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  • Assembly and arrangement of the type three secretion system of "yersinia enterocolitica"

    Amstutz, Marlise (2014)
    The type three secretion system (T3SS) is a bacterial weapon found in many Gram-negative bacteria. It consists out of a needle like structure called injectisome, which enables bacteria to inject effector proteins into eukaryotic cells. The injectisome is a very complex molecular machine, inserted in the inner and outer bacteria membrane, passing the periplasm with the peptidoglycan layer. We used an approach with fluorescent hybrid proteins to study the assembly order of the injectisome in Ye...

    Status and new beginnings : archaeozoological research into the Early Medieval rural settlements of northwest Switzerland

    Frosdick, Richard (2014)
    The Early Medieval period in Europe sees the start of the formation of the land boundaries which are today considered modern Europe. This is a period of great change throughout Europe. Most significantly the Roman Empire is collapsing (Drack, 1979). The ‘Romanisation’ of the region is heavily studied and relatively well understood as it appears to be for the rest of Europe (Flutsch et al. 2002). However the withdrawal of the roman administration of the region is less well studied, until ...

    CF3 Substitution of [Cu(P^P)(bpy)][PF6] complexes: Effects on Photophysical Properties and Light-emitting Electrochemical Cell Performance

    Keller, Sarah; Brunner, Fabian; Junquera-Hernández, José M.; Pertegás, Antonio; La-Placa, Maria‐Grazia; Prescimone, Alessandro; Constable, Edwin C.; Bolink, Henk J.; Orti, Enrique; Housecroft, Catherine E. (2018)
    We report [Cu(P^P)(N^N)][PF 6 ] complexes with P^P = bis(2-(diphenylphosphino)phenyl)ether (POP) or 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (xantphos), N^N = CF 3 -substituted 2,2'-bipyridines (6,6'-(CF 3 ) 2 bpy, 6-CF 3 bpy, 5,5'-(CF 3 ) 2 bpy, 4,4'-(CF 3 ) 2 bpy, 6,6'-Me 2 -4,4'-(CF 3 ) 2 bpy). We present the effects of CF 3 substitution on structures, and electrochemical and photophysical properties. The HOMO–LUMO gap is tuned by the N^N ligand; the largest redshift in the MLCT ban...

    Functional organization of the human anterior insular cortex

    Mutschler, Isabella; Wieckhorst, Birgit; Kowalevski, Sandra; Derix, Johanna; Wentlandt, Johanna; Schulze-Bonhage, Andreas; Ball, Tonio (2009)
    The human insular cortex is involved in a wide range of functions including motor control, language, and homeostatic regulation. Little is known, however, how these functions are topographically organized in the insular cortex and how they are functionally related to the amygdala, which is anatomically connected to the insular cortex. We have investigated these questions by conducting an activation likelihood estimate (ALE) meta-analysis of previously published neuroimaging studies reporting ...

    Systems genomics analysis of complex cognitive traits

    Freytag, Virginie (2017)
    The study of the genetic underpinnings of human cognitive traits is deemed an important tool to increase our understanding of molecular processes related to physiological and pathological cognitive functioning. The polygenic architecture of such complex traits implies that multiple naturally occurring genetic variations, each of small effect size, are likely to influence jointly the biological processes underlying cognitive ability. Genetic association results are yet devoid of biological con...
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