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1888 Publications
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  • Studio della partecipazione di cellule staminali mesenchimali umane (hu-MSCs) nei processi di riparazione conseguenti al danno miocardico acuto in topi Balb/c Athymic Nude-Fox1nu

    Cardio Vascular Diseases (CVD) are the most common causes of death worldwide and, among these, the acute myocardial infarction (AMI) represents the leading one. Studies comparing the regenerative capacity of distinct stem cells populations suggest that bone marrow mesenchymal stem cells (BM-MSCs) could be the most indicated cells for these purpose. They have a multi-lineage differentiation, an immunomodulatory and self-renewal capacity as well as a high proliferative ratio. 3x106 BM-MSCs i...

    Auto-assemblaggio di nano-sistemi catalitici a base di peptidi e nanoparticelle d'oro.

    The catalytic efficiency, mechanistic pathways, and structural complexity displayed by enzymes make them a tremendous source of inspiration for chemists involved in catalyst development[1, 2]. Nature has evolved enzymes as large multi-kilodalton complex structures in which even units that are remote from the actual active site may profoundly affect the activity of the enzyme[3]. The much lower complexity of artificial enzyme mimics may be an important reason for their typical modest performan...

    Statistical Reconciliation of Time Series. Movement Preservation vs. a Data Based Procedure.

    Most of the data obtained by statistical agencies have to be adjusted, corrected or somehow processed by statisticians in order to arrive at useful, consistent and publishable values. When temporally and contemporaneously aggregated series are known, temporal (e.g., between quarterly and annual data) and contemporaneous (between the quarterly aggregate and the sum of its component series) discrepancies can be eliminated using various reconciliation procedures. In this paper we consider (i) an...

    G-quadruplexes in the HSV-1 and HHV-6 genomes as antiviral targets

    Guanine-rich nucleic acids can fold into G-quadruplexes, four-stranded secondary structures which are implicated in important regulatory functions at the genomic level in humans, prokaryotes and viruses. Because the herpes simplex virus-1 (HSV-1) genome is remarkably rich in guanines, we aimed at investigating both the presence of G-quadruplex forming sequences at the viral genome level and the possibility to target them with G-quadruplex ligands to obtain anti-HSV-1 effects with novel mechan...
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