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Institutional Repository
11218 Publications
OpenAIRE 2.0+ (DRIVER OA, EC funding)
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  • Homotypic chondro-osseous differentiation, metastasis and osteotropism in Ewing Tumors

    Ewing tumors (ET) are highly malignant osteolytic bone tumors, characterized by early metastasis into lungs and bones. The bone-associated genes CHM1, DKK2 and ITM2A are highly overexpressed in this malignancy. The current study reveals the pro-metastatic gene DKK2 to be critically involved in ET pathology, especially in bone-associated tumor growth, osteolysis and metastasis, the latter being mediated by MMP1. Additionally, DKK2 prevents neuronal, but in parallel enhances chondro-osseous dif...

    The MAGIC Telescope

    The MAGIC Telescope is an Imaging Air Cherenkov Telescope (IACT) located on the Canary island of La Palma (28.80 N, 17.90 W), at the Roque de los Muchachos Observatory (2200 m above see level). The main goal of the experiment is to cover with high sensitivity the energy region between 10 GeV and 300 GeV in gamma-ray astronomy, which is inaccessible up to now, by lowering the threshold energy Eth as compared to the previous generation of IACTs. Observations in this new window of the electromag...

    A Systems View on Non-Normal Transient Growth in Thermoacoustics

    The present thesis investigates the dynamics of non-normal transient growth of a simple thermoacoustic system from a systems perspective. The occurrence of optimal non-normal transient growth around a stable fix point is shown to be highly improbable. Despite the possibility of encountering suboptimal non-normal transient growth, its magnitude is small and may not play an important role in the process of triggering a linearly stable thermoacoustic system to a nonlinear oscillating state. D...

    Abriebanalyse im Interfacegewebe aseptisch gelockerter Titanhüftendoprothesen und deren klinische Bedeutung

    In der vorliegenden klinisch-experimentellen Arbeit wurde Gewebe von 12 Patienten lichtmikroskopisch untersucht. Die Proben wurden im Rahmen von Hüftprothesenwechseloperationen gewonnen, die auf Grund einer aseptischen Lockerung nötig waren. In die Untersuchung wurden ausschließlich Patienten mit zementlosen oder zementierten Titanprothesen eingeschlossen. Die Gewebestücke wurden für die Lichtmikroskopie standardmäßig präpariert und mit einer HE-Färbung versehen. Ziel der Arbeit war die Ident...
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