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Erasmus University Institutional Repository
Institutional Repository
28029 Publications
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  • Surgery in Childhood

    Ende, E.D. (2006)
    textabstractThe aim of this thesis was to assess the management and treatment outcomes of surgery in childhood by comparing the results obtained in a specialized pediatric center and in a general teaching hospital. More precisely, we analyzed the distribution of common surgical diseases in childhood among pediatric university centers and general hospitals in the Netherlands. Furthermore, we explored several common surgical procedures in childhood by identifying the value of various noninvasiv...

    Thermografie en myocardischemie

    Hage, G.H. (1979)
    textabstractSinds chirurgische therapie bij coronairlijden wordt toegepast, is het steeds moeilijk geweest objectieve maatstaven te hanteren bij het beoordelen van de operatieresultaten. Veelal waren subjectieve pijnklachten van patiƫnten met ischemische hartziekten afgenomen, maar het bleef onbekend of ook werkelijk de ischemie van de hartspier verminderd was (22, 34, 80, 94, 96, 114, 128, 146, 155). In de loop der jaren is men over steeds meer objectieve beoordelingsmethoden gaan beschikken...

    Structure of the nuclear pore complex in mammalian cells. Two annular components.

    textabstractThe ultrastructure of the nuclear pore complex has been investigated in isolated nuclei of an in vitro cultured bovine liver cell line. In shadow-cast replicas of the surface of nuclei isolated in Tris buffer containing low K+ and Mg2+ concentrations (RSB) the rims of the pores appeared as annular projections with an outer diameter of 100 to 120 nm. When the nuclei were isolated in Tris buffer containing 0.1% Triton the projections were essentially lost, together with the outer me...

    Augmentation of protein production by a combination of the T7 RNA polymerase system and ubiquitin fusion: Overproduction of the human DNA repair protein, ERCC1, as a ubiquitin fusion protein in Escherichia coli.

    textabstractThis article presents the development of a set of new expression vectors for overproduction of proteins in Escherichia coli. The vectors, pETUBI-ES1, 2 and 3, allow in-frame cloning of any sequence with the ubiquitin gene driven by the strong T7f10 promoter. Combination of the T7 expression system with ubiquitin fusion appears to have a synergistic effect on protein overproduction. Large amounts of stable RNA are produced by T7 RNA polymerase, and fusion of ubiquitin to the N-term...

    Phase II study of neo-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resectable squamous cell carcinoma of the esophagus

    textabstractBACKGROUND: We have previously reported a favourable response rate in patients with advanced esophageal cancer after treatment with a biweekly regimen of paclitaxel and cisplatin. In this study we investigate the feasibility and efficacy of this regimen in a neo-adjuvant setting. PATIENTS AND METHODS: Patients with resectable squamous cell carcinoma of the esophagus received paclit-axel 180 mg/m(2) and cisplatin 60 mg/m(2) every 2 weeks. Patients received three courses and respond...
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