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Name
MediaTUM
Type
Institutional Repository
Items
11165 Publications
Compatibility
OpenAIRE 2.0+ (DRIVER OA, EC funding)
OAI-PMH
http://mediatum.ub.tum.de/oai/oai
More information
Detailed data provider information (OpenDOAR)

 

  • Biopsychological interactions in autoimmune models of CNS inflammation

    In the present thesis, the interaction of inflammatory and biopsychological processes was investigated in a multidimensional approach. In an animal model of multiple sclerosis, the antiinflammatory properties of the antidepressant venlafaxine were demonstrated and the related mechanisms were dissected. To further characterize the impact of inflammatory processes on biopsychological functions an autoimmune model of cognitive impairment was established by active immunization with the neuronal a...

    Development of a behavioral test battery for the assessment of pharmacologic and non-pharmacologic environmental factors on the developing brain.

    Preterm infants are at a high risk of suffering from alterations in brain development with subsequent neurocognitive sequelae. Beside histochemical and biochemical methods, it is of utmost importance to evaluate the effect of environmental factors and interventions on functional outcome. In the present work a neurobehavioral test battery with several routines and procedures including testing, data processing and statistical analyses were successfully established, implement and tested on two...

    Characterization of metabolic-inflammatory features of the normal and the aneurysmatically altered aorta using FDG-PET/CT

    Abdominale Aortenaneurysmen (AAA) sind im Alter eine häufige Erkrankung und PET/CT wird derzeit als diagnostisches Mittel untersucht. Zur Charakterisierung des FDG-Uptakes der Aorta wurden je 19 Patienten mit und ohne AAA mittels PET/CT untersucht und das Uptake-Verhalten an anatomisch festgelegten Messpunkten durch eine Software partialvolumenkorrigiert und analysiert. Im Mittel ergab sich kein signifikanter Unterschied, einzelne Aortenabschnitte zeigten jedoch teils höhere und teils niedrig...

    Parallele und kombinatorische Methoden zur Synthese cyclischer Urokinaserezeptorantagonisten an fester Phase und in Lösung

    Die vorliegende Arbeit beschäftigt sich mit der parallelen und kombinatorischen Synthese von peptidischen und peptidomimetischen Antagonisten für den Urokinaserezeptor (uPAR, CD87) in Lösung und an fester Phase. Die Bindung des urokinaseartigen Plasminogen Aktivators (uPA) an den zugehörigen Rezeptor stellt einen der Schlüsselschritte für die Aktivierungskaskade der perizellulären Proteolyse dar. Eine Inhibierung der uPA/uPAR-Wechselwirkung führt entsprechend zu eingeschränktem Tumorwachstum ...

    Identifikation von neuen Regulatoren von systemisch erworbener Resistenz (SAR) in Pflanzen mit Hilfe eines auf Proteomics basierenden Ansatzes

    SAR plays a fundamental role in protecting plants against diseases. It is activated systemically following a primary infection. By comparing the protein profile of AvrRpm1-expressing Arabidopsis wild type against similar extracts from eds1-2 mutant plants we identified new potential SAR-inducing signals or signaling regulators. Proteomics (2D-gel, LC-MS/MS, ICPL) led to the detection of 21 proteins, which reproducibly accumulate in the apoplast of Col-0 plants in an EDS1-dependent manner. ...
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