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  • Expression and localization of Ski determine cell type-specific TGFbeta signaling effects on the cell cycle

    Jacob, C.; Grabner, H.; Atanasoski, S.; Suter, U. (2008)
    Transforming growth factor beta (TGFbeta) promotes epithelial cell differentiation but induces Schwann cell proliferation. We show that the protooncogene Ski (Sloan-Kettering viral oncogene homologue) is an important regulator of these effects. TGFbeta down-regulates Ski in epithelial cells but not in Schwann cells. In Schwann cells but not in epithelial cells, retinoblastoma protein (Rb) is up-regulated by TGFbeta. Additionally, both Ski and Rb move to the cytoplasm, where they partially col...

    The effect of an extract from mycelium of "Penicillium chrysogenum" on plant-pathogen interactions and characterisation of elicitors in this extract

    Thürig, Barbara (2004)
    In agriculture, infection of plants with microorganisms including fungi, bacteria and viruses can cause high losses of yield. Apart from a broad spectrum of indirect and direct techniques to protect plants from damage, the concept of induced resistance provides a promising strategy for the control of diseases. Preliminary studies suggested that an aqueous extract from the dry mycelium of the non-pathogenic ascomycete Penicillium chrysogenum, further called ‘Pen’, can enhance resistance of man...

    Interactions of an antimicrobial reptaibol with amphiphilic block copolymers

    Haefele, Thomas Friedrich (2006)
    In this thesis the behavior of binary membranes from amphiphilic PMOXA-PDMSPMOXA triblock copolymers and the peptaibol alamethicin, an antimicrobial peptide, was investigated in the context of formation of novel biocomposite nanostructured materials. This task was achieved by employing monolayer and bilayer systems. Pure systems as well as mixtures of the individual materials were considered. The properties of mixed monolayers were studied by surface pressure-area isotherms and Brewster angle...

    Zinc-selective inhibition of the promiscuous bacterial amide-hydrolase DapE: implications of metal heterogeneity for evolution and antibiotic drug design

    Uda, Narasimha Rao; Upert, Grégory; Angelici, Gaetano; Nicolet, Stefan; Schmidt, Tobias; Schwede, Torsten; Creus, Marc (2014)
    The development of resistance to virtually all current antibiotics makes the discovery of new antimicrobial compounds with novel protein targets an urgent challenge. The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) is an essential metallo-enzyme for growth and proliferation in many bacteria, acting in the desuccinylation of N-succinyl-l,l-diaminopimelic acid (SDAP) in a late stage of the anabolic pathway towards both lysine and a crucial building block of the peptidogl...
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