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University of Birmingham Research Archive, E-prints Repository
Institutional Repository
911 Publications
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  • What was the programme theory of New Labour’s health system reforms?

    Powell, Martin; Millar, Ross; Dixon, Anna (2012)
    To examine whether the Health System Reforms delivered the promise of being a coherent and mutually supporting reform programme; to identify the underlying programme theory of the reform programme; to reflect on whether lessons have been learned. Documentary analysis mapping the implicit and explicit programme theories about how the reforms intended to achieve its goals and outcomes. Semi-structured interviews with policy-makers to further understand the programme theory. The Health...

    Foundations of character: methodological aspects of a study of character development in three- to six-year-old children with a focus on sharing behaviours

    Arthur, James; Powell, Sacha; Lin, Hsing-Chiung (2012)
    This article focuses on methodological issues arising in a study of character development, using illustrations of ‘sharing behaviours.’ Based primarily in six early years settings in southeast England the research records naturalistic observations of peer interactions for 55 children aged three to six years. Applying grounded theory to the processes of observing, analysing and interpreting evidence required a cautious and collectively reflective approach. The methodology sought to moderate th...

    Mortality study of 18 000 patients treated with omeprazole.

    Bateman, D.N.; Colin-Jones, D.; Hartz, S.; Langman, M.; Logan, R.F.; Mant, J.W.F.; Murphy, M; Paterson, K.R.; Rowsell, R.; Thomes, S. (2002)
    Background: The long term safety of potent gastric acid suppressive therapy has yet to be established. Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the UK National Health Service Central Registers in 17 936 patients prescribed omeprazole in 1993–1995. Death rates were compared with general population rates. Results: Records of 17 489 patients (97.5%) were examined. A total of 1...

    SLoMo: automated site localization of modifications from ETD/ECD mass spectra

    Bailey, Christopher M; Sweet, Steve M M; Cunningham, Debbie L; Zeller, Martin; Heath, John K; Cooper, Helen J. (2009)
    Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present an algorithm, SLoMo (Site Localization of Modifications), which extends this capability to ETD/ECD mass spectra. Furthermore, SLoMo caters for both high and low resolution data and allows for site-localization of any UniMod post-translational modification. SLoMo accepts input data from a variety of formats (e.g., Sequest, OMSSA). We val...

    Hot Electron Capture Dissociation Distinguishes Leucine from Isoleucine in a Novel Hemoglobin Variant, Hb Askew, β54(D5)Val→Ile

    Williams, Jonathan P.; Creese, Andrew J.; Roper, David R.; Green, Brian N.; Cooper, Helen J. (2009)
    Population migration has led to the global dispersion of human hemoglobinopathies and has precipitated a need for their identification. An effective mass spectrometry-based procedure involves analysis of the intact α- and β-globin chains to determine their mass, followed by location of the variant amino acid residue by direct analysis of the enzymatically digested chains and low-energy collision induced dissociation of the variant peptide. Using this procedure, a variant was identified as eit...
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