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  • Abschiedsvorlesung von Prof. Dr. Paul Kirchhof

    Prof. Dr. Paul Kirchhof, langjähriger Direktor des Instituts für Finanz- und Steuerrecht an der Universität Heidelberg, hielt am 7. Juni 2013 seine Abschiedsvorlesung zum Thema "Forschen heißt hoffen". Als "Seniorprofessor distinctus" wird der Rechtswissenschaftler und ehemalige Bundesverfassungsrichter weiter an der Ruperto Carola wirken.

    Multi-component Reactions Initiated via Sonogashira Coupling

    It was shown that arylbromides bearing electron-withdrawing groups in appropriate positions can be subjected to Sonogashira coupling with terminal alkynes, producing internal alkynes that can now undergo a Michael addition with suitable secondary amines. This coupling-aminovinylation sequence can be performed in a one-pot fashion, providing a straightforward access to push-pull chromophores. By applying acid chlorides instead of arylbromides, it was possible to synthesize ynones that are hig...

    Genetic modification of oncolytic adenoviruses for anti-cancer-therapy

    Recombinant adenoviruses (Ad) have emerged as promising agents in therapeutic gene transfer, genetic vaccination and virotherapy. Virotherapy is defined as killing of cancer cells by specific virus infection, replication, cell lysis and virus spread by so called oncolytic viruses. “Armed” oncolytic Ad in which a therapeutic gene is genetically engineered into the virus and dependent on the tumour-selective replication of the virus for expression, represent a new and promising strategy for c...

    Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue.

    Tumor radiotherapy with charged particles offers superior properties in covering the tumor with radiation dose, while sparing the surrounding, healthy tissue better than standard X-rays. Thus, the success of the therapy is potentially increased. However, the application of this technique necessitates not only profound knowledge about its physical aspects, such as the uncertainties in the range of the particles which need to be taken into account in the therapy planning stage. In addition to t...
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