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Name
Publikationsserver der RWTH Aachen University
Type
Institutional Repository
Items
7390 Publications
Compatibility
OpenAIRE 2.0 (EC funding)
OAI-PMH
http://publications.rwth-aachen.de/oai2d
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  • Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose

    In the present thesis, intrinsic (ROS -> p53-activation / ROS -> mitochondrial apoptosis) and extrinsic (PI3K-Akt-Pathway) effects of the cytokine MIF (Macrophage Migration Inhibitory factor) have been examined and brought in connection with antiapoptotic and pro-proliferative effects. The functions as redox-active cytokine (redox acting cytokine = "Redoxkine"), which have been linked to anti-apoptotic characteristics of MIF could be confirmed and extended to cellular ROS models. In this cont...

    Multi-functional polymers from polyamines and functional five-membered cyclic carbonates

    This dissertation is concerned with the synthesis of functional polymers prepared by ring-opening reaction of functional five-membered cyclic carbonates with polyamines. The functionality of the polymers defines their properties and their application: multi-functional poly(ethylene imine)s for antimicrobial polymer and primer polymer for textile finishing were prepared. The main concept for the synthesis of multi-functional polymers comprises the coupling of two (functional) amines using a di...

    Unterschiedliche autonome Innervation in Pulmonalvene, linkem Vorhof und rechtem Vorhof : eine elektrophysiologische und pharmakologische Charakterisierung

    Ectopic beats originating in the pulmonary veins initiate atrial fibrillation. We evaluated the differential effects of combined locally increased neuronal tone an dilatation on effective refractory periods in pulmonray veins, right atrium and left atrium and correlated these functional properties to the underlying neuromorphology. Both raising intraatrial pressure and high intesity stimulation significantly decreased effective refractory period. In 36 Langendorff-perfused rabbit hearts effec...

    Measurement of the charged cosmic ray flux at solar minimum with the PERDaix detector

    This thesis deals with the development and data analysis of the PERDaix detector (Proton Electron Radiation Detector Aix-la-Chapelle). PERDaix is a particle detector with an geometrical acceptance of 33 cm2sr designed to measure the charged cosmic-ray flux with the help of three subdetectors: a spectrometer consisting of a permanentmagnet and eight tracker layers, a time-of-flight detector (TOF), and a transition radiation detector (TRD). The detector was flown on board a stratospheric resear...

    Ab initio investigations of π-conjugated-molecule-metal interfaces for molecular electronics and spintronics

    The demand for continuous miniaturization of electronic devices poses an enormous challenge to conventional electronics. Instead of further miniaturizing the already established silicon based technology beyond the nanoscale, designing electronic devices by the bottom-up strategy is a promising alternative. As the currently smallest imaginable parts for electronic devices, single atoms or molecules adsorbed on a substrate are the subject of research in the field of molecular electronics. In ad...
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