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Institutional Repository
1531 Publications
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  • Global HIV / AIDS initiatives and coordination, reporting and evaluation of HIV/AIDS programmes.

    This policy brief describes the effectiveness of national and district level coordination structures and monitoring and evaluation systems in Zambia and the extent to which GHIs have engaged with these, and/or created new structures and systems for HIV/AIDS programmes. The overall study, whose fieldwork was conducted in 2007 and 2008, explored the effects of three GHIs on the Zambian health system: the Global Fund to fight AIDS, TB and Malaria (GFATM), the World Bank’s Multi-country AIDS Prog...

    Strategies for the Efficacy and Safety of Antiplatelet Drugs

    SUMMARY P2Y12 receptor antagonists including clopidogrel, prasugrel or ticagrelor in addition toaspirin are the standard of care for the treatment in acute coronary syndrome andpercutaneous coronary intervention. The benefit of this therapy is based on the balance between the reduction of ischaemic events and minimising bleeding risk. Therefore, it isimportant to have strategies to both ensure the optimal inhibition of the P2Y12 receptor andthe effective prevention and treatment of bleedin...

    The Use of Coercion in Clinical Mental Health Practice

    Background Coercive psychiatric treatment is one of the most controversial practices in medicine with some arguing that it is unfortunately necessary and others arguing that it is unjustified torture. Further research is required to inform clinical decision-making and service development. Objectives In study one, I aim to determine predictors and associations of coercion during admission. In study two, I aim to determine the impact of coercion during admission on outcomes one year af...

    A cluster randomised trial of the leg ulcer prevention programme (LUPP) in venous leg ulcer patients within an Irish Community Care setting.

    Objective: This purpose of this study was to determine the effects of a Leg Ulcer Prevention Programme (LUPP) on patient’s knowledge of, and attitudes and behaviours towards, leg ulcer prevention within the Irish community care setting. Method: The research design employed in this study was a multi-centre, open label, cluster, randomised controlled trial. Participants (average age 74.8 years) had attended the nurse-led clinic in the previous twelve months and had a history of venous leg ul...

    Use of Aliphatic and Aromatic Styryl Isoxazoles as Versatile Intermediates for the Synthesis of Peptidomimetics, Drug Molecules and Optically Active Building Blocks for Organic Synthesis

    The aim of the project is the development of novel MRI imaging agents for the early diagnosis of platelet-rich thrombi. These novel agents were designed to allow use of multiple reporting techniques such as MRI, UV-fluorescence, near IR fluorescence and to target the platelet specific integrin GPIIbIIIIa. Progress in the understanding of the central importance of platelets in cardiovascular disease, combined with the development of new classes of antiplatelet agents, has dramatically altered ...
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