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19433 Publications
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  • The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms

    Balbinot , Camille; Armant , Olivier; Elarouci , Nabila; Marisa , Laetitia; Martin , Elisabeth; De Clara , Etienne; Onea , Alina; Deschamps , Jacqueline; Beck , Felix; Freund , Jean-Noel; Duluc , Isabelle (2018)
    International audience; Developmental genes contribute to cancer, as reported for the homeobox gene Cdx2 playing a tumor suppressor role inthe gut. In this study, we show that human colon cancers exhibiting the highest reduction in CDX2 expression belong tothe serrated subtype with the worst evolution. In mice, mosaic knockout of Cdx2 in the adult intestinal epithelium inducesthe formation of imperfect gastric-type metaplastic lesions. The metaplastic knockout cells do not spontaneouslybecome...

    Unsupervised Models for White Matter Fiber-Bundles Analysis in Multiple Sclerosis

    Stamile , Claudio (2017)
    Diffusion Magnetic Resonance Imaging (dMRI) is a meaningful technique for white matter (WM) fiber-tracking and microstructural characterization of axonal/neuronal integrity and connectivity. By measuring water molecules motion in the three directions of space, numerous parametric maps can be reconstructed. Among these, fractional anisotropy (FA), mean diffusivity (MD), and axial (λa) and radial (λr) diffusivities have extensively been used to investigate brain diseases. Overall, these finding...

    Functional Principles of Posterior Septal Inputs to the Medial Habenula

    Otsu , Yo; Lecca , Salvatore; Pietrajtis , Katarzyna; Rousseau , Charly Vincent; Marcaggi , Païkan; Dugué , Guillaume Pierre; Mailhes-Hamon , Caroline; Mameli , Manuel; Diana , Marco Alberto (2018)
    International audience; The medial habenula (MHb) is an epithalamic hub contributing to expression and extinction of aversive states by bridging forebrain areas and midbrain monoaminergic centers. Although contradictory information exists regarding their synaptic properties, the physiology of the excitatory inputs to the MHb from the posterior septum remains elusive. Here, combining optogenetics-based mapping with ex vivo and in vivo physiology, we examine the synaptic properties of posterior...

    PD-L1 expression by tumor cell-lines: a predictive marker in melanoma

    Knol , Anne ,; Nguyen , Jean-Michel; Pandolfino , Marie-Christine; Denis , Marc ,; Khammari , Amir; Dréno , Brigitte (2018)
    International audience; Prognostic biomarkers for melanoma patients after lymph node resection are of clinical relevance and could thus enable the identification of patients who therefore would most benefit from adjuvant treatment. The aim of this work was to determine, using an in vitro model, whether immune-related biomarkers such as MHC-class I and II, melanoma associated antigens, IDO1 and PD-L1, could also be relevant to predict the risk of relapse of stage III melanoma patients after ly...

    Alcool : effets sur la santé

    Berr , Claudine; Clavel-Chapelon , Françoise; Dally , Sylvain; Daval , Jean-Luc; Fumeron , Frédéric; Girre , Catherine; Larroque , Catherine; Lucas , Danièle; Marques-Vidal , Pedro; Mathurin , Philippe; Nalpas , Bertrand; Rouach , Hélène (2001)
    Les effets de l’alcool sur la santé constituent aujourd’hui encore un lourdproblème de santé publique. Le Comité francais d’éducation pour la santé(CFES) estime à 5 millions le nombre de personnes ayant en France desproblèmes médicaux, psychologiques ou sociaux en relation avec une consommationexcessive d’alcool.L’intoxication alcoolique chronique est responsable d’un excès de morbiditéet de mortalité par cancer, hépatopathie, atteinte du système nerveux centralou périphérique, maladie cardio...
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