Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

    Howells, Lynne M.; Moiseeva, Elena P.; Neal, Christopher P.; Foreman, Bethany E.; Andreadi, Catherine K.; Sun, Yi-yang; Hudson, E. Ann; Manson, Margaret M (2007)
    There is growing interest in the ability of phytochemicals to prevent chronic diseases, such as cancer and heart disease. However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans. In order to optimize the design of chemopreventive treatment, it is important to determine which of the many reported mechanisms of action are clinically relevant. In this revie...

    Selenoproteins and selenium speciation in food.

    Hoac, T.; Lundh, T.; Onning, G.; Akesson, B. (2012)
    Different forms of selenium may have varying bioavailability and may also have different effects on body physiology. For these reasons we have studied the occurrence of different forms of selenium in some foods. The pattern of soluble selenium compounds in different species of fish varied markedly as studied by size-exclusion chromatography coupled to ICP-MS or GFAAS. Most flatfish contained mainly low-molecular-weight selenium compounds while other fish species contained more protein-bound s...

    Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes.

    Sabbioni, Gabriele; Jones, Christopher R.; Sepai, Ovnair; Hirvonen, Ari; Norppa, Hannu; Järventaus, Hilkka; Glatt, Hansruedi; Pomplun, Doreen; Yan, Huifang; Brooks, Lance R.; Warren, Sarah H.; Demarini, David M.; Liu, Yu-Ying (2006)
    Biomarkers of exposure & effect: validationBiomarker: hemoglobin (Hb) adductsExposure/effect represented: Nitrotoluenes, such as 2-nitrotoluene, 2,4-dinitrotoluene (24DNT), and 26DNTStudy type (in vitro, animals, humans): humansStudy design (if human):case-controlStudy size (if human): exposed (n = 104), control (n = 72)Mode of exposure (if in vivo) (acute, chronic, root of exposure):air monitoringMethod of analysis: questionnairesSensitivity (LOD):Specificity:Accuracy:Intraday precision: In...
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