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  • Bortezomib, Doxorubicin, Cyclophosphamide, Dexamethasone Induction Followed by Stem Cell Transplantation for Primary Plasma Cell Leukemia: A Prospective Phase II Study of the Intergroupe Francophone du Myélome

    Royer , Bruno; Minvielle , Stéphane; Diouf , Momar; Roussel , Murielle; Karlin , Lionel; Hulin , Cyrille; Arnulf , Bertrand; Macro , Margaret; Cailleres , Sylvie; Brion , Annie; Brechignac , Sabine; Belhadj , Karim; Chretien , Marie Lorraine; Wetterwald , Marc; Chaleteix , Carine;... (2016)
    International audience; PURPOSE: Primary plasma cell leukemia (pPCL) is a rare and aggressive malignancy with a poor prognosis. With conventional chemotherapy, patients typically die within 1 year. In all but one of the retrospective studies reported to date, bortezomib and lenalidomide seem to improve survival. We conducted a prospective phase II trial in patients with pPCL to assess the efficacy of an alternate regimen that combines standard chemotherapy, a proteasome inhibitor, and high-do...

    Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance.

    Gaiarsa, Jean-Luc; Caillard, Olivier; Ben-Ari, Yehezkel (2002)
    International audience; Activity-dependent long-term changes in synaptic efficacy are thought to be important in learning, memory formation, neuronal development and pathological states of neuronal excitability in the CNS. For the past two decades, numerous studies have investigated long-term changes in synaptic efficacy at excitatory glutamatergic synapses. Although inhibitory synapses are essential for proper functioning of the neuronal network, attention has focused only recently on descri...

    High-resolution spectroscopy and preliminary global analysis of C–H stretching vibrations of C2H4 in the 3000 and 6000 cm−1 regions

    Loroño , Marcos; Boudon , Vincent; Loete , Michel; ROTGER , Maud; Bourgeois , Marie-Thérèse; Didriche , Kévin; Herman , Michel; Kapitanov , V. A.; Ponomarev , Yu.V.; Solodov , A. A.; Solodov , A. M.; Petrova , T. M. (2010)
    International audience; Ethylene (ethene, H2C=CH2) is a naturally occurring compound in ambient air that affects atmospheric chemistry and global climate. The C2H4 spectrum is available in databases only for the 1000 and 3000 cm−1 ranges. In this work, the ethylene absorption spectrum was measured in the 6030- 6250 cm−1 range with the use of a high resolution Bruker IFS 125HR Fourierspectrometer and a two-channel opto-acoustic spectrometer with a diode laser. As a secondary standard of wavele...

    Caractérisation mécanique de la paroi cellulaire des fibres végétales par Microscopie à Force Atomique

    Capron , Marie; Siniscalco , D; Ramonda , M.; Cuberes , T; Arinero , R.; Le Duigou , Antoine; Bourmaud , A.; Baley , C.; Arnould , Olivier (2017)
    International audience; The goal of this work is to demonstrate the advantages of nano-mechanical characterisations using an Atomic Force Microscope (AFM) for measuring (visco)elastic properties fields within the different cell wall layers of vegetal fibres (e.g., flax, wood). This tool particularly allows for measuring " in situ " properties at the submicrometre scales and for enhancing the occurrence, or not, of mechanical properties gradients within each cell wall layers. Practical applica...

    Modélisation des plis dans les membranes

    Diaby , Adama; Le Van , Anh; Wielgosz , Christian (2005)
    International audience; The problem of the wrinkling of the membranes is described in this paper within the total Lagrangian formulation. The membrane material obeys a prestressed hyperelastic constitutive equation and the finite elements are a 8-node quadrilateral and a 6-node triangular membrane element without flexural stiffness. The appearance of wrinkles in the membranes is treated by the bifurcation analysis without using any imperfection in the structure. The standard spherical arcleng...
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