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Nature Precedings
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3209 Publications
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  • Mining Co-expression Graphs: Applications to MicroRNA Regulation and Disease Analysis

    Malay Bhattacharyya (2012)
    MicroRNAs (miRNAs) are known to translationally repress or post-transcriptionally regulate mRNAs and are responsible for many diseases. We are preparing a comprehensive framework of co-expression analysis to figure out co-expression, differential co-expression and co-expression dynamics within multiple phenotypes in expression profiles. The purpose is to elucidate the disease association of miRNAs via co-regulatory pattern analysis.

    CloVR-16S: Phylogenetic microbial community composition analysis based on 16S ribosomal RNA amplicon sequencing – standard operating procedure, version 1.0

    James R. White; Cesar Arze; Malcolm Matalka; The CloVR Team; Owen White; Samuel V. Angiuoli; W. Florian Fricke (2011)
    The CloVR-16S pipeline employs several well-known phylogenetic tools and protocols for the analysis of 16S rRNA sequence datasets: A) Mothur – a C++-based software package used for clustering 16S rRNA sequences into operational taxonomic units (OTUs). Mothur creates OTUs using a matrix that describes pairwise distances between representative aligned sequences and subsequently estimates within-sample diversity (alpha diversity); B) The Ribosomal Database (RDP...

    Efficient Replication of Over 180 Genetic Associations with Self‐Reported Medical Data

    Joyce Y. Tung; Chuong B. Do; David A. Hinds; Amy K. Kiefer; J. Michael Macpherson; Arnab B. Chowdry; Uta Francke; Brian T. Naughton; Joanna L. Naughton; Anne Wojcicki; Nicholas Eriksson (2011)
    While the cost and speed of generating genomic data have come down dramatically in recent years, the slow pace of collecting medical data for large cohorts continues to hamper genetic research. Here we evaluate a novel online framework for amassing large amounts of medical information in a recontactable cohort by assessing our ability to replicate genetic associations using these data. Using web‐based questionnaires, we gathered self-reported data on 50 medical phenotypes from a genera...

    Ecological optimum of ectothermic organisms: static-dynamical approach

    Vladimir V. B. Verbitsky; Tamara T. I. Verbitskaya (2007)
    During 20th century the majority of researchers interpreted ecological optimum as a certain combination of ambient factors which is optimal for growth, existence and reproduction of an organism. However, it was revealed in many species, that the maximum rates of various processes in an organism are achieved at various combinations of values of different factors, and under variable regimes as opposite to constant regimes. One may state that there is no well defined general concept which takes ...

    Neural Information Processing: between synchrony and chaos

    Josep L. Rossello; Vincent Canals; Antoni Morro (2012)
    The brain is characterized by performing many different processing tasks ranging from elaborate processes such as pattern recognition, memory or decision-making to more simple functionalities such as linear filtering in image processing. Understanding the mechanisms by which the brain is able to produce such a different range of cortical operations remains a fundamental problem in neuroscience. Some recent empirical and theoretical results support the notion that the brain is naturally poised...
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