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241 Publications
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  • Функціональна диспепсія у світлі PимскИх критеріїв IV

    Tkach, S.M. (2016)
    The article deals with the problem of functional dyspepsia. The pathophysiology is described in detail, the diagnostic criteria of this disease are given, the aspects of treating patients with functional dyspepsia are considered. Drugs of first-line treatment in functional dyspepsia are prokinetics and proton pump inhibitors. The paper paid attention to a combined preparation containing domperidone (prokinetic) and omeprazole (proton pump inhibitor) — Omez DCR.

    Підвищення ефективності лікування хворих із перехресним синдромом функціональною диспепсією і неерозивною рефлюксною хворобою без наявності Нelicobacter рylori

    Djanelidze, D.T. (2013)
    In overlap syndrome functional dyspepsia and non-erosive reflux disease (FD/NERD) it is important to evaluate and correct the motor function of the stomach, anxiety-depressive and dyspeptic manifestations which affect the quality of life of the patient. The combination of a proton pump inhibitor with prokinetic and mebikar for the treatment of patients with FD/NERD without the presence of Helicobacter pylori showed the best results compared with other treatment regimens in different groups.

    Functional Dyspepsia and Irritable Bowel Syndrome: What Is Similar?

    Stepanov, Yu.M.; Budzak, I.Ya. (2016)
    The article presents the analysis of main functional diseases of digestive system — functional dyspepsia and irritable bowel syndrome. There was shown the similarity of pathogenic factors of these diseases. Besides traditional factors (motility disorders, visceral hypersensitivity), the special attention was paid to relatively new factors (gastrointestinal infection, minimal inflammation of mucosa, disorders of mucosa permeability etc). The attention was attracted to frequent over-lap of thes...

    Microstructural Changes in Hepatocytes against a Background of Liver Fibrosis in Patients with Chronic Diffuse Liver Diseases

    Stepanov, Yu.M.; Haidar, Yu.A.; Didenko, V.I.; Halenko, O.P.; Oshmyanska, N.Yu. (2016)
    Morphological analysis of the microstructural changes of hepatocytes has been performed in patients with chronic C viral hepatitis; the distribution of apoptosis markers and cytoskeletal proteins has been analyzed on the material of 41 liver biopsies. Using immunohistochemical analysis and computer morphometry there have been investigated microstructural changes which accompany the progression of fibrosis, particularly the mechanisms of hepatocytes apoptosis, localization of cytochrome C, mic...

    Діагностична значимість сироваткових маркерів фіброзу печінки у хворих на HCV-інфекцію

    Melanich, S.L. (2013)
    В работе рассмотрены диагностические возможности использования сывороточных маркеров фиброза печени у больных хронической HCV-инфекцией. Проведение специальных тестов (AAR, APRI, Forns’ score, FibroIndex, FIB-4, MDA, GUCI, SHASTA, k ЛН, k ММР-1 и k ЛН/ММР-1) с использованием прямых и непрямых маркеров фиброза печени является альтернативным неинвазивным, доступным методом диагностики фиброза печени....
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