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42406 Publications
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  • Laparoscopic subperitoneal injection of chemo-loaded particles lowers tumor growth on a rabbit model of peritoneal carcinomatosis

    Fazel, Afshin; Namur, Julien; Ghegediban, Saida-Homayra; D'Inca, Hadrian; Wassef, Michel; Moine, Laurence; Laurent, Alexandre (2017)
    The purpose of our study was to assess the effect of controlled-release chemotherapy on the growth and viability of peritoneal carcinomatosis treated by subperitoneal injection in a rabbit VX2 model. A model of peritoneal carcinomatosis was created by laparoscopic injection of VX2 tumor in the left and right broad ligaments of 12 White New Zealand rabbits. At day 12, each tumor was randomly treated with a peritumoral injection of 0.5 mL microspheres loaded with doxorubicin (DEM-DOX) or unload...

    Quelles perspectives pour les politiques agricoles ?

    Hervieu, B.; Guyomard, Hervé; Institut National Agronomique Paris Grignon; University of Tokyo (2001)
    Alors que le secteur agricole s'est banalisé parmi d'autres industries, en particulier dans le cadre du commerce international, il semblerait logique que le rôle de l’état en ce secteur perde de sa spécificité. Sont recensées les spécificités qui font que L’État doit jouer un rôle dans les politiques agricoles et alimentaires, même si les arguments traditionnels pour justifier une intervention aussi massive sur les marchés que celle observée en Europe sont de moins en moins viables. Une révis...

    Arabidopsis seed secrets unravelled after a decade of genetic and omics-driven research

    North, Helen; Baud, Sebastien; Debeaujon, Isabelle; Dubos, Christian; Dubreucq, Bertrand; Grappin, Philippe; Jullien, Marc; Lepiniec, Loic; Marion-Poll, Annie; Miquel, Martine; Rajjou, Loïc; Routaboul, Jean-Marc; Caboche, Michel (2010)
    P>Seeds play a fundamental role in colonization of the environment by spermatophytes, and seeds harvested from crops are the main food source for human beings. Knowledge of seed biology is therefore important for both fundamental and applied issues. This review on seed biology illustrates the important progress made in the field of Arabidopsis seed research over the last decade. Access to 'omics' tools, including the inventory of genes deduced from sequencing of the Arabidopsis genome, has sp...

    Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model

    Crassous, Pierre-Antoine; Couloubaly, Samba; Huang, Can; Zhou, Zongmin; Baskaran, Padmamalini; Kim, David D.; Papapetropoulos, Andreas; Fioramonti, Xavier; Durán, Walter N. (2012)
    Nitric oxide (NO) by activating soluble guanylyl cyclase (sGC) is involved in vascular homeostasis via induction of smooth muscle relaxation. In cardiovascular diseases (CVDs), endothelial dysfunction with altered vascular reactivity is mostly attributed to decreased NO bioavailability via oxidative stress. However, in several studies, relaxation to NO is only partially restored by exogenous NO donors, suggesting sGC impairment. Conflicting results have been reported regarding the nature of t...

    Natural variations of the 13C/12C signature of leaf nocturnal respiration in Fagus Sylvatica branches related to previous day photosynthesis

    Gentsch, Lydia; Sturm, Patrick; Wingate, Lisa; Ogée, Jérôme; Siegwolf, Rolf; Hammerle, Albin; Plüss, Peter; Baur, Thomas; Barthel, Matthias; Buchmann, Nina; Knohl, Alexander (2013)
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