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Name
Nature Precedings
Type
Thematic Repository
Items
2603 Publications
Compatibility
OpenAIRE Basic (DRIVER OA)
OAI-PMH
http://precedings.nature.com/oai2
More information
Detailed data provider information (OpenDOAR)

 

  • Protein folding disorders: Toward a basic biological paradigm

    Rodrick Wallace (2010)
    Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a cognitive paradigm for protein folding regulation will be needed for understanding the etiology, prevention, and treatment of these diseases.

    (Corrected) Osmotic stress and water isotope effects in kinesin-1 gliding motility assays

    Steven J. Koch; Andy Maloney; Lawrence J. Herskowitz (2010)
    The osmotic pressure and kinetic properties of water play important roles in biomolecular interactions. As pointed out by Parsegian, Rand, and Rau, these crucial roles are often overlooked[1]. In some fields, osmotic stress and isotope effects have been exploited for probing the role water plays in binding interactions of biomolecules. To our knowledge, there have been no studies of osmotic stress and water isotope effects for kinesin, and only a handful for myosin. We're currently u...

    Without magic bullets: the biological basis for public health interventions against protein folding disorders

    Rodrick Wallace (2010)
    Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter disease course. The design of individual or population level interventions will likely require a deeper understanding of protein folding and its regulation than currently provided by contemporary 'physics' or culture-bound medical m...

    In silico analysis for the presence of HARDY an Arabidopsis drought tolerance DNA binding transcription factor product in chromosome 6 of Sorghum bicolor genome

    Arun K. Shanker; M Maheswari; S K. Yadav; B Ventateswarlu (2009)
    Expression of the Arabidopsis HARDY (hrd) DNA binding transcription factor (555 bp present on chromosome 2) has been shown to increase WUE in rice by Karaba et al 2007 (PNAS, 104:15270–15275). We conducted a detail analysis of the complete sorghum genome for the similarity/presence of either DNA, mRNA or protein product of the Arabidopsis HARDY (hrd) DNA binding transcription factor (555 bp present on chromosome 2). Chromosome 6 showed a sequence match of 61.5 percent positive between ...

    Formal Systems Architectures for Biology

    Bradly Alicea (2011)
    When the word "systems" is used in systems biology, it invokes a variety of assumptions about what defines the subject under investigation, which in turn can lead to divergent research outcomes. We will take the position that systems are defined by their potential organizing and "control" mechanisms, which distinguishes complex, living systems from a primordial soup. This will be accomplished by defining and investigating three interesting control motifs in biolo...
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