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ECNIS-NIOM Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility)
Institutional Repository
687 Publications
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Detailed data provider information (OpenDOAR)


  • In vitro mammalian metabolism of the mitosis inhibitor zoxamide and the relationship to its in vitro toxicity.

    Oesch, F.; Metzler, M.; Fabian, E.; Kamp, H.; Bernshausen, T.; Damm, G.; Triebel, S.; Dohmer, J.; Landsiedel, R.; Van Ravenzwaay, B. (2010)
    The in vitro mammalian metabolism of the fungicide zoxamide is related to its in vitro mammalian toxicity. After incubation of zoxamide with rat liver microsomes leading to practically 100% metabolism (mostly hydroxylated zoxamide), the cytotoxicity (methyl thiazole tetrazolium (MTT) test) and the mitosis-inhibiting potential (shown by cell count and by cell cycle analysis) for V79 were not distinguishable from those of zoxamide, demonstrating that the hydroxylation of zoxamide did not change...

    New aspects on mechanisms of chemical carcinogenesis: emphasis on species and gender/sex differences and developmental/aging determinants.

    Oesch, Franz; Dietrich, Cornelia; Naegeli, Hanspeter; Schwarz, Michael; van der Horst, Gijsbertus; Zanger, Ulrich; Oesch, Barbara; Weiss, Carsten (2008)

    Oxidative damage to DNA and antioxidant status in aging and age-related diseases.

    Olinski, Ryszard; Siomek, Agnieszka; Rozalski, Rafal; Gackowski, Daniel; Foksinski, Marek; Guz, Jolanta; Dziaman, Tomasz; Szpila, Anna; Tudek, Barbara (2007)
    Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegen...

    Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain).

    Zamora-Ros, Raul; Andres-Lacueva, Cristina; Lamuela-Raventos, Rosa M.; Berenguer, Toni; Jakszyn, Paula; Barricarte, Aurelio; Ardanaz, Eva; Amiano, Pilar; Dorronsoro, Miren; Larranaga, Nerea; Martinez, Carmen; Sanchez, Maria J.; Navarro, Carmen; Chirlaque, Maria D.; Tormo, Maria J.;... (2010)
    BACKGROUND: Epidemiologic studies have suggested associations between flavonoid intake and health benefits. Traditional Mediterranean diets consist of a high consumption of plant products rich in flavonoids. OBJECTIVE: This study estimates dietary flavonoid intake and main food sources in a Mediterranean population (Spanish adults). DESIGN: The study included 40,683 subjects aged 35 to 64 years from northern and southern regions of Spain who were included in the European Prospective Investiga...
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