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Institutional Repository
1838 Publications
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  • Psychiatric and physical comorbidity in adults with autism spectrum disorder

    O'Rourke, Linda (2016)
    Autism spectrum disorder (ASD) is a highly impairing neurodevelopmental condition, manifesting in childhood and continuing into adult life. Comorbid psychiatric and physical illness lends considerable increased mortality to the condition. An increased awareness of comorbid conditions in adults with normal IQ ASD could improve diagnostic formulation, facilitate targeted treatments and improve psychosocial outcomes. This study examines the prevalence of comorbid psychiatric and physical illn...

    Curriculum reform: a narrated journey.

    MacCarrick, Geraldine (2009)
    OBJECTIVES: Curriculum reform poses significant challenges for medical schools across the globe. Understanding the medical educator's personal and lived experience of curriculum change is paramount. This paper illustrates the use of narrative inquiry as a means of exploring the author's own evolving professional identity as a medical educator engaged in planning and leading curriculum reform and in understanding the meanings she and other medical educators attribute to their roles as agents o...

    The Molecular Epidemiology of Resistance in Cefotaximase-Producing Escherichia coli Clinical Isolates from Dublin, Ireland.

    Burke, Liam; Humphreys, Hilary; Fitzgerald-Hughes, Deirdre (2016)
    In view of continued high clinical prevalence of infections involving extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, this study sought to characterise the blaCTX-M genes, their associated mobile genetic elements and the integrons present in 100 ESBL-producing E. coli isolates collected in a Dublin hospital and associated community healthcare facilities. Polymerase chain reaction (PCR) mapping and sequencing was used to detect blaCTX-M alleles, their associated insertion sequ...

    Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability

    Prydderch, Hannah; Haib, Annette; Spulak, Marcel; Quilty, Brid; Kummerer, Klaus; Heise, Andreas; Gathergood, Nicholas (2017)
    A series of ten ionic liquids (ILs) was synthesised from the renewable resource mandelic acid. The ILs showed low antimicrobial activity towards the thirteen bacterial and twelve fungal strains they were screened against. A general trend of increasing bacterial toxicity in the order methyl ester < ethyl ester < n-butyl ester/amide was observed. IL biodegradability was evaluated using the Closed Bottle test (OECD 301D). Biodegradation increased in the order of increasing alkyl chain length for...

    Hypothesis-Driven Proteomic Data-Analysis of Plasma from Subjects in the At-Risk Mental State

    Sabherwal, Sophie (2017)
    Strong evidence now supports an association between systemic abnormalities and schizophrenia pathology. Furthermore, the clinical outcome in schizophrenia is significantly improved by early identification and treatment. These factors are driving the search for blood-based biomarkers for the disorder. Promising biomarker findings are hampered however by a relative lack of studies in prodromal psychosis, such as the at-risk mental state (ARMS). Poor replication of findings, particularly across ...
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