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Name
ECNIS-NIOM Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility)
Type
Institutional Repository
Items
689 Publications
Compatibility
OpenAIRE Basic (DRIVER OA)
OAI-PMH
http://ecnis.openrepository.com/ecnis/oai/request
More information
Detailed data provider information (OpenDOAR)

 

  • Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells.

    Buterin, Tonko; Koch, Caroline; Naegeli, Hanspeter (2006)
    KEYWORDS - CLASSIFICATION: agonists;Antineoplastic Agents;Breast Neoplasms;Cell Line,Tumor;drug therapy;Environmental Pollutants;Estradiol;Estrogens;Estrogens,Non-Steroidal;genetics;Gene Expression Profiling;Genistein;Humans;metabolism;mechanisms of carcinogenesis;Oligonucleotide Array Sequence Analysis;pharmacology;Phenols;Polychlorinated Biphenyls;Research;Toxicology;Tumor Markers,Biological. Estrogen receptors display high levels of promiscuity in accommodating a wide range of ligand st...

    Validation of biomarkers for the study of environmental carcinogens: a review.

    Gallo, Valentina; Khan, Aneire; Gonzales, Carlos; Phillips, David H.; Schoket, Bernadette; Gyorffy, Erika; Anna, Livia; Kovacs, Katalin; Moller, Peter; Loft, Steffen; Kyrtopoulos, Soterios; Matullo, Giuseppe; Vineis, Paolo (2008)
    There is a need for validation of biomarkers. Our aim is to review published work on the validation of selected biomarkers: bulky DNA adducts, N-nitroso compounds, 1-hydroxypyrene, and oxidative damage to DNA. A systematic literature search in PubMed was performed. Information on the variability and reliability of the laboratory tests used for biomarkers measurements was collected. For the evaluation of the evidence on validation we referred to the ACCE criteria. Little is known about intrain...

    Oxidative damage.

    Olinski, Ryszard; Loft, Steffen; Nair, Urmila; Nair, Jagadeesan (2006)
    3.1. Biomarkers of DNA base oxidation 3.2. Lipid peroxidation induced DNA damage Free radical attack upon DNA generates, among other changes, modified bases. The amount of 8-oxo-7,8-dihydroguanine, one of the most critical lesions in human lymphocytes, was found to be 1.2/106. Gua by a mass spectrometric approach. Spurious oxidation occurring during sample preparation is the major problem in measurement of oxidised bases in DNA. Exposure to ambient air particles and benzene is as...

    Balkan endemic nephropathy: role of ochratoxins A through biomarkers.

    Castegnaro, Marcel; Canadas, Delphine; Vrabcheva, Terry; Petkova-Bocharova, Theodora; Chernozemsky, Ivan N.; Pfohl-Leszkowicz, Annie (2006)
    Biomarker: DNA adductsExposure/effect represented: ochratoxin A (OTA) / DNA damageStudy type: humans, Dark Agouti ratsStudy design: cross-sectional studyStudy size: 16 healthy volunteersAnalytical technique: OTA food intake, OTA blood concentration and urinary OTA excretion; DNA adducts in kidney of male and female rats using post labellingTissue/biological material/sample size: human blood and urine; Dark Agouti rat blood, urine and kidneyImpact on outcome (including dose-response): Average...

    Selenoproteins and selenium speciation in food.

    Hoac, T.; Lundh, T.; Onning, G.; Akesson, B. (2012)
    Different forms of selenium may have varying bioavailability and may also have different effects on body physiology. For these reasons we have studied the occurrence of different forms of selenium in some foods. The pattern of soluble selenium compounds in different species of fish varied markedly as studied by size-exclusion chromatography coupled to ICP-MS or GFAAS. Most flatfish contained mainly low-molecular-weight selenium compounds while other fish species contained more protein-bound s...
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