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Name
Helmholtz Zentrum für Infektionsforschung Repository
Type
Institutional Repository
Items
2274 Publications
Compatibility
OpenAIRE 3.0 (OA, funding)
OAI-PMH
http://hzi.openrepository.com/hzi-oai/request
More information
Detailed data provider information (OpenDOAR)

 

  • High efficient adenoviral-mediated VEGF and Ang-1 gene delivery into osteogenically differentiated human mesenchymal stem cells.

    Klöpper, Jonas; Lindenmaier, Werner; Fiedler, Ulrike; Mehlhorn, Alexander; Stark, G Björn; Finkenzeller, Günter (2008)
    Survival of ex vivo constructed tissues after transplantation is limited by insufficient oxygen and nutrient supply. Therefore, strategies aiming at improvement of neovascularization of engineered tissues are a key issue in tissue engineering applications. This in vitro study aimed at exploring the usability of osteogenically differentiated human mesenchymal stem cells (MSCs) as carriers of the angiogenic growth factor genes vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1)...

    Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants.

    Sunderhaus, Stephanie; Dudkina, Natalya V; Jänsch, Lothar; Klodmann, Jennifer; Heinemeyer, Jesco; Perales, Mariano; Zabaleta, Eduardo; Boekema, Egbert J; Braun, Hans-Peter (2006)
    Complex I of Arabidopsis includes five structurally related subunits representing gamma-type carbonic anhydrases termed CA1, CA2, CA3, CAL1, and CAL2. The position of these subunits within complex I was investigated. Direct analysis of isolated subcomplexes of complex I by liquid chromatography linked to tandem mass spectrometry allowed the assignment of the CA subunits to the membrane arm of complex I. Carbonate extraction experiments revealed that CA2 is an integral membrane protein that is...

    Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.

    Abdelsamie, Ahmed S; Bey, Emmanuel; Hanke, Nina; Empting, Martin; Hartmann, Rolf W; Frotscher, Martin (2014)
    Estradiol is the most potent estrogen in humans. It is known to be involved in the development and proliferation of estrogen dependent diseases such as breast cancer and endometriosis. The last step of its biosynthesis is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β- HSD1) which consequently is a promising target for the treatment of these diseases. Recently, we reported on bicyclic substituted hydroxyphenylmethanones as potent inhibitors of 17β-HSD1. The present study focuses on...

    Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin.

    Diestel, Randi; Irschik, Herbert; Jansen, Rolf; Khalil, Mohammed W; Reichenbach, Hans; Sasse, Florenz (2009)
    Chivosazoles A and F, isolated from Sorangium cellulosum, showed high antiproliferative activity with different mammalian cell lines including human cancer cells. The chivosazoles caused a delay in G2/M phase of the cell cycle, and treated cells often contained two nuclei. By labeling F-actin it was shown that the actin cytoskeleton of the cells starts to break down after a few minutes of treatment. In vitro polymerization assays with purified G-actin revealed that the chivosazoles inhibit ac...
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